Distorted Multisensory Experiences of Order and Simultaneity

Vatakis, Argiro; Bakou, Alexandra Elissavet

doi:10.1163/9789004230699_002

Cited by 3 publications

(2 citation statements)

References 134 publications

(166 reference statements)

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“…These results indicate that decreases in dopaminergic function do not affect the ability to discriminate the relative location of two stimuli, whether these stimuli are separated in time or in space. Studies in patients with schizophrenia have previously revealed impairments in temporal order processing, which raises the possibility that dopamine could play a role in this process ( Vatakis & Bakou, 2015;Capa et al, 2014;Schwartz et al, 1991). However, the lack of effect of APTD on the TOJ task suggests that previously reported temporal order deficits in patients might be related to nondopaminergic aspects of the pathology.…”

Section: Aptd Does Not Impair Temporal Order Processingmentioning

confidence: 96%

“…Although many studies demonstrate an important role for dopamine in duration processing, very few have investigated other facets of timing such as the processing of temporal order or simultaneity. Yet patients with schizophrenia have difficulty processing not only the duration but also the temporal order of events ( Vatakis & Bakou, 2015;Capa, Duval, Blaison, & Giersch, 2014;Schwartz, Deutsch, Cohen, Warden, & Deutsch, 1991). Moreover, Bellgrove et al (2006) found that A2 allele TAq1 polymorphisms of the gene encoding dopamine beta hydroxylase (which catalyses the transformation of dopamine into noradrenaline) in ADHD is associated with deficits in temporal order judgments (TOJs).…”

Section: Introductionmentioning

confidence: 99%

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Dopamine Precursor Depletion in Healthy Volunteers Impairs Processing of Duration but Not Temporal Order

Chassignolle

Jovanović

Schmidt-Mutter

et al. 2021

Journal of Cognitive Neuroscience

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Studies in animals and humans have implicated the neurotransmitter dopamine in duration processing. However, very few studies have examined dopamine's involvement in other forms of temporal processing such as temporal order judgments. In a randomized within-subject placebo-controlled design, we used acute phenylalanine/tyrosine depletion (APTD) to reduce availability of the dopamine precursors tyrosine and phenylalanine in healthy human volunteers. As compared to a nutritionally balanced drink, APTD significantly impaired the ability to accurately reproduce interval duration in a temporal reproduction task. In addition, and confirming previous findings, the direction of error differed as a function of individual differences in underlying dopamine function. Specifically, APTD caused participants with low baseline dopamine precursor availability to overestimate the elapse of time, whereas those with high dopamine availability underestimated time. In contrast to these effects on duration processing, there were no significant effects of APTD on the accuracy of discriminating the temporal order of visual stimuli. This pattern of results does not simply represent an effect of APTD on motor, rather than perceptual, measures of timing because APTD had no effect on participants' ability to use temporal cues to speed RT. Our results demonstrate, for the first time in healthy volunteers, a dopaminergic dissociation in judging metrical (duration) versus ordinal (temporal order) aspects of time.

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Section: Aptd Does Not Impair Temporal Order Processingmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Dopamine Precursor Depletion in Healthy Volunteers Impairs Processing of Duration but Not Temporal Order

Chassignolle

Jovanović

Schmidt-Mutter

et al. 2021

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

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On the Temporal Precision of Thought: Individual Differences in the Multisensory Temporal Binding Window Predict Performance on Verbal and Nonverbal Problem Solving Tasks

Zmigrod

2016

Multisens Res

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Although psychology is greatly preoccupied by the tight link between the way that individuals perceive the world and their intelligent, creative behavior, there is little experimental work on the relationship between individual differences in perception and cognitive ability in healthy populations. Here, individual differences in problem solving ability were examined in relation to multisensory perception as measured by tolerance for temporal asynchrony between auditory and visual inputs, i.e., the multisensory temporal binding window. The results demonstrated that enhanced performance in both verbal and nonverbal problem solving tasks (the Remote Associates Test and Raven’s Advanced Progressive Matrices Task) is predicted by a narrower audio-visual temporal binding window, which reflects greater sensitivity to subtle discrepancies in sensory inputs. This suggests that the precision of individuals’ temporal window of multisensory integration might mirror their capacities for complex reasoning and thus the precision of their thoughts.

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Time Distortions: A Systematic Review of Cases Characteristic of Alice in Wonderland Syndrome

2021

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Of the perceptual distortions characteristic of Alice in Wonderland syndrome, substantial alterations in the immediate experience of time are probably the least known and the most fascinating. We reviewed original case reports to examine the phenomenology and associated pathology of these time distortions in this syndrome. A systematic search in PubMed, Ovid Medline, and the historical literature yielded 59 publications that described 168 people experiencing time distortions, including 84 detailed individual case reports. We distinguished five different types of time distortion. The most common category comprises slow-motion and quick-motion phenomena. In 39% of all cases, time distortions were unimodal in nature, while in 61% there was additional involvement of the visual (49%), kinaesthetic (18%), and auditory modalities (14%). In all, 40% of all time distortions described were bimodal in nature and 19% trimodal, with 1% involving four modalities. Underlying neurological mechanisms are varied and may be triggered by intoxications, infectious diseases, metabolic disorders, CNS lesions, paroxysmal neurological disorders, and psychiatric disorders. Bizarre sensations of time alteration—such as time going backwards or moving in circles—were mostly associated with psychosis. Pathophysiologically, mainly occipital areas appear to be involved, although the temporal network is widely disseminated, with separate component timing mechanisms not always functioning synchronously, thus occasionally creating temporal mismatches within and across sensory modalities (desynchronization). Based on our findings, we propose a classification of time distortions and formulate implications for research and clinical practice.

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Distorted Multisensory Experiences of Order and Simultaneity

Cited by 3 publications

References 134 publications

Dopamine Precursor Depletion in Healthy Volunteers Impairs Processing of Duration but Not Temporal Order

Dopamine Precursor Depletion in Healthy Volunteers Impairs Processing of Duration but Not Temporal Order

On the Temporal Precision of Thought: Individual Differences in the Multisensory Temporal Binding Window Predict Performance on Verbal and Nonverbal Problem Solving Tasks

Time Distortions: A Systematic Review of Cases Characteristic of Alice in Wonderland Syndrome

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