Analysis of dermal composite conditions using collagen absorption characteristics in the THz range

Mizuno, Maya; Yaekashiwa, Noriko; Watanabe, Soichi

doi:10.1364/boe.9.002277

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Collagen absorbs THz radiation, thus providing data about the tissue structure and enrolled processes. 101 Far-infrared spectroscopy was able to detect the collagen amount and its spectral shape changes after the addition of a salt solution. 102 TPS allowed for detection of different salt concentrations in the collagen layers and drug absorption in the skin.…”

Section: Thz Instrumentationmentioning

confidence: 99%

Terahertz radiation and the skin: a review

et al. 2021

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Significance: Terahertz (THz) radiation has demonstrated a great potential in biomedical applications over the past three decades, mainly due to its non-invasive and label-free nature. Among all biological specimens, skin tissue is an optimal sample for the application of THz-based methods because it allows for overcoming some intrinsic limitations of the technique, such as a small penetration depth (0.1 to 0.3 mm for the skin, on average). Aim: We summarize the modern research results achieved when THz technology was applied to the skin, considering applications in both imaging/detection and treatment/modulation of the skin constituents. Approach: We perform a review of literature and analyze the recent research achievements in THz applications for skin diagnosis and investigation. Results: The reviewed results demonstrate the possibilities of THz spectroscopy and imaging, both pulsed and continuous, for diagnosis of skin melanoma and non-melanoma cancer, dysplasia, scars, and diabetic condition, mainly based on the analysis of THz optical properties. The possibility of modulating cell activity and treatment of various diseases by THz-wave exposure is shown as well. Conclusions: The rapid development of THz technologies and the obtained research results for skin tissue highlight the potential of THz waves as a research and therapeutic instrument. The perspectives on the use of THz radiation are related to both non-invasive diagnostics and stimulation and control of different processes in a living skin tissue for regeneration and cancer treatment.

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Section: Thz Instrumentationmentioning

confidence: 99%

Terahertz radiation and the skin: a review

et al. 2021

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“…The simulation used the real (ε ) and imaginary (ε ) parts of the complex permittivity to specify the tissue dielectric properties. The ε' and ε" for the skin components are based on available published data [35][36][37][38][39][40][41][42][43][44]. The lack of direct data necessitated use of data for tissue components rather than whole tissues and applying mixing formulae based on water content [37,45,46] to determine dielectric values.…”

Section: Transmission Absorption and Thermal Characteristicsmentioning

confidence: 99%

Computational absorption and reflection studies of normal human skin at 0.45 THz

Vilagosh

Lajevardipour

Wood

2019

Biomed. Opt. Express

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Applications using terahertz (THz) frequency radiation will inevitably lead to increased human exposure. The power density and specific absorption rate (SAR) simulations of thin skin at 0.45 THz show the bulk of the energy being absorbed in the upper stratum spinosum, and the maximal temperature rise is in the lower stratum spinosum. There are regions of SAR increase of 100% above the local average at the stratum spinosum/stratum basale boundary. The dead Stratum Corneum layer protects underlying tissues in thick skin. Reflection studies suggest that acute angles and the use of polarised incident radiation may enhance the assessment of diabetic neuropathy.

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“…The dielectric values, expressed as the real ( ϵ ′) and imaginary ( ϵ ″) parts of the complex permittivity, refractive index, and absorption coefficient, are set out in Table . The values are derived from data from Huang et al [], Jördens et al [], Png et al [], Sy et al [], Sim et al [,], Guseva et al [], Yamaguchi et al [], Hernandez‐Cardoso et al [], Hübers et al [], and Mizuno et al [], and the analysis of mixing formulae is from Jördens et al [] and Ney and Abdulhalim []. A comprehensive outline of the derivation is provided in the supplementary material (S2).…”

Section: Introductionmentioning

confidence: 99%

“…The stratum corneum has only 15% water content, and thus ϵ ″ remains high in the model. The values are derived from Huang et al [], Jördens et al [], Png et al [], Sy et al [], Sim et al [,], Guseva et al [], Yamaguchi et al [], Hernandez‐Cardoso et al [], Hübers et al [] and Mizuno et al [].…”

Section: Introductionmentioning

confidence: 99%

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

Vilagosh

Lajevardipour

Wood

2019

Bioelectromagnetics

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Terahertz radiation (THz) is highly absorbed by liquid water. This creates the possibility of medical imaging on the basis of the water content difference between normal and diseased tissue. The effective penetration of THz is limited, however, to a tissue depth of 0.2–0.3 mm at body temperature. A unique feature of the 0.1–2.0 THz frequency is that there is a high disparity between liquid water absorption and ice absorption, with ice being 100 times more permeable to the radiation than liquid water. This results in 90% of the radiation surviving to 1.0 mm in ice, permitting the imaging of frozen tissues to a depth of 5.0 mm. This method is practical as an in vivo procedure before or during surgical excision. Finite difference time domain (FDTD) computational modeling of frozen normal skin and frozen melanoma was undertaken using tissue phantoms. The study suggests that sufficient contrast exists to differentiate normal frozen skin and melanoma on the basis of the difference of water content alone. When the melanin pigment in melanomas is modeled as a significant absorber of THz, the contrast changes. Based on the modeling, further exploration of the “THz‐skin freeze” imaging technique is justified. In the modeling, the boundary between the frozen tissue and non‐frozen tissue is shown to be strongly reflective. If the reflective properties of the boundary are substantiated, the “THz‐skin freeze” technique will have applications in other areas of skin diagnostics and therapeutics. Bioelectromagnetics. 40:118–127, 2019. © 2019 Bioelectromagnetics Society

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Analysis of dermal composite conditions using collagen absorption characteristics in the THz range

Cited by 10 publications

References 20 publications

Terahertz radiation and the skin: a review

Terahertz radiation and the skin: a review

Computational absorption and reflection studies of normal human skin at 0.45 THz

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

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