Distinctive growth pattern in a patient with a delayed diagnosis of Langerhans’ cell histiocytosis

Abstract

We present a 22-year old male patient previously treated with radiotherapy and surgery at the age of 7 for an undefined suprachiasmatic mass. Following treatment he gradually became morbidly obese and besides subsequent panhypopituitarism he achieved his target height probably due to obesity-induced severe hyperinsulinemia. At the age of 21 Langerhans' cell histiocytosis was diagnosed at the right mandible and was surgically treated. One year later he developed a further painful osteolytic hip lesion and a single zoledronate infusion eliminated all symptoms. We highlight the importance of obtaining a histological diagnosis before initiating treatment, and the distinctive course of the disease in a patient who continued to growth besides GH deficiency.

Langerhans Cell Histiocytosis in a 5-Year-Old Girl: A Case Report and Review of Literature

“…Adult aged 77 years a. Mandible b. Hard palate Shetty et al 2012 [25] 1 Child aged 14 years Bilateral maxilla Aydin et al 2012 [26] 1 Adult aged 45 years Mandible Anastasilakis et al 2012 [27] 1 Adult aged 21 years Mandible Martin et al 2011 [28] 1 Infant aged 4 months Mandible Murray et al 2011 [29] 1 Infant aged 22 months Maxilla, mandible, and hard palate Bas et al 2011 [30] 1 Child aged 7 years Mandible Dholam et al 2011 [31] 1 Child aged 12 years Mandible Alloh Amichia et al 2010 [32] 1 * Jaw Muramatsu et al 2010 [33] 1 Infant aged 13 months Mandible Park and Chung 2010 [34] 1 Child aged 1 year Mandibular condyle Gaundong Mbéthé et al 2010 [35] 2 * Jaw Altug et al 2010 [36] 1 Adult aged 20 years Mandible Esen et al 2010 [37] 1 * Mandible Bouw and Nout 2009 [38] 1 Infant aged 6 months Maxilla Rees and Paterson 2009 [39] 1 Adult aged 31 years Jaw Helbling-sieder et al 2009 [40] 1 Adult aged 27 years Mandible Guiglia et al 2009 [41] 1 Child aged 13 years Mandible Orzechowska-Wylegała et al 2008 [42]…”