Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy

Weber, Bernd; Lüders, Eileen; Faber, Jennifer; Richter, Sabine; Quesada, Carlos M.; Urbach, Horst; Thompson, Paul M.; Toga, Arthur W.; Elger, Christian E.; Helmstaedter, Christoph

doi:10.1093/brain/awm186

Cited by 53 publications

(37 citation statements)

References 24 publications

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“…Weber et al demonstrated a decrease in the thickness of posterior collosal areas in epilepsy. In this study, a decrease was observed in posterior colossal areas' thicknesses in patients who had early starting age and had especially left hemisphere diagnosis (28). In another study conducted with epileptic rats whose temporal lobe cortex was exposed to damage, a decrease in hearing ability and a noticeable decrease in cortex thickness was observed (10,15).…”

Section: -363 Kurkcuoglu a Et Al: Stereological Evaluation Of Temsupporting

confidence: 50%

Stereological evaluation of temporal lobe / telencephalon volume in temporal lobe epilepsy using cavalieri principle

Kürkçüoğlu¹,

Zağyapan²,

Pelin³

2010

Turkish Neurosurgery

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AIM:Epilepsy is a temporary electric discharge in the brain cells due to shortterm brain function disorder. Epileptic seizures mostly stem from the temporal lobe. The prevalence is the same for women and men. It is thought that there are both microscopic-and macroscopic-level localized changes in the temporal lobe epilepsy. This study aims to assess the volumetric changes that might occur in temporal lobe epilepsy and compare these with normal brains. MATERIAL and METHODS: Volumetric assessment of temporal lobes and telencephalons was performed using the stereological method on the magnetic resonance images (MRI) of 30 female temporal lobe epilepsy patients and 30 healthy females (control group). The volume ratio of temporal lobe to the whole telencephalon was calculated by means of the Cavalieri principle over the coronal MR images of all participants. The section images were transformed into a series of images by Image j program and the measurements were performed by using a point grid. RESULTS:The patient group's temporal lobe/telencephalon volumetric ratios were found to be significantly lower than that of the normal participants. CONCLUSION: The pattern of temporal lobe volume decrease in TLE may be due to a combined effect of the electrical discharges during seizures and secondary damage due to disconnection. KEYWORDS: Temporal lobe epilepsy, Magnetic resonance imaging, Temporal lobe, Stereology ÖZ AMAÇ: Epilepsi kısa süreli beyin fonksiyon bozukluğuna bağlı beyin hücrelerinde geçici anormal elektrik yayılmasıdır. Epilepsi nöbetleri en çok temporal lobdan kaynaklanmaktadır. Kadın ve erkeklerin hastalığa yakalanma oranları eşittir. Temporal lob epilepsisinde beyinde gerek mikroskobik gerekse makroskobik düzeyde lokalize değişikliklerin olduğu düşünülmektedir. Bu çalışmanın amacı, Temporal lob epilepsili hastaların beyinlerinde oluşabilecek hacimsel değişikliklerin değerlendirilmesi ve bunların normal beyinler ile karşılaştırılmasıdır. YÖNTEM ve GEREÇ: Çalışma Temporal lob epilepsili erişkin 30 kadın hasta ve 30 sağlıklı kadın (kontrol grubu) üzerinde gerçekleştirildi. Bireylerin hiçbirinde yer kaplayan lezyon veya serebrovasküler bir hastalık bulunmamaktaydı. Tüm bireylerin koronal düzlemde alınmış MR görüntüleri üzerinden stereolojik olarak Cavalieri prensibi kullanılarak temporal lobun tüm telensefalona olan hacim oranı hesaplandı. Kesit görüntüleri Imaje j programında görüntü dizisi haline getirildi ve noktalı alan ölçüm cetveli kullanılarak ölçümler gerçekleştirildi. BULGULAR: Hasta bireyler ile normal kişilerin temporal lob/telencephalon hacimsel oranları karşılaştırıldığında hasta grupta hacimsel oranların sağlıklı gruba göre anlamlı olarak düşük olduğu tesbit edildi. SONUÇ: Temporal lob epilepsisinde temporal lob hacmindeki azalmanın sebebi anormal elektiriksel deşajların beyinde verdiği etkiye bağlı olabilir.

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Section: -363 Kurkcuoglu a Et Al: Stereological Evaluation Of Temsupporting

confidence: 50%

Stereological evaluation of temporal lobe / telencephalon volume in temporal lobe epilepsy using cavalieri principle

Kürkçüoğlu¹,

Zağyapan²,

Pelin³

2010

Turkish Neurosurgery

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“…In addition, microstructural changes of the corpus callosum were demonstrated in patients with acquired epilepsy by several studies using DTI and volumetric methods (Kim et al, 2008;Weber et al, 2007). However, although abnormalities of the corpus callosum were frequently reported in patients with epilepsy, it has not been determined whether abnormalities of the corpus callosum were the result or cause of epilepsy.…”

Section: Discussionmentioning

confidence: 99%

“…Many of the studies regarding brain connectivity in epilepsy have demonstrated that focal epilepsy is associated with increases in regional connectivity at the epileptogenic zone, paired with diminished global connectivity (Englot et al, 2016;Kim, Piao, Liu, Bingaman, & Diehl, 2008;Liu et al, 2015;Miro et al, 2015;Weber et al, 2007). However, few studies have investigated the response to AEDs according to brain connectivity, although the number of studies examining brain connectivity in epilepsy has grown rapidly in recent years (Hu et al, 2015;Szaflarski, Kay, Gotman, Privitera, & Holland, 2013).…”

Section: Introductionmentioning

confidence: 99%

Can we predict drug response by volumes of the corpus callosum in newly diagnosed focal epilepsy?

Kim

Lee

et al. 2017

Brain and Behavior

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Objective: The aim of this study was to investigate whether volumes of the corpus callosum could predict a response to antiepileptic drugs in patients with newly diagnosed focal epilepsy. Methods:Fifty-three patients with newly diagnosed focal epilepsy of unknown etiology and healthy subjects were enrolled in this study. First, we analyzed the differences in the volumes of the corpus callosum between patients with epilepsy and healthy subjects. Second, we divided patients with epilepsy into antiepileptic drug responders and drug nonresponders groups, according to their seizure controls, and evaluated the differences in the volumes of the corpus callosum between the groups. Third, we conducted correlation analyses between the volumes of the corpus callosum and mean diffusion measures in healthy subjects. Results:The volumes of the corpus callosum in patients with epilepsy were significantly lower than those in normal controls (p = .0001). Among epilepsy patients, the volumes of the corpus callosum were significantly lower in antiepileptic drug responders compared with nonresponders (p = .0481), which was the only independent variable for predicting antiepileptic drug response (OR = 10.07, p = .0434). In addition, we found that the volumes of the corpus callosum were significantly correlated with the mean diffusion measures (fractional anisotropy, r = .408, p = .0027; mean diffusivity, r = −0.403, p = .0028) in normal controls. Conclusions:We demonstrated that the volumes of the corpus callosum were different according to antiepileptic drug responses in patients with newly diagnosed focal epilepsy, which might suggest that the volumes of the corpus callosum could be a new biomarker for predicting responses to antiepileptic drugs. K E Y W O R D Santiconvulsants, corpus callosum, epilepsy

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“…It is also conjectured that the size and shape of the corpus callosum reflects certain human characteristics (such as a mathematical or musical ability). Several studies indicate that the size and shape of the corpus callosum, in humans, is correlated to gender [7,28], age [28,31], brain growth and degeneration [12,22], handedness [6], epilepsy [5,26,30] and brain dysfunction [8,17]. Fig.…”

Section: Mri Scan Categorisationmentioning

confidence: 99%

Time Series Case Based Reasoning for Image Categorisation

Elsayed

Hijazi

Coenen

et al. 2011

Case-Based Reasoning Research and Development

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Abstract. This paper describes an approach to Case Based Reasoning (CBR) for image categorisation. The technique is founded on a time series analysis mechanism whereby images are represented as time series (curves) and compared using time series similarity techniques. There are a number of ways in which images can be represented as time series, this paper explores two. The first considers the entire image whereby the image is represented as a sequence of histograms. The second considers a particular feature (region of interest) contained across an image collection, which can then be represented as a time series. The proposed techniques then use dynamic time warping to compare image curves contained in a case base with that representing a new image example. The focus for the work described is two medical applications: (i) retinal image screening for Age-related Macular Degeneration (AMD) and (ii) the classification of Magnetic Resonance Imaging (MRI) brain scans according to the nature of the corpus callosum, a particular tissue feature that appears in such images. The proposed technique is described in detail together with a full evaluation in terms of the two applications.

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Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy

Cited by 53 publications

References 24 publications

Stereological evaluation of temporal lobe / telencephalon volume in temporal lobe epilepsy using cavalieri principle

Stereological evaluation of temporal lobe / telencephalon volume in temporal lobe epilepsy using cavalieri principle

Can we predict drug response by volumes of the corpus callosum in newly diagnosed focal epilepsy?

Time Series Case Based Reasoning for Image Categorisation

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