Distinguish oral-source VOCs and control their potential impact on breath biomarkers

Ge, Dianlong; Zhou, Jijuan; Chu, Yajing; Lü, Yan; Zou, Xue; Xia, Lei; Liu, Yawei; Huang, Chaoqun; Shen, Chengyin; Zhang, Liwei; Wang, Huanzhong; Chu, Yannan

doi:10.1007/s00216-021-03866-8

Cited by 10 publications

(10 citation statements)

References 48 publications

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“…These findings suggested that the effect of gargling on the early peaks in exhalations of the volunteers was largely similar across volunteers, consistent with the rule reflected by other reports. , And it demonstrated that the end-tidal HCN concentration could be measured from the exhalation profile plateau briefly and accurately. Therefore, the plateau could be a good indicator to represent the HCN concentration change in diagnosis, like detecting the PA infection in CF patients.…”

Section: Resultsmentioning

confidence: 99%

Online Detection of HCN in Humid Exhaled Air by Gas Flow-Assisted Negative Photoionization Mass Spectrometry

et al. 2023

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Hydrogen cyanide (HCN) is a well-known toxic compound in many fields. The trace amount of endogenous HCN in human exhalation has been associated with the presence of Pseudomonas aeruginosa (PA) infection in cystic fibrosis (CF) patients. Online monitoring of HCN profile is promising to screen PA infection rapidly and accurately. In this study, a gas flowassisted negative photoionization (NPI) mass spectrometry method was developed for monitoring the single-exhalation HCN profile. The sensitivity could be optimized by introducing helium to eliminate the humidity influence and reduce the low mass cutoff effect, with improvements of a factor 150 observed. By employing a purging gas procedure and minimizing the length of the sample line, the residual and response time were greatly reduced. The limit of detection (LOD) of 0.3 ppbv and time resolution of 0.5 s were achieved. HCN profiles of exhalations from different volunteers before or after gargling with water were detected to show the performance of the method. All profiles showed a sharp peak and a stable end-tidal plateau, representing the concentration of oral cavity and end-tidal gas, respectively. The HCN concentration based on the plateau of the profile showed better reproducibility and accuracy, which indicates this method has potential application in the detection of PA infection in CF patients.

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Section: Resultsmentioning

confidence: 99%

Online Detection of HCN in Humid Exhaled Air by Gas Flow-Assisted Negative Photoionization Mass Spectrometry

et al. 2023

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“…18,19 Research on the development of diagnostic methods based on VOCs has attracted a lot of interest and is indeed growing because these methods are noninvasive or minimally invasive and less expensive compared to biochemical methods, and in many instances, they provide early detection. Reported studies have shown that several analytical methods, including solid-phase microextraction gas chromatography−mass spectrometry (SPME-GC−MS), 12,20 gas chromatography−ion mobility spectrometry (GC-IMS), 21 thermal desorption comprehensive two-dimensional gas chromatography time of flight mass spectrometry (TD-GC × GC-TOFMS), 22 thermal desorption coupled with gas chromatography mass spectrometry (TD-GC−MS), 23 mass spectrometry (GC-QTOF-MS), 24 have been used to identify the VOC biomarkers. Focusing on gastric cancer, Hanna et al 25 could identify 12 VOCs (hexanoic acid, pentanoic acid, methyl phenol, ethyl phenol, phenol, octanal, pentanal, nonanal, butanal, hexanal, heptanal, and decanal) in exhaled breath samples prepared by 81 patients with esophageal or gastric adenocarcinoma using selected ion flow tube mass spectrometry (SIFT-MS).…”

Section: ■ Introductionmentioning

confidence: 99%

“…5−8 GC is more prevalent in men compared to women and causes 760,000 deaths annually. 9,10 In the mid-1980s, volatile organic compounds (VOCs) emitted by various parts of the human body (including blood, 11 exhaled air, 12 saliva, 13 urine, 14 sweat, 15 and tissue samples 16 ) had become an interesting topic in cancer detection as potential biomarkers. 17 It is generally believed that these VOCs are the result of the excessive oxidative reactions that occur in cancer cells.…”

Section: ■ Introductionmentioning

confidence: 99%

Metallic Nanocluster-Based Sniffing Device for Identification of Malignancy in Gastric Cancer Tissues

Sharifi

Tashkhourian

Geramizadeh

et al. 2023

ACS Appl. Nano Mater.

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Analysis of volatile organic compounds (VOCs) emitted from the human organism can provide useful information about normal physiological processes as well as pathological disorders. The aim of this work is to develop a portable, inexpensive, on-site, fast, small design paper-based device based on the electronic nose (E-nose) concept for the detection of malignancy in gastric cancer (GC) by analyzing volatile organic compounds emitted from human tissue. For this purpose, cancerous and noncancerous tissue samples were provided from 22 patients diagnosed with GC, esophageal cancer (EC), and neuroendocrine carcinoma (NEC). In this system, eight types of fluorescent metallic nanoclusters (NCs) as sensing elements were immobilized on a paper substrate. A microcentrifuge tube was used to create a reaction environment to communicate between a paper device containing NCs and VOCs emitted from tissue samples. After exposing the sensors to headspace of the tissues, the emitted VOCs reacted with NCs and led to changes in the fluorescence intensity of NCs. For pattern recognition and statistical analysis, chemometric methods including principal component analysis, linear discriminant analysis, and partial least square discriminant analysis were applied. The sensor array was able to discriminate between fresh cancerous and normal tissues with 95% accuracy. In summary, we fabricated an optical nose device that can sniff the odor of tissues and then identify the malignant tissues in less than 4 h. So, it has the potential for point-of-need applications in the hospital and can offer results in the same time duration required for a patient to recover from anesthesia.

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“… 2 The GC–MS technique involves the sieve sorting of ingredients to separate, identify, and quantify constituents. 3 , 4 This method is time-consuming and expensive, particularly when used for routine analysis. IR techniques combined with sensor test measurements are used to understand interaction mechanisms at the molecular level.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the response of a metal oxide surface strongly depends on the composition of the atmosphere, particularly water and oxygen, which define the baseline for sensor response and calibration . The GC–MS technique involves the sieve sorting of ingredients to separate, identify, and quantify constituents. , This method is time-consuming and expensive, particularly when used for routine analysis. IR techniques combined with sensor test measurements are used to understand interaction mechanisms at the molecular level.…”

Section: Introductionmentioning

confidence: 99%

THz Gas Sensing Using Terahertz Time-Domain Spectroscopy with Ceramic Architecture

Komatsu

Iwamoto²,

Ito

et al. 2022

ACS Omega

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Ceramic architectures based on chemical vapor deposition (CVD) are used to create unique crystal structures, morphologies, and properties. This study proposed room-temperature THz gas sensing using terahertz time-domain spectroscopy (THz-TDS) with ceramic architectures. We synthesized ceramic films on porous glass. Zinc oxide films were created using atmospheric CVD and amorphous carbon nitride films using the dissociative excitation reaction of BrCN with metastable Ar atoms. The transmission method was used in THz-TDS. A stainless hand-made gas cell with a Si window was applied for THz gas sensing. We defined “phase delay” equals VOC sensing response amount of sensing materials at each duration. Ppm-order THz gas sensing was performed.

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Distinguish oral-source VOCs and control their potential impact on breath biomarkers

Cited by 10 publications

References 48 publications

Online Detection of HCN in Humid Exhaled Air by Gas Flow-Assisted Negative Photoionization Mass Spectrometry

Online Detection of HCN in Humid Exhaled Air by Gas Flow-Assisted Negative Photoionization Mass Spectrometry

Metallic Nanocluster-Based Sniffing Device for Identification of Malignancy in Gastric Cancer Tissues

THz Gas Sensing Using Terahertz Time-Domain Spectroscopy with Ceramic Architecture

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