Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer

Abstract

Objectives: xMany Africans were brought to Brazil as slaves. The runaway or abandoned slaves founded isolated communities named quilombos. There are many quilombo remnants in Vale do Ribeira region in the southern part of São Paulo State. The aim of our study was to contribute to understanding the origins of these populations, through admixture studies. Methods: We genotyped 307 unrelated DNA samples obtained from ten quilombo populations from Vale do Ribeira region, using a panel of 48 INDEL polymorphisms. We estimated genetic differentiation between populations (FST) and genomic ancestry from these populations. Our data were compared to a similar study performed in quilombo remnants from the Brazilian Amazon region. Results: Population admixture estimates showed high degree of miscegenation in the quilombo remnants from Vale do Ribeira (average admixture estimates at 39.7% of African, 39.0% of European and 21.3% of Amerindian contribution). The proportions of ancestral genes varied greatly among individuals, ranging from 7.3 to 69.5%, 12.9 to 68.3%, and 7.3 to 58.5% (African, European, and Amerindian, respectively). Genetic differentiation between these populations was low (all FST values <5%), indicating gene flow between them. Both groups of quilombos, from Vale do Ribeira and Amazon, presented similar patterns of admixture. Conclusions: INDEL markers were useful to evidence the triple interbreeding among African, European, and Amerindian in the formation of quilombo populations. The low FST values suggested gene flow among quilombos from Vale do Ribeira. Our data highlight the important role of Amerindians in the formation of quilombo populations. Am. J. Hum. Biol., 2013. © 2012 Wiley Periodicals, Inc.

Does rapid genetic counseling and testing in newly diagnosed breast cancer patients cause additional psychosocial distress? results from a randomized clinical trial

“…Such heightened levels of distress and compromised HRQL have also been described in breast cancer patients without a high-risk profile. [16][17][18] Unfortunately, we did not have data available for breast cancer patients without a high-risk profile for comparison of distress levels. Contrary to our original expectations, at follow-up, women in the RGCT group did not report significantly lower levels of cancer worries or cancer-related distress or more problems with body image or sexuality than the UC group.…”

Interaction of Coping Styles and Psychological Stress on Anxious and Depressive Symptoms in Chinese Breast Cancer Patients

“…The later may develop several psychological symptoms such as depression, anxiety, other form of psychological morbidity (Reynolds et al, 2000;Landmark et al, 2001;Coward et al, 2004). Studies indicate that 20% to 40% of women with breast cancer show a significant level of distress (GoldenKreutz and Andersen, 2004;Bardwell et al, 2006;Hegel et al, 2006). There are interpersonal differences in the degree of psychological distress, which factors may include demographic characteristics such as financial problems, educational level, and marital status, as well as personal psychiatric history and level of social support (Ando et al, 2011).…”

Sensitivity and specificity of the Distress Thermometer for depression in newly diagnosed breast cancer patients

“…can be extreme and persistent, often presaging a psychiatric disorder, such as major depression [1].…”