Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

Zhu, Xia; Tang, Hao-Di; Dong, Wanying; Kang, Fang; Liu, An; Mao, Yu; Xie, Wen; Zhang, Xulai; Cao, Peng; Zhou, Wenjie; Ht, Wang; Farzinpour, Zahra; Tao, Wenjuan; Song, Xiaoyuan; Zhang, Yan; Xue, Tian; Jin, Yan; Li, Juan; Zhang, Zhi

doi:10.1038/s41593-021-00811-x

Cited by 73 publications

(64 citation statements)

References 60 publications

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“…Consistently, previous tracing and electrophysiological studies showed that the Po receives pruriceptive information from the spinothalamic and trigeminothalamic tracts (Chiaia et al, 1991;Gauriau and Bernard, 2004;Lipshetz and Giesler, 2016; Moser and Giesler, 2014;Veinante et al, 2000;Zhang and Giesler, 2005). VB thalamus and Po are also involved in the processing of pain (Saade ´et al, 2006;Zhang et al, 2017;Zhu et al, 2021). It is likely that thalamic neurons process different somatosensory submodalities with population coding, given that most spinothalamic tract neurons are responsive to multiple types of stimuli (Simone et al, 2004).…”

Section: Introductionsupporting

confidence: 54%

Circuit Mechanisms of Itch in the Brain

Sun

2022

Journal of Investigative Dermatology

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Section: Introductionsupporting

confidence: 54%

Circuit Mechanisms of Itch in the Brain

Sun

2022

Journal of Investigative Dermatology

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“…Thalamic inhibition is a critical element of thalamic projection neurons interactions, and evidence for its perturbation is found in many diseases, including both pain and itch ( Halassa and Acsady, 2016 ; Steinhoff et al., 2018 ). Recent studies have also identified that the posterior thalamic nucleus (Po) and the zona incerta-Po inhibitory projection modulate nocifensive behaviors ( Wang et al., 2020 ; Zhu et al., 2021 ). Most VB neurons are excitatory neurons, and the best-studied source of VB inhibition is derived from the TRN ( Halassa and Acsady, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Modulation of itch and pain signals processing in ventrobasal thalamus by thalamic reticular nucleus

Liu

Wang

et al. 2022

iScience

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Summary Thalamic reticular nucleus (TRN) is known to be crucial for dynamically modulating sensory processing. Recently, the functional role of TRN in itch and pain sensation processing has drawn much attention. We found that ventrobasal thalamus (VB) neurons exhibited scratching behavior-related and nociceptive behavior-related neuronal activity changes, and most of VB neurons responsive to pruritic stimulus were also activated by nociceptive stimulus. Inhibition of VB could relieve itch-induced scratching behaviors and pathological pain without affecting basal nociceptive thresholds, and activation of VB could facilitate scratching behaviors. Tracing and electrophysiology recording results showed that VB mainly received inhibitory inputs from ventral TRN. Furthermore, optogenetic activation of TRN-VB projections suppressed scratching behaviors, and ablation of TRN enhanced scratching behaviors. In addition, activation of TRN-VB projections relieved the pathological pain without affecting basal nociceptive thresholds. Thus, our study indicates that TRN modulates itch and pain signals processing via TRN-VB inhibitory projections.

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“…Some of its features include delivery of sensory signals, regulation of sleep, consciousness, alertness, emotion, and function of memory [56][57][58][59][60] (Table 4). Damage to the thalamus can lead to various serious consequences, such as sensory deficits, permanent coma, episodic event memory deficits and so on [57,58,60] (Table 4).…”

Section: Emotion-related Functional Zonementioning

confidence: 99%

“…It seemed to indicate abnormalities in the emotional processing associated with the colliculi-pulvinar pathway. An experiment with a mouse model of depression has revealed the thalamus mediated allodynia, which based on a depression-like state, was associated with the anterior cingulate cortex [59].…”

Section: Emotion-related Functional Zonementioning

confidence: 99%

Analysis of interhemispheric functional connectivity with the congenital blindness: interactions between blindness and emotional regulation

Kang

Pan

Kang

et al. 2022

Preprint

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Purpose Negative emotions, as an important risk factor, promote the development of many diseases. The study is designed to discuss alterations of interhemispheric functional connectivity (FC) with congenital blindness (CB) subjects by adopting voxel-mirrored homotopic connectivity (VMHC). Based on the alterations in FC, we assessed whether there was an interaction between blindness and emotional regulation. Method VMHC values were collected from 24(males/females = 9/15) subjects with congenital blindness and 24(males/females = 9/15) healthy controls. The gender, age and other information of the healthy controls were closely matched with the disease group. The VMHC values were applied to assess alterations in hemispheric FC between the two groups. Receiver Operating Characteristic (ROC) were applied so as to classify the mean VMHC values of the CB and HC subjects. In addition, an evaluation, which was applied the Pearson Correlation analysis, was employed to compare the correlation between VMHC values of specific brain areas and clinical features of CB subjects. Result The area under curve (AUC) was 0.8750 (P < 0.0001) for bilateral fusiform gyrus (FFG), 0.9670 (P < 0.0001) for bilateral superior occipital gyrus (SOG), 0.9653 (P < 0.0001) for bilateral thalamus (THA) and 0.9462 (P < 0.0001) for bilateral paracentral lobule (PCL). Furthermore, anxiety scores (AS) and depression scores (DS) displayed a positive correlation with the VMHC values of bilateral thalamus (r =− 0.943; P< 0.001 and r = 0.869; P< 0.001) in CB group. Conclusion In the CB group, aberrant interhemispheric FC was observed in specific cerebral regions. These altered VMHC values in the cerebral areas might be potential diagnostic markers of emotional disorders and aberrant brain activities in the CB patients. Humanistic care and necessary psychological treatment for blind patients may be one of the measures to prevent vision from persistent loss in the future. At the same time, the changes of brain function may also provide new ideas for individualized treatment of patients with anxiety, depression and other emotional disorders.

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Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

Cited by 73 publications

References 60 publications

Circuit Mechanisms of Itch in the Brain

Circuit Mechanisms of Itch in the Brain

Modulation of itch and pain signals processing in ventrobasal thalamus by thalamic reticular nucleus

Analysis of interhemispheric functional connectivity with the congenital blindness: interactions between blindness and emotional regulation

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