Distracted mandible does not reach the same strength as normal mandible in rabbits

Bulut, Türker; Durmuş, Ercan; Mihmanlı, Ahmet; Dolanmaz, Doğan; Kalaycı, Abdullah; Sağlam, Hacı

doi:10.1016/j.oooo.2011.09.024

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…The Ti fiber scaffolds provide elasticity to the bone-scaffold complex by integrating with the newly formed bone, creating a high resistance to bending force. In this study, the mean loading force required to break the bone-HA-coated scaffold connection was around 200 N. It has been reported that a strength value in a 3-point bending test was 422 N in normal rabbit mandibular bone and approximately 200-250 N in distracted mandibular bone [28,29].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 53%

Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold

et al. 2016

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 53%

Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold

et al. 2016

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“…All hemi-mandibles were tested to failure in a 3-point flexure mode at a constant strain rate of 1 mm/min while supported across a 30 mm span on a universal testing machine (Lloyd LRX; Lloyd Instruments, West Sussex, UK). The lingual side of the mandible was facing down and a 5-mm thick foam rubber was placed between each sample and the loading supports to evenly distribute the load using methods previously reported for rabbit mandible flexural testing3334. The flexural modulus and strength were calculated from the test data collected (n=8 samples/group, n=7 samples for the 15 mm×10 mm defect size).…”

Section: Methodsmentioning

confidence: 99%

Are critical size bone notch defects possible in the rabbit mandible?

Carlisle¹,

Guda

Silliman³

et al. 2019

J Korean Assoc Oral Maxillofac Surg

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Objectives Small animal maxillofacial models, such as non-segmental critical size defects (CSDs) in the rabbit mandible, need to be standardized for use as preclinical models of bone regeneration to mimic clinical conditions such as maxillofacial trauma. The objective of this study is the establishment of a mechanically competent CSD model in the rabbit mandible to allow standardized evaluation of bone regeneration therapies. Materials and Methods Three sizes of bony defect were generated in the mandibular body of rabbit hemi-mandibles: 12 mm×5 mm, 12 mm×8 mm, and 15 mm×10 mm. The hemi-mandibles were tested to failure in 3-point flexure. The 12 mm×5 mm defect was then chosen for the defect size created in the mandibles of 26 rabbits with or without cautery of the defect margins and bone regeneration was assessed after 6 and 12 weeks. Regenerated bone density and volume were evaluated using radiography, micro-computed tomography, and histology. Results Flexural strength of the 12 mm×5 mm defect was similar to its contralateral; whereas the 12 mm×8 mm and 15 mm×10 mm groups carried significantly less load than their respective contralaterals ( P <0.05). This demonstrated that the 12 mm×5 mm defect did not significantly compromise mandibular mechanical integrity. Significantly less ( P <0.05) bone was regenerated at 6 weeks in cauterized defect margins compared to controls without cautery. After 12 weeks, the bone volume of the group with cautery increased to that of the control without cautery after 6 weeks. Conclusion An empty defect size of 12 mm×5 mm in the rabbit mandibular model maintains sufficient mechanical stability to not require additional stabilization. However, this defect size allows for bone regeneration across the defect. Cautery of the defect only delays regeneration by 6 weeks suggesting that the performance of bone graft materials in mandibular defects of this size should be considered with caution.

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“…18 Mandibles were placed with the lingual section facing upward and loaded under displacement control at a rate of 0.5 mm/s until fracture occurred. A customdesigned jig using the MTS mini-bionix 858 (MTS, Eden Prairie, MN) was developed ensuring that the hemimandible would only move or experience stress when the device was activated.…”

Section: Postoperative Monitoring and Analysismentioning

confidence: 99%

Comparison of Free Fibular Flaps With Reamer-Irrigator-Aspirator Bone Grafts for the Reconstruction of Critical-Sized Mandibular Defects

Dorafshar¹,

Mundinger²,

Mohan³

et al. 2014

Journal of Craniofacial Surgery

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Distracted mandible does not reach the same strength as normal mandible in rabbits

Cited by 6 publications

References 23 publications

Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold

Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold

Are critical size bone notch defects possible in the rabbit mandible?

Comparison of Free Fibular Flaps With Reamer-Irrigator-Aspirator Bone Grafts for the Reconstruction of Critical-Sized Mandibular Defects

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