Distinguishing the progression of an endometrioma: Benign or malignant?

Baştu, Ercan; Önder, Semen; Demiral, İrem; Özsürmeli, Mehmet; Keskin, Gulsah; Takmaz, Özgüç; Ozaltin, Selin; Görgen, Hüsnü; Güngör, Mete; Yavuz, Ekrem; Buyru, Faruk

doi:10.1016/j.ejogrb.2018.09.026

Cited by 5 publications

(2 citation statements)

References 65 publications

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“…7 It has also been demonstrated that endometriomas that develop malignant transformation differ from those without malignant transformation using immunohistochemical stains. 8 In addition to this knowledge, we have added that endometriosis may be found in the pathophysiology of SEOC. However, PFS and/or OS did not differ significantly between patients with and without the presence of endometriosis in SEOC.…”

Section: Discussionmentioning

confidence: 99%

Does endometriosis have an effect on the survival of women with synchronous endometrial and ovarian cancer?

Engin

Çelik

Sözen

et al. 2019

Journal of Endometriosis and Pelvic Pain Disorders

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Purpose: Synchronous endometrial and ovarian cancer is defined as the concurrent presence of ovarian cancer with endometrial cancer. We aimed to evaluate whether there is an effect of endometriosis on progression-free survival and overall survival of women with synchronous endometrial and ovarian cancer. We also compared these findings with the patients having endometrial-only tumors and ovarian-only tumors. Methods: The patients who underwent surgery for endometrioid or clear-cell endometrial-only tumors and/or ovarian-only tumors and synchronous endometrial and ovarian cancer between 2005 and 2016 were included in this cohort study. The effect of the presence of endometriosis on progression-free survival and overall survival in these women who met the criteria was determined using statistical methods. Women were also compared regarding their demographic, clinical, and pathological characteristics. Results: A total of 176 patients were included in this study. All histology types of tumors located in endometrium or ovary were endometrioid or clear-cell cancer. Endometriosis was present in 62 patients (35.2%), whereas adenomyosis was present in 44 patients (25%). Endometriosis was diagnosed more frequently in women with ovarian-only tumors and synchronous endometrial and ovarian cancer than those with endometrial-only tumors (59.2% vs 5.7%, p < 0.001 and 45.7% vs 5.7%, p < 0.001, respectively). The patients with endometriosis showed no significantly longer progression-free survival and overall survival (hazard ratio = 1.70; 95% confidence interval = 0.48–6.03; p = 0.408 and hazard ratio = 1.67; 95% confidence interval = 0.30–9.44; p = 0.562, respectively). The presence of endometriosis was a stronger predictor for progression-free survival and overall survival comparing with the presence of adenomyosis. Conclusion: The women with synchronous endometrial and ovarian cancer should be informed that endometriosis has no detrimental effect on progression-free survival and overall survival.

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Section: Discussionmentioning

confidence: 99%

Does endometriosis have an effect on the survival of women with synchronous endometrial and ovarian cancer?

Engin

Çelik

Sözen

et al. 2019

Journal of Endometriosis and Pelvic Pain Disorders

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“…There is an increased lifetime risk of ovarian endometriosis progressing to malignancy of around 1% [20][21][22]. There is genomic and histological data to suggest that malignancy occurs through an intermediate, dysplastic stage called atypical endometriosis [20,[23][24][25][26].There is genomic, gene expression, and immunohistochemical evidence to support the theory that endometriosis is a premalignant condition [27][28][29][30][31][32] (Table 1).…”

Section: Clinical Pathologymentioning

confidence: 99%

Differential Expression of Long Non-coding Ribonucleic Acid (RNA) Genes in Endometriosis-associated Ovarian Cancer (EAOC): A Pilot Meta-analysis for Pathological Insights and Potential Diagnostic Biomarker Identification

Finall,

James,

Quintela-Vazquez

et al. 2022

Journal of Experimental Pathology

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Introduction: Endometrioid and clear cell carcinomas of the ovary are the most common subtypes of epithelial malignancy arising from endometriosis and are often termed endometriosis-associated ovarian carcinomas (EAOCs). There is a paucity of experimental evidence in the medical literature regarding the role of long non-coding ribonucleic acid (RNA) gene expression in the pathogenesis of these carcinomas. Purpose: There is a need to develop understanding of the pathogenesis of these carcinomas for neoplastic risk stratification in endometriosis and to develop novel diagnostic biomarkers. Clear cell carcinoma of the ovary, in particular, has a poor prognosis as a result of resistance to standard platinum-based chemotherapy. Methods: RNAseq datasets from EAOCs were downloaded from Gene Expression Omnibus (GEO) and compared with normal ovarian control sequences using a customized bioinformatic pipeline. Results: We found 88 differentially expressed non-coding RNA molecules present in both endometrioid and clear cell carcinoma types compared with controls. A further 117 were specifically differentially expressed in the endometrioid carcinoma group and 128 in clear cell carcinoma samples alone. Genes of interest for further study from the 88 shared set in both EAOC types include CASC9, RP4-561L24.3, SLC2A1-AS1, LUCAT1, XIST, CASC15, and MIR99AHG. These genes appear to influence ferroptosis as a common pathway. Conclusions: Alterations in the ferroptosis pathway may be a key event in development of EAOC in ovarian endometriosis patients. Further work is required to elucidate the function of the candidate RNA genes identified in this study by in-vitro, cell line and cultured organoid experiments. These candidate RNA gene biomarkers have potential clinical utility in early diagnosis, risk stratification of endometriosis, and post-surgical monitoring.

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The prevalence of endometrioma and associated malignant transformation in women over 40 years of age

Oral

Sozen

Uludağ

et al. 2020

Journal of Gynecology Obstetrics and Human Reproduction

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Distinguishing the progression of an endometrioma: Benign or malignant?

Cited by 5 publications

References 65 publications

Does endometriosis have an effect on the survival of women with synchronous endometrial and ovarian cancer?

Does endometriosis have an effect on the survival of women with synchronous endometrial and ovarian cancer?

Differential Expression of Long Non-coding Ribonucleic Acid (RNA) Genes in Endometriosis-associated Ovarian Cancer (EAOC): A Pilot Meta-analysis for Pathological Insights and Potential Diagnostic Biomarker Identification

The prevalence of endometrioma and associated malignant transformation in women over 40 years of age

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