Distraction Modulates Anterior Cingulate Gyrus Activations during the Cold Pressor Test

Frankenstein, Uta; Richter, Wolfgang; McIntyre, Margaret; Rémy, François

doi:10.1006/nimg.2001.0883

Cited by 183 publications

(107 citation statements)

References 35 publications

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“…PET and fMRI studies have demonstrated modulation of blood flow or BOLD in SI and secondary somatosensory cortex (SII), anterior cingulate cortex (ACC), orbitofrontal cortex, and insula by attention to painful stimuli (Bantick et al 2002;Brooks et al 2002;Davis et al 1997;Frankenstein et al 2001;Hofbauer et al 2001;Petrovic et al 2000). These findings may be consistent with the significant ERS at central and midline channels during the count laser task (Table 3).…”

Section: Discussionmentioning

confidence: 54%

Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli

Chien

Liu

Kim

et al. 2014

Journal of Neurophysiology

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Chien JH, Liu CC, Kim JH, Markman TM, Lenz FA. Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli. J Neurophysiol 112: 824 -833, 2014. First published May 21, 2014 doi:10.1152/jn.00209.2014.-The non-phase-locked EEG response to painful stimuli has usually been characterized as decreased oscillatory activity (event-related desynchronization, ERD) in the alpha band. Increased activity (event-related synchronization, ERS) in the gamma band has been reported more recently. We have now tested the hypothesis that the non-phase-locked responses to nonpainful electric cutaneous stimuli are different from those to painful cutaneous laser stimuli when the baseline salience of the two stimuli is the same and the salience during the protocol is modulated by count laser and count electric tasks. Both of these stimuli were presented in random order in a single train at intensities that produced the same baseline salience in the same somatic location. The response to the laser stimulus was characterized by five windows (designated windows I-V) in the time-frequency domain: early (200 -400 ms) and late (600 -1,400 ms) delta/theta ERS, 500 -900 ms alpha ERD, 1,200 -1,600 ms beta ERS (rebound), and 800 -1,200 ms gamma ERS. Similar ERS/ERD windows of activity were found for the electric stimulus. Individual participants very commonly had activity in windows consistent with the overall analysis. Linear regression of ERS/ERD for parietal channels was most commonly found for sensory (pain or unpleasantness)-or attention (salience)-related measures. Overall, the main effect for modality was found in window I-delta/theta and window V-gamma, and the Modality with Task interaction was found in all five windows. All significant interaction terms included Modality as a factor. Therefore, Modality was the most common factor explaining our results, which is consistent with our hypothesis. attention; cortex; event-related synchronization; EEG; human; pain EVENT-RELATED CHANGES in EEG spectral power can be measured by a decrease in oscillatory activity (event-related desynchronization, ERD) or an increase in oscillatory activity (event-related synchronization, ERS) (Lopes da Silva and Pfurtscheller 1999). These spectral responses (ERS/ERD) are not phase locked to the event but are analyzed by signal averaging in the frequency domain. Different frequency bands exhibit different temporal, spatial, and task-related characteristics, which are consistent with their involvement in different aspects of cerebral processing (Bastiaansen and Brunia 2001;Boiten et al. 1992;Klimesch et al. 1998;Tiihonen et al. 1991). Event-related spectral modulation of scalp EEG has also been applied to studies of the cortical processing of painful stimuli.In response to painful stimuli, ERD has been found most frequently in the alpha band (Babiloni et al. 2006;Ferracuti et al. 1994;Hu et al. 2013;Mouraux et al. 2003;Ploner et al. 2006). ERS has also been reported at long...

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Section: Discussionmentioning

confidence: 54%

Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli

Chien

Liu

Kim

et al. 2014

Journal of Neurophysiology

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“…A number of imaging studies that utilize distracting tasks show modulation of painevoked activity in thalamus and in several cortical regions, including S1, ACC, and IC (13,(27)(28)(29)(30)(31). Other regions, including PAG, parts of ACC, and orbitofrontal cortex (within the PFC) have been shown to be activated when subjects perform distracting tasks, thus suggesting that these regions may be involved in the modulatory circuitry related to attention (30,(32)(33)(34). Nevertheless, most of the distracting tasks require increased cognitive demand, and The color-coded regions superimposed on an anatomical MRI (coronal slice).…”

Section: Mechanisms Underlying Psychological Modulation Of Painmentioning

confidence: 99%

Pain imaging in health and disease — how far have we come?

Schweinhardt

Bushnell²

2010

J. Clin. Invest.

191

145

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Since modern brain imaging of pain began 20 years ago, networks in the brain related to pain processing and those related to different types of pain modulation, including placebo, have been identified. Functional and anatomical connectivity of these circuits has begun to be analyzed. Imaging in patients suggests that chronic pain is associated with altered function and structural abnormalities in pain modulatory circuits. Moreover, biochemical alterations associated with chronic pain are being identified that provide information on cellular correlates as well as potential mechanisms of structural changes. Data from these brain imaging studies reinforce the idea that chronic pain leads to brain changes that could have functional significance.

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“…Brain-specific mechanisms of experimentally induced acute pain have already been described in several studies, inter alia with the assistance of functional magnetic resonance imaging (fMRI), neuroelectrophysiological and neurosurgical procedures [1][2][3][4][5][6][7][8]. Structures involved in processing the multidimensional aspect of pain perception are often summarised with the term "pain matrix", and include several regions consistently found within investigations [1,8,9], hence accommodating the complex neurosignature pattern of pain [10].…”

Section: Insula-specific Responses Induced By Dental Pain a Proton Mmentioning

confidence: 99%

Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study

Gutzeit

Meier

et al. 2010

Eur Radiol

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Insula-specific responses induced by dental pain: a proton magnetic resonance spectroscopy study Abstract OBJECTIVES: To evaluate whether induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex after stimulation of the right maxillary canine and to examine whether these metabolic changes and the subjective pain intensity perception correlate. METHODS: Ten male volunteers were included in the pain group and compared with a control group of 10 other healthy volunteers. The pain group received a total of 87-92 electrically induced pain stimuli over 15 min to the right maxillary canine tooth. Contemporaneously, they evaluated the subjective pain intensity of every stimulus using an analogue scale. Neurotransmitter changes within the left insular cortex were evaluated by MR spectroscopy. RESULTS: Significant metabolic changes in glutamine (+55.1%), glutamine/glutamate (+16.4%) and myo-inositol (-9.7%) were documented during pain stimulation. Furthermore, there was a significant negative correlation between the subjective pain intensity perception and the metabolic levels of Glx, Gln, glutamate and N-acetyl aspartate. CONCLUSION: The insular cortex is a metabolically active region in the processing of acute dental pain. Induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex resulting in significant alterations in metabolites. Negative correlation between subjective pain intensity rating and specific metabolites could be observed. Objectives: To evaluate whether induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex after stimulation of the right maxillary canine, and further to examine whether these metabolic changes and the subjectively rated pain intensity perception correlate.Methods: This prospective clinical study was performed with approval of the institutional review board and informed consent was given by all volunteers.Ten male volunteers were included in the pain group and compared with a control group of 10 other healthy volunteers. The pain group received a total of 87-92 electrically induced pain stimuli over 15 min to the right maxillary canine tooth. Contemporaneously, they evaluated the subjective pain intensity of every stimulus using an analogue scale.Neurotransmitter changes within the left insular cortex were evaluated by means of MR spectroscopy before, during and after pain stimulation.Results: Significant metabolic changes in glutamine (+55.1%), glutamine/glutamate (+16.4%) and myo-inositol (-9.7%) were documented during pain stimulation in comparison to baseline values. Furthermore, there was a significant negative correlation between the subjective pain intensity perception and the metabolic levels of Glx, Gln, glutamate and N-acetyl aspartate.Conclusion: The insular cortex is a metabolically active region in the processing of acute dental pain. Induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex resulting ...

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Distraction Modulates Anterior Cingulate Gyrus Activations during the Cold Pressor Test

Cited by 183 publications

References 35 publications

Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli

Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli

Pain imaging in health and disease — how far have we come?

Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study

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