Distinction of dermal conditions related to collagen state using THz spectroscopy

Mizuno, Maya; Yaekashiwa, Noriko; Watanabe, Soichi

doi:10.1109/irmmw-thz.2017.8067197

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2018

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“…The absorption magnitude of the epidermis model agreed with that of 60% liquid water, whereas the absorption magnitude of the dermis disagreed with that of 67% water at higher frequencies. The result of the epidermis model agreed with that of the porcine epidermis [18] regardless of the tissue level. At higher frequencies, the absorption of proteins such as collagen can be observed [19].…”

Section: Measurement Resultssupporting

confidence: 75%

Analysis of dermal composite conditions using collagen absorption characteristics in the THz range

Mizuno¹,

Yaekashiwa²,

Watanabe³

2018

Biomed. Opt. Express

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Abstract:The absorption characteristics of the dermis were reviewed in the terahertz range from 0.2 to 2 THz. The absorption magnitude of the dermis was higher than that of the epidermis model owing to the inclusion of collagen fibers. The heat denaturation of the collagen and the decrease of water content in the dermis caused a decrease in the absorption magnitude of the dermis. We verified that the absorption magnitude of collagen sheets at 1 THz similarly decreased by nearly 43% upon the heat treatment at approximately 70° C. When the heat-treated sheet was used as a scaffold for cell culture, the average growth rate of the fibroblast increased. These findings suggest that variation in the ability of cell growth in the dermis can be predicted using the absorption of the collagen or the difference between the absorptions of dermis and water.

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Section: Measurement Resultssupporting

confidence: 75%