Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli

Abstract

Chien JH, Liu CC, Kim JH, Markman TM, Lenz FA. Painful cutaneous laser stimuli induce event-related oscillatory EEG activities that are different from those induced by nonpainful electrical stimuli. J Neurophysiol 112: 824 -833, 2014. First published May 21, 2014 doi:10.1152/jn.00209.2014.-The non-phase-locked EEG response to painful stimuli has usually been characterized as decreased oscillatory activity (event-related desynchronization, ERD) in the alpha band. Increased activity (event-related synchronization, ERS) in the gamma band has been reported more recently. We have now tested the hypothesis that the non-phase-locked responses to nonpainful electric cutaneous stimuli are different from those to painful cutaneous laser stimuli when the baseline salience of the two stimuli is the same and the salience during the protocol is modulated by count laser and count electric tasks. Both of these stimuli were presented in random order in a single train at intensities that produced the same baseline salience in the same somatic location. The response to the laser stimulus was characterized by five windows (designated windows I-V) in the time-frequency domain: early (200 -400 ms) and late (600 -1,400 ms) delta/theta ERS, 500 -900 ms alpha ERD, 1,200 -1,600 ms beta ERS (rebound), and 800 -1,200 ms gamma ERS. Similar ERS/ERD windows of activity were found for the electric stimulus. Individual participants very commonly had activity in windows consistent with the overall analysis. Linear regression of ERS/ERD for parietal channels was most commonly found for sensory (pain or unpleasantness)-or attention (salience)-related measures. Overall, the main effect for modality was found in window I-delta/theta and window V-gamma, and the Modality with Task interaction was found in all five windows. All significant interaction terms included Modality as a factor. Therefore, Modality was the most common factor explaining our results, which is consistent with our hypothesis. attention; cortex; event-related synchronization; EEG; human; pain EVENT-RELATED CHANGES in EEG spectral power can be measured by a decrease in oscillatory activity (event-related desynchronization, ERD) or an increase in oscillatory activity (event-related synchronization, ERS) (Lopes da Silva and Pfurtscheller 1999). These spectral responses (ERS/ERD) are not phase locked to the event but are analyzed by signal averaging in the frequency domain. Different frequency bands exhibit different temporal, spatial, and task-related characteristics, which are consistent with their involvement in different aspects of cerebral processing (Bastiaansen and Brunia 2001;Boiten et al. 1992;Klimesch et al. 1998;Tiihonen et al. 1991). Event-related spectral modulation of scalp EEG has also been applied to studies of the cortical processing of painful stimuli.In response to painful stimuli, ERD has been found most frequently in the alpha band (Babiloni et al. 2006;Ferracuti et al. 1994;Hu et al. 2013;Mouraux et al. 2003;Ploner et al. 2006). ERS has also been reported at long...

A novel approach to identify time-frequency oscillatory features in electrocortical signals

“…4). In line with previous studies (Chien et al, 2014;GarciaLarrea et al, 1997;Iannetti et al, 2008;Schulz et al, 2011), both features are the time-frequency representations of the typical phase-locked vertex potentials. The vertex potentials can be elicited by stimuli of various sensory modalities (e.g., auditory, visual, and somatosensory) (Baseler et al, 1994;Goff et al, 1977), and regardless of the sensory modality of the applied stimuli, the vertex potentials captured similar shape, scalp topography, and sensitivity to experimental manipulations .…”

Vigilance behaviors and EEG activity in sustained attention may affect acute pain

“…These plots also show an Alpha ERD which decreased in the Second Interval (Window III, Figure 1) followed by a Beta rebound ERS which increased in the Second Interval (Window IV). The time frequency Windows I to IV (Table 1) for the oscillatory activities following the laser are shown in Figure 1A and are similar to those reported in previous studies of activity induced by the laser stimulus [7,26,27].…”

“…The spectral estimates in the trial and time dimensions were randomly resampled one thousand times during the baseline period of 0 to 0.5 s prestimulus [7,24]. The baseline in this approach includes approximately equal numbers cases in which a laser or an electrical stimulus precedes any trial so that the preceding trial does not bias the results.…”

“…ERD and ERS occur in different frequencies following painful laser stimuli and in Alpha and Beta Windows during attention to painful stimuli [7][8][9].…”

Oscillatory EEG activity induced by conditioning stimuli during fear conditioning reflects Salience and Valence of these stimuli more than Expectancy

“…Conditioning was measured by (i) the CS Expectancy, which was the likelihood that either CS is paired with the US from 0 for very unlikely to 10 for very likely, and (ii) the CS+ Valence which was the unpleasantness of the CS+. Salience of a stimulus (CSs and US) was described as ‘the ability of the stimulus to capture, attention’ (Mouraux and Iannetti, 2009) (see also (Zaslansky et al, 1995; Downar et al, 2002, 2003; Lorenz and Garcia-Larrea, 2003; Legrain et al, 2005; Chien et al, 2014) and was rated on a numerical rating scale for which 0 was the absence of Salience and 10 was the most salient stimulus imaginable.…”