Distinct Types of Lipofuscin Pigment in the Hippocampus and Cerebellum of Aged Cheirogaleid Primates

Gilissen, Emmanuel; Staneva-Dobrovski, Ludmilla

doi:10.1002/ar.22809

Cited by 23 publications

(26 citation statements)

References 94 publications

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“…Similar results have been found in other species (7). Lipofuscin deposits may be even found in basket or stellate cells (11). In humans, at the young age (2-6 years) no or few deposits of LF are observed.…”

Section: Discussionsupporting

confidence: 86%

“…It has been shown to be more intense in the phylogenetically older structures of the central nervous sys-tem. Besides, the higher the activity of the brain structure, the more intense is lipofuscinogenesis (11). Therefore, as previously described, PC of neocerebellum predominantly did not contain LF inclusions, or only discrete diffusely distributed LF granules were present after the age of 50.…”

Section: Discussionsupporting

confidence: 69%

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Lipofuscin Accumulation in Purkinje Cells as a Marker of Cerebellum Aging

Živković¹,

Stojanović²,

Pavlović³

et al. 2017

amm

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Lipofuscin has been known as an "age pigment". The aim of this study was to determine the patterns of lipofuscin accumulation in cerebellum Purkinje cells during the process of aging, as well as the Purkinje cell volume density. The cerebellar tissue samples taken from cadavers were divided into four age groups. Stained tissue samples were analyzed for lipofuscin distribution patterns. Morphometric analysis included the quantification of Purkinje cell volume density. Purkinje cells of neocerebellum predominantly did not contain lipofuscin inclusions, or only discrete diffusely distributed lipofuscin granules were present after the age of 50. Even after 70 years of age, not many cells contained lipofuscin. Besides, no significant changes in the volume density of Purkinje cells were observed. Physiological changes in the elderly associated with cerebellum function impairment may be related to the increased lipofuscinogenesis in Purkinje cells after the age of 50, but especially after the age of 70 years. Acta Medica Medianae 2017;56(4):70-74.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 69%

Lipofuscin Accumulation in Purkinje Cells as a Marker of Cerebellum Aging

Živković¹,

Stojanović²,

Pavlović³

et al. 2017

amm

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“…Gilissen and Bobrovski [28] stated that the important causal factor of lipofuscinogenesis involves free radicalinduced lipid peroxidation and oxidative enzymatic activity. A high rate of cellular activity may also cause an increased turnover of cellular products resulting in lipofuscin accumulation.…”

Section: Discussionmentioning

confidence: 99%

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

Altayeb

Salem

2017

Journal of Medical Histology

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Background: Modern society is full of stress. Immobilization stress is a model used in animals to study its effects. Vitamin E is an antioxidant that protects biological membranes from oxidative stress. Objectives: This study aimed to investigate the effects of immobilization stress on the adrenal cortex of rats and the ameliorative effect of vitamin E. Materials and Methods: Forty adult male rats were used in this study and were divided equally into 4 groups. Group I: were divided equally into negative and positive controls. Group II: rats received vitamin E at a dose of 40 I.U/kg by gastric tube for 30 days. Group III: rats subjected to immobilization stress 2 hours /day for 30 days. Group IV: rats subjected to immobilization stress 2 hours /day and received 40 I.U/kg of vitamin E for 30 days. Adrenal sections were histologically prepared and examined. Results: Group II was comparable to group IA. Group III revealed zona glomerulosa (ZG) with loss of normal architecture, zona fasciculata (ZF) with multiple cells containing cytoplasmic vacuolations and darkly stained nuclei. By EM ZG cells appeared with accumulations of lipid droplets and lysosomes, irregular nuclear envelopes and chromatin condensation. ZF cells showed numerous lipid droplets and irregular nuclear envelopes. There were significant increases in the mean area of collagen fibers and mean serum cortisol level. Group IV revealed regression of these changes and increase in the mean count of CD44 +ve cells. Conclusions: Immobilization stress exerted deleterious suprarenal cortical changes and vitamin E had an ameliorative effect.

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“…The color of emission varies with age (from immature pigment to mature pigment) of the individual bearing it [13]. The rate of lipofuscin accumulation has been reported to vary in different species [14], in different tissues of the same species [14,15], and even different regions of the same organ [16][17][18], The rate of lipofuscin accumulation is high in short-lived mammals like mouse and rat as compared to long-lived species due to highly active mitochondria, which produce more superoxide and hydrogen peroxide radicals [15,19].…”

Section: Introductionmentioning

confidence: 99%

A Sequential Study of Age-Related Lipofuscin Accumulation in Hippocampus and Striate Cortex of Rats

Kushwaha

Patro

2018

Ann Neurosci

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Background: The age-pigment, lipofuscin that accumulates in cells intrinsically and progressively with age is considered as the hallmark of aging. This accumulation is more prominent in post-mitotic cells like neurons and also appears in glia. Purpose: The aim of the present study was to assess the age-associated occurrence and distribution pattern of lipofuscin both in neurons and microglia in various regions of hippocampus and striate cortex. Methods: The accumulation pattern of lipofuscin in hippocampus and striate cortex was observed in the female Wistar rats of 6 age groups, that is, 3, 6, 12, 18, 24, and 30 months using the autofluorescent property of lipofuscin and its specific localization in neurons and microglia by dual immunolabeling with NeuN and Iba-1 antibodies respectively. Cytoarchitectural and the morphological age-related changes were observed with cresyl violet staining. Results: Lipofuscin pigments accumulate progressively through the normal aging process in hippocampus and striate cortex. However, in hippocampus, lipofuscin accumulates in a region-specific manner with the highest accumulation observed in cornu ammonis (CA) 1 and 3 subregions. Furthermore, the lipofuscin accumulation was also observed in microglia in the senile brains both in the hippocampus and striate cortex. Conclusion: The progressive deposition of lipofuscin could result in cellular dysfunction. This encouraged us to forward the idea that microglia not only participate in the removal of the pigment from the neurons but also accumulate these waste products in itself. Such senescent microglia may contribute to age- related neurodegeneration as they lose the neuroprotective potential due to oxidative stress and thus may be unable to effectively phagocytose the age pigment.

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Distinct Types of Lipofuscin Pigment in the Hippocampus and Cerebellum of Aged Cheirogaleid Primates

Cited by 23 publications

References 94 publications

Lipofuscin Accumulation in Purkinje Cells as a Marker of Cerebellum Aging

Lipofuscin Accumulation in Purkinje Cells as a Marker of Cerebellum Aging

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

A Sequential Study of Age-Related Lipofuscin Accumulation in Hippocampus and Striate Cortex of Rats

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