Distribution and excretion of 614C9polychlorinated biphenyls after their prolonged administration to male rats

Hashimoto, Katsufumi; Akasaka, Susumu; Takagi, Yasuhiro; Kataoka, Masayuki; Otake, T.

doi:10.1016/0041-008x(76)90203-9

Cited by 12 publications

(3 citation statements)

References 11 publications

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“…There are several reports of animal experiments with high level exposure to PCBs (Grant et al 1971, Hashimoto et al 1976, Hayes et al 1971), but only a few report any low-level exposure data. Price et al (1972) reported pesticide residues and PCB levels in diets, urine, and fecal matter of preadolescent girls.…”

Section: Excretion Of Pcbsmentioning

confidence: 95%

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Long-term studies of the excretion of polychlorinated biphenyls (PCBs) through the mother's milk of an occupationally exposed worker

Yakushiji

Watanabe

Kuwabara

et al. 1978

Arch. Environ. Contam. Toxicol.

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Abstract.Long-term studies of the excretion of polychlorinated biphenyls (PCBs) through the mother's milk were conducted on an occupationally exposed worker, who worked with PCBs in a capacitor factory.PCBs level in the mother's blood was 57 ppb, a level 10 to 20 times higher than that of non-exposed persons. The other tissues and fluids obtained at time of delivery were also assayed. PCB contents in umbilicus tissues, umbilicus blood and amnion fluid were l/s, 1/4 and 1/8, respectively, the amount found in the mother's blood.An approximate 76% decrease in PCB levels in the milk were noted 16 months after delivery; 200 mg of PCBs were excreted in about 818 liters of milk for this 16-month period.A detailed analysis of the individual components in PCB residues clarified the remarkable changes of the PCB pattern in the blood.Since PCBs in mother's milk were detected in the high concentration range of 0.01 to 0.7 ppm on the whole milk basis in Japan in 1972 (Isono 1972), many research institutes have been investigating the environmental behavior of PCBs. Therefore, the residue levels to be expected and related new information became available from these studies (Takeshita et al. 1974, Hashimoto et al. 1976, Shimada 1976, Nakayama and Aoki 1977, Nishimura et al. 1977).In our investigation of PCBs in blood and mother's milk of non-exposed women for 6 years, we have been studying the problem of breast-feeding through the su-vey of PCBs. The levels of PCB in mother's milk and blood were almost stable from 1972 to 1977; in the range os 0.03 to 0.04 ppm on the whole milk basis (Yakushiji et al. 1977a, b). An average intake of 150 ml/kg of milk per day per baby would mean that each baby would consume approximately 4.5 to 6/zg/kg of PCB's per day. Then one-half the number of Japanese babies would ingest larger

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Section: Excretion Of Pcbsmentioning

confidence: 95%

“…Therefore, the residue levels to be expected and related new information became available from these studies (Takeshita et al 1974, Hashimoto et al 1976, Shimada 1976, Nakayama and Aoki 1977, Nishimura et al 1977). …”

Section: Introductionmentioning

confidence: 97%

Long-term studies of the excretion of polychlorinated biphenyls (PCBs) through the mother's milk of an occupationally exposed worker

Yakushiji

Watanabe

Kuwabara

et al. 1978

Arch. Environ. Contam. Toxicol.

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“…The tissue distribution of PBBs in maternal animals followed a pattern similar to that of polychlorinated biphenyls (PCBs) (9,10). Levels of PBBs were highest in those tissues with the highest lipid content such as mammary tissue and adipose tissue.…”

Section: Discussionmentioning

confidence: 79%

Distribution of polybrominated biphenyls after dietary exposure in pregnant and lactating rats and their offspring.

Rickert¹,

Dent²,

Cagen³

et al. 1978

Environ Health Perspect

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Female rats were fed PBBs in the diet (50 ppm) from day 8 of gestation to day 21 of gestation, from day 1 postpartum to day 14 postpartum or from day 8 of gestation through day 14 postpartum. Levels of PBBs were measured in various tissues. Small concentrations of PBBs (<5 ,g/g) were found in the brain, heart, lung, liver, small intestine, placenta, and gravid uterus. Larger concentrations (<30 ,tg/g) were found in kidneys, the nongravid uterus, skin, mammary tissue, and fat. Lactation did not significantly alter the concentrations of PBBs found in tissues other than mammary tissue.Offspring were subjected to several exposure regimens by cross-fostering. Concentrations of PBBs in the neonatal livers were higher than in the adults nursing them. Transfer of PBBs via the milk appears to be much more important to appearance of PBBs in newborns than does placental transfer.

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Transfer and distribution of accumulated (14C)polychlorinated biphenyls from maternal to fetal and suckling rats

Takagi

Aburada

Hashimoto

et al. 1986

Arch. Environ. Contam. Toxicol.

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Distribution and excretion of 614C9polychlorinated biphenyls after their prolonged administration to male rats

Cited by 12 publications

References 11 publications

Long-term studies of the excretion of polychlorinated biphenyls (PCBs) through the mother's milk of an occupationally exposed worker

Long-term studies of the excretion of polychlorinated biphenyls (PCBs) through the mother's milk of an occupationally exposed worker

Distribution of polybrominated biphenyls after dietary exposure in pregnant and lactating rats and their offspring.

Transfer and distribution of accumulated (14C)polychlorinated biphenyls from maternal to fetal and suckling rats

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