Distinctive clinical and microscopic features of squamous cell carcinoma of oral cavity and lip

Batista, Aline Carvalho; Costa, Nádia Lago; Oton-Leite, Angélica Ferreira; Mendonça, Elismauro Francisco; Alencar, Rita de Cássia Gonçalves; Silva, Tarcı́lia Aparecida

doi:10.1016/j.tripleo.2009.10.034

Cited by 38 publications

(60 citation statements)

References 32 publications

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“…This study grouped lateral border and ventral surface of the tongue because many times both sites are concurrently affected. Mostly confirming the literature data, the tongue OSCCs in this study were more painful, frequently presenting lymph node involvement, and at least a T2 tumor or more (16,20). Similar positive and statistically significant associations were observed also for gingiva/alveolar ridge and floor of the mouth.…”

Section: Discussionsupporting

confidence: 91%

“…One point that should be emphasized is that the lesions in the lip are promptly detected by self-examination compared with the intraoral lesions, which explains their minor size and by consequence have the lowest symptomatology and lowest incidence of cervical metastasis, which also allows for early diagnosis and better prognosis (9,10,16,18,20). The study results confirmed the reduced aggressiveness of LSCC, compared with intraoral cancer (20).…”

Section: Discussionsupporting

confidence: 65%

“…The major frequency of OSCC lesions in this site has great relevance when the studies are performed in tropical countries, in addition to the important influence by socio-demographic (like ethnic origin), main occupation and cultural aspects of the studied population (10,16,20).…”

Section: Discussionmentioning

confidence: 99%

“…Although the biopsy registers do not provide the occupation of the retired patients, it is possible that most of them live in rural areas, which would reinforce this correlation. Moreover, the lower lip is subjected to intense and chronic sun exposure and thus ultraviolet (UV) radiation, which may contribute to it being the most common site for OSCC in males and in populations of fair-skinned people (16,20,21). For women, the use of lipstick could be considered as a potential protective factor (17).…”

Section: Discussionmentioning

confidence: 99%

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Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population

et al. 2017

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The aim of this study was to evaluate the demographic and clinical profile of the oral squamous cells carcinoma (OSCC) cases registered in a center of oral diagnosis in southern Brazil. Eight hundred and six individuals with OSCC from 1959 to 2012 were included in this study. The variables recorded were: sex, age, occupation according to workplace, alcohol and tobacco consumption, skin color, tumor location, histological type, clinical appearance, size, evolution time, presence of pain and lymph node metastasis. Descriptive analysis was performed and the associations between variables were assessed using the chi-square and Fisher's exact test, with a confidence level of 5%. OSSC was more common in males (76.6%) aged between 51 to 70 years (53.9%). The most frequent sites were lower lip vermilion (23.3%), tongue (20.2%) and gingiva/alveolar ridge (18.1%). There was a strong association between outdoor occupation and white skin color with lip squamous cell carcinoma (LSCC). OSCC intraoral lesions were commonly more painful, larger than 2 cm and presented lymphatic metastasis. In conclusion, most of the results confirm the data from literature about sex, age, tumor location and occupation. Moreover, the positive correlations between LSCC and occupation, between LSCC and white skin color, and between bigger lesions and presence of pain/cervical metastasis also corroborate the literature data.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population

et al. 2017

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“…Twenty nine out of 42 patients (69%) with oropharyngeal cancers had cervical lymphadenopathy on presentation. The results were similar to most of the studies in the past (Rivera et al;Batista et al, 2010). The presence or absence of metastatic lymphadenopathy has been reported to be the single most important prognostic factor for these cancers (Jerjes et al;Rapoport et al, 2009).…”

Section: Discussionsupporting

confidence: 90%

Oral and Oropharyngeal Squamous Cell Carcinoma in Our Population: The Clinic-Pathological and Morphological Description of 153 Cases

Agarwal¹,

Sethi²,

Sareen³

et al. 2011

Int. J. Morphol.

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SUMMARY:Oral cavity and oropharynx are one of the commonest sites for cancers in our population due to a high prevalence of tobacco use, especially chewing, in our country. The objective of this study was to prospectively assess the clinico-pathological and morphological aspects of the patients presenting to us with these malignancies. We studied 153 patients with oral and oropharyngeal squamous cell carcinoma who were managed in the department of otolaryngology and head and neck surgery between January 2006 and December 2007 at Maulana Azad Medical College and associated hospitals in New Delhi. There were 127 male patients (83%) and 26 females (17%) with ages ranging from 22 years to 70 years. One hundred and eleven patients (73%) presented with oral cavity and 42 patients (27%) with oropharyngeal carcinomas. Most common site of presentation in the oral cavity was the buccal mucosa, whereas, base of tongue was the commonest site in the oropharynx. Amongst the oral cavity cancers, 51 each (46% each) were well differentiated and moderately differentiated, whereas, 9 (8%) were poorly differentiated cancers. However, amongst the oropharyngeal cancers, 27 (64%) were moderately differentiated and 15 (36%) were poorly differentiated. Overall, 73 patients presented with lymphadenopathy on presentation, out of which, 44 patients were those with oral cavity and 29 with oropharyngeal cancers. There was a significant correlation between the site (i.e. oral cavity or orophaynx) and lymphadenopathy on presentation. Fifty nine patients (39%) presented to us with early stage disease (i.e. stage I and II), whereas, 94 patients (61%) presented with late stage disease (i.e. stage III and IV). There was a significant correlation between the site (i.e. oral cavity or oropharynx) and stage at presentation.

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Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer

et al. 2014

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Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal-Wallis and Dunn's tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3-1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3-1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed.

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Distinctive clinical and microscopic features of squamous cell carcinoma of oral cavity and lip

Cited by 38 publications

References 32 publications

Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population

Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population

Oral and Oropharyngeal Squamous Cell Carcinoma in Our Population: The Clinic-Pathological and Morphological Description of 153 Cases

Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer

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