Distribution and characterization of Corazonin in the central nervous system of Triatoma infestans (Insecta: Heteroptera)

Settembrini, Beatriz P.; Pasquale, Daniela De; Postal, Melissa; Pinto, Paulo Marcos; Carlini, Célia R.; Villar, Marcelo J.

doi:10.1016/j.peptides.2010.10.020

Cited by 12 publications

(5 citation statements)

References 44 publications

(49 reference statements)

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“…We observed immunoreactivity within the brain and ventral ganglion, it was very weak and mostly confined to a few neuronal somata in the brain and neurites in the ventral ganglion, indicating that the antiserum only weakly recognizes [Met 2 , Arg 10 ]-corazonin. We nevertheless observed distinct corazonin-immunoreactive staining of densely arborising neurite endings in the retrocerebral–aorta complex (Figure E), similar to the situation in other Heteroptera. ,, We also observed ion signals of corazonin in MALDI TOF mass spectra from preparations of the retrocerebral complex (Figure A) and Orbitrap MSMS spectra from CNS extract (Figure B), which confirmed that the unusual C. lectularius corazonin is released as a hormone.…”

Section: Results and Discussionsupporting

confidence: 84%

“…We nevertheless observed distinct corazonin-immunoreactive staining of densely arborising neurite endings in the retrocerebral− aorta complex (Figure 1E), similar to the situation in other Heteroptera. 39,58,59 We also observed ion signals of corazonin in MALDI TOF mass spectra from preparations of the retrocerebral complex (Figure 3A) and Orbitrap MSMS spectra from CNS extract (Figure 4B), which confirmed that the unusual C. lectularius corazonin is released as a hormone.…”

Section: Identification Of Neuropeptides In the Central Nervous Syste...supporting

confidence: 61%

“…This is remarkable, as the C-terminal part is usually considered to be important for receptor binding and activation. In R. prolixus, 39 T. infestans, 58 the linden bug Pyrrhocoris apterus, 59 and indeed most other insects, corazonin is expressed in secretory neurons of the pars lateralis of the protocerebrum. These neurons release the peptide as a hormone at the neurohemal retrocerebral-aorta complex.…”

Section: Identification Of Neuropeptides In the Central Nervous Syste...mentioning

confidence: 99%

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Neuropeptidomics of the Bed BugCimex lectularius

et al. 2017

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The bed bug Cimex lectularius is a globally distributed human ectoparasite with fascinating biology. It has recently acquired resistance against a broad range of insecticides, causing a worldwide increase in bed bug infestations. The recent annotation of the bed bug genome revealed a full complement of neuropeptide and neuropeptide receptor genes in this species. With regard to the biology of C. lectularius, neuropeptide signaling is especially interesting because it regulates feeding, diuresis, digestion, as well as reproduction and also provides potential new targets for chemical control. To identify which neuropeptides are translated from the genome-predicted genes, we performed a comprehensive peptidomic analysis of the central nervous system of the bed bug. We identified in total 144 different peptides from 29 precursors, of which at least 67 likely present bioactive mature neuropeptides. C. lectularius corazonin and myosuppressin are unique and deviate considerably from the canonical insect consensus sequences. Several identified neuropeptides likely act as hormones, as evidenced by the occurrence of respective mass signals and immunoreactivity in neurohemal structures. Our data provide the most comprehensive peptidome of a Heteropteran species so far and in comparison suggest that a hematophageous life style does not require qualitative adaptations of the insect peptidome.

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Section: Results and Discussionsupporting

confidence: 84%

Section: Identification Of Neuropeptides In the Central Nervous Syste...supporting

confidence: 61%

Section: Identification Of Neuropeptides In the Central Nervous Syste...mentioning

confidence: 99%

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Neuropeptidomics of the Bed BugCimex lectularius

et al. 2017

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“…infestans, a blood feeding heteropteran, is the main vector of Chagas' disease in Argentina and neighboring countries. Morphological, biochemical and molecular biology approaches have been employed to study the CNS of this triatomine [30,31], making this species a suitable model for the investigation of neurotoxicity of entomotoxic molecules [29]. In this study, we investigated the effect of Jbtx in the CNS of T. infestans.…”

Section: Introductionmentioning

confidence: 99%

Effect of the urease-derived peptide Jaburetox on the central nervous system of Triatoma infestans (Insecta: Heteroptera)

Galvani

Fruttero

Coronel

et al. 2015

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…The spatial distribution of Crz is largely conserved in insect brains (e.g., Predel et al, 2007; Roller et al, 2003; Settembrini et al, 2011; Veenstra & Davis, 1993; Wen & Lee, 2008). Corazonergic cell bodies are often located in the region of the pars lateralis and exhibit projections to the SMP and the RCC.…”

Section: Discussionmentioning

confidence: 99%

Neuropeptides as potential modulators of behavioral transitions in the ant Cataglyphis nodus

Habenstein

Thamm

Rößler

2021

J of Comparative Neurology

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Age‐related behavioral plasticity is a major prerequisite for the ecological success of insect societies. Although ecological aspects of behavioral flexibility have been targeted in many studies, the underlying intrinsic mechanisms controlling the diverse changes in behavior along the individual life history of social insects are not completely understood. Recently, the neuropeptides allatostatin‐A, corazonin, and tachykinin have been associated with the regulation of behavioral transitions in social insects. Here, we investigated changes in brain localization and expression of these neuropeptides following major behavioral transitions in Cataglyphis nodus ants. Our immunohistochemical analyses in the brain revealed that the overall branching pattern of neurons immunoreactive (ir) for the three neuropeptides is largely independent of the behavioral stages. Numerous allatostatin‐A‐ and tachykinin‐ir neurons innervate primary sensory neuropils and high‐order integration centers of the brain. In contrast, the number of corazonergic neurons is restricted to only four neurons per brain hemisphere with cell bodies located in the pars lateralis and axons extending to the medial protocerebrum and the retrocerebral complex. Most interestingly, the cell‐body volumes of these neurons are significantly increased in foragers compared to freshly eclosed ants and interior workers. Quantification of mRNA expression levels revealed a stage‐related change in the expression of allatostatin‐A and corazonin mRNA in the brain. Given the presence of the neuropeptides in major control centers of the brain and the neurohemal organs, these mRNA‐changes strongly suggest an important modulatory role of both neuropeptides in the behavioral maturation of Cataglyphis ants.

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Distribution and characterization of Corazonin in the central nervous system of Triatoma infestans (Insecta: Heteroptera)

Cited by 12 publications

References 44 publications

Neuropeptidomics of the Bed BugCimex lectularius

Neuropeptidomics of the Bed BugCimex lectularius

Effect of the urease-derived peptide Jaburetox on the central nervous system of Triatoma infestans (Insecta: Heteroptera)

Neuropeptides as potential modulators of behavioral transitions in the ant Cataglyphis nodus

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