Distinctive Roles of YAP and TAZ in Human Endothelial Progenitor Cells Growth and Functions

Klaihmon, Phatchanat; Lorthongpanich, Chanchao; Kheolamai, Pakpoom; Luanpitpong, Sudjit; Issaragrisil, Surapol

doi:10.3390/biomedicines10010147

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Endothelial cells can sense factors acting on the vascular inner wall, such as fluid shear stress, stretch stress, and extracellular matrix (ECM) hardness, and then release nitric oxide, prostacyclin, reactive oxygen species (ROS), and other vasoactive substances to maintain the normal function of blood vessels (2,3). Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), two closely related transcriptional regulators in the classical Hippo signaling pathway, play a crucial role in organ growth, tissue regeneration, and tumor development through the regulation of diverse transcriptional factors (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

Zhang

Gao

et al. 2022

Front. Cardiovasc. Med.

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Normal endothelial function plays a pivotal role in maintaining cardiovascular homeostasis, while endothelial dysfunction causes the occurrence and development of cardiovascular diseases. Yes-associated protein (YAP) and its homolog transcriptional co-activator with PDZ-binding motif (TAZ) serve as crucial nuclear effectors in the Hippo signaling pathway, which are regulated by mechanical stress, extracellular matrix stiffness, drugs, and other factors. Increasing evidence supports that YAP/TAZ play an important role in the regulation of endothelial-related functions, including oxidative stress, inflammation, and angiogenesis. Herein, we systematically review the factors affecting YAP/TAZ, downstream target genes regulated by YAP/TAZ and the roles of YAP/TAZ in regulating endothelial functions, in order to provide novel potential targets and effective approaches to prevent and treat cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

Zhang

Gao

et al. 2022

Front. Cardiovasc. Med.

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“…Inspiredly, another group delineated the foundational concept and fabrication platform for generating CAR‐NK cells from iPSCs at the single‐cell clone level. [ 87 ] They derived iPSC‐derived CD19 CAR‐NK cells from CD3−CD56+CD16+ NK cells isolated from healthy neonatal UCB. The introduction of three episomal plasmids encoding defined transcription factors, along with an additional plasmid encoding transient EBNA‐1, augmented the reprogramming efficiency.…”

Section: Off‐the‐shelf Car‐based Agentsmentioning

confidence: 99%

Advances in CAR‐Engineered Immune Cell Generation: Engineering Approaches and Sourcing Strategies

Chen,

Hu,

Mei

2023

Advanced Science

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Chimeric antigen receptor T‐cell (CAR‐T) therapy has emerged as a highly efficacious treatment modality for refractory and relapsed hematopoietic malignancies in recent years. Furthermore, CAR technologies for cancer immunotherapy have expanded from CAR‐T to CAR‐natural killer cell (CAR‐NK), CAR‐cytokine‐induced killer cell (CAR‐CIK), and CAR‐macrophage (CAR‐MΦ) therapy. Nevertheless, the high cost and complex manufacturing processes of ex vivo generation of autologous CAR products have hampered broader application. There is an urgent need to develop an efficient and economical paradigm shift for exploring new sourcing strategies and engineering approaches toward generating CAR‐engineered immune cells to benefit cancer patients. Currently, researchers are actively investigating various strategies to optimize the preparation and sourcing of these potent immunotherapeutic agents. In this work, the latest research progress is summarized. Perspectives on the future of CAR‐engineered immune cell manufacturing are provided, and the engineering approaches, and diverse sources used for their development are focused upon.

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“…YAP and TAZ have been reported to play a role in endothelial progenitor cells. Depleting both YAP and TAZ decreased endothelial progenitor cell survival and impaired the critical functions of the cells (migration, invasion, vessel formation, and expression of proangiogenic genes) [ 140 ].…”

Section: Role Of Yap During Hsc Formation and Blood Cell Productionmentioning

confidence: 99%

Role of YAP as a Mechanosensing Molecule in Stem Cells and Stem Cell-Derived Hematopoietic Cells

Damkham

Issaragrisil

Lorthongpanich

2022

IJMS

Self Cite

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Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) are transcriptional coactivators in the Hippo signaling pathway. Both are well-known regulators of cell proliferation and organ size control, and they have significant roles in promoting cell proliferation and differentiation. The roles of YAP and TAZ in stem cell pluripotency and differentiation have been extensively studied. However, the upstream mediators of YAP and TAZ are not well understood. Recently, a novel role of YAP in mechanosensing and mechanotransduction has been reported. The present review updates information on the regulation of YAP by mechanical cues such as extracellular matrix stiffness, fluid shear stress, and actin cytoskeleton tension in stem cell behaviors and differentiation. The review explores mesenchymal stem cell fate decisions, pluripotent stem cells (PSCs), self-renewal, pluripotency, and differentiation to blood products. Understanding how cells sense their microenvironment or niche and mimic those microenvironments in vitro could improve the efficiency of producing stem cell products and the efficacy of the products.

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Distinctive Roles of YAP and TAZ in Human Endothelial Progenitor Cells Growth and Functions

Cited by 4 publications

References 35 publications

The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

The regulation of yes-associated protein/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium

Advances in CAR‐Engineered Immune Cell Generation: Engineering Approaches and Sourcing Strategies

Role of YAP as a Mechanosensing Molecule in Stem Cells and Stem Cell-Derived Hematopoietic Cells

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