Distribution and Heritability of Peripheral Eye Length in Chinese Children and Adolescents: The Guangzhou Twin Eye Study

Ding, Xiaohu; Wang, Decai; Huang, Qunxiao; Zhang, Jian; Chang, Jessica R.; He, Mingguang

doi:10.1167/iovs.12-10066

Cited by 13 publications

(11 citation statements)

References 34 publications

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“…Retinal shape can be estimated by indirect optical methods that are based on peripheral refraction [11][12][13], partial coherence interferometry [14][15][16][17][18][19][20][21][22][23][24] and optical coherence tomography [25,26]. However such methods rely on assumptions concerning shape and refractive index distribution through the lens and other structures within the eye, in order to convert optical path lengths into geometrical dimensions.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional MRI study of the relationship between eye dimensions, retinal shape and myopia

Pope

Verkicharla

Sepehrband

et al. 2017

Biomed. Opt. Express

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Abstract:We investigated changes in eye dimensions and retinal shape with degree of myopia, gender and race. There were 58 young adult emmetropes and myopes (range -1.25D to −8.25D), with 30 East-Asians (21 female/9 male), 23 Caucasians (16/7) and 5 SouthAsians (1/4). Three-dimensional magnetic resonance imaging was undertaken with a 3.0 Tesla whole-body clinical MRI system using a 4.0 cm receive-only surface coil positioned over the eye. Automated methods determined eye length, width and height, and curve fitting procedures determined asymmetric and symmetric ellipsoid shapes to 75%, 55% and 35% of the retina. With myopia increase, eye dimensions increased in all directions such that increase in length was considerably greater than increases in width and height. Emmetropic retinas were oblate (steepening away from the vertex) but oblateness decreased with the increase in myopia, so that retinas were approximately spherical at 7 to 8D myopia. Asymmetry of eyes about the best fit visual axis was generally small, with small differences between the vertex radii of curvature and between asphericities in the axial and sagittal planes. Females had smaller eyes than males, with overall dimensions being about 0.5mm less for the former. Race appeared not to have a systematic effect.

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Section: Introductionmentioning

confidence: 99%

Three-dimensional MRI study of the relationship between eye dimensions, retinal shape and myopia

Pope

Verkicharla

Sepehrband

et al. 2017

Biomed. Opt. Express

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“…To estimate the relationship between retinal shape and myopia, retinal shape has been inferred from peripheral refraction and peripheral eye length measurements . For example, positive relative peripheral refraction and negative relative peripheral eye length are considered to be associated with a ‘prolate’ shape (flattening away from the vertex) of the retina.…”

Section: Introductionmentioning

confidence: 99%

Differences in retinal shape between East Asian and Caucasian eyes

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Suheimat

Schmid

et al. 2017

Ophthalmic Physiologic Optic

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“…Traditionally, a genetic factor has been emphasized because of the observation that myopic parents give birth to myopic children. In fact, heritability was confirmed statistically in multiple studies with monozygotic and heterozygotic twins . Studies of 12‐year‐old Australian children showed that prevalence of myopia increases with the number of myopic parents.…”

Section: Genetics Of Myopiamentioning

confidence: 82%

Concise Review: Using Stem Cells to Prevent the Progression of Myopia—A Concept

et al. 2015

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The prevalence of myopia has increased in modern society due to the educational load of children. This condition is growing rapidly, especially in Asian countries where it has already reached a pandemic level. Typically, the younger the child’s age at the onset of myopia, the more rapidly the condition will progress and the greater the likelihood that it will develop the known sight-threatening complications of high myopia. This rise in incidence of severe myopia has contributed to an increased frequency of eye diseases in adulthood, which often complicate therapeutic procedures. Currently, no treatment is available to prevent myopia progression. Stem cell therapy can potentially address two components of myopia. Regardless of the exact etiology, myopia is always associated with scleral weakness. In this context, a strategy aimed at scleral reinforcement by transplanting connective tissue-supportive mesenchymal stem cells (MSCs) is an attractive approach that could yield effective and universal therapy. Sunlight exposure appears to have a protective effect against myopia. It is postulated that this effect is mediated via local ocular production of dopamine. With a variety of dopamine-producing cells already available for the treatment of Parkinson’s disease, stem cells engineered for dopamine production could be utilized for the treatment of myopia. In this review, we further explore these concepts and present evidence from the literature to support the use of stem cell therapy for the treatment of myopia.

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Distribution and Heritability of Peripheral Eye Length in Chinese Children and Adolescents: The Guangzhou Twin Eye Study

Abstract: Additive genetic effects had a substantial influence on phenotypic variation in PEL and RPEL, suggesting genetic rather than environmental factors play a major role in determining eye shape.

Cited by 13 publications

References 34 publications

Three-dimensional MRI study of the relationship between eye dimensions, retinal shape and myopia

Three-dimensional MRI study of the relationship between eye dimensions, retinal shape and myopia

Differences in retinal shape between East Asian and Caucasian eyes

Concise Review: Using Stem Cells to Prevent the Progression of Myopia—A Concept

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