Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD)

Suda, Takafumi; Kono, Masato; Nakamura, Yutaro; Kaida, Yusuke; Fujisawa, Tomoyuki; Imokawa, Shiro; Yasuda, Kazumasa; Hashizume, Hideo; Yokomura, Koushi; Toyoshima, Mikio; Koshimizu, Naoki; Suganuma, Hideki; Shirai, Toshihiro; Dai, Huaping; Inui, Naoki; Colby, Thomas V.; Chida, Kingo

doi:10.1016/j.rmed.2010.04.022

Cited by 52 publications

(47 citation statements)

References 18 publications

(5 reference statements)

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“…Our symptoms criteria for AIF-ILD are very similar to those published by Kinder et al 5 and Suda et al 31 Our serologic panel additionally includes diseasespecifi c antibodies ( Table 1 ). We excluded the nonspecifi c erythrocyte sedimentation rate and C-reactive protein.…”

Section: Discussionmentioning

confidence: 83%

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Autoimmune-Featured Interstitial Lung Disease

Vij

Noth

Strek

2011

Chest

241

232

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Section: Discussionmentioning

confidence: 83%

“…31 In that study, patients with UCTD-NSIP had improved survival compared with those with idiopathic NSIP. Data were collected retrospectively, and the authors acknowledged selection and recall biases.…”

Section: Discussionmentioning

confidence: 86%

Autoimmune-Featured Interstitial Lung Disease

Vij

Noth

Strek

2011

Chest

241

232

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“…Comparison of survival curves during the course of 5 years showed that patients with UCTD-NSIP had a higher survival rate (100%) compared with idiopathic NSIP patients (58%). 25 Nonspecific interstitial pneumonia was the most common pattern identified on HRCT (57.1%) and on surgical lung biopsy (55%) in a retrospective cohort study of 56 patients who fulfilled classification criteria for IPAF. Most patients (98%) were treated with prednisone and/or immunosuppressive therapy.…”

Section: Characterization and Impact Of Morphologic Patterns In Ipaf mentioning

confidence: 96%

“…In this study, among 18 patients classified as UCTD who underwent surgical pulmonary biopsy, 15 showed an NSIP pattern, in contrast to only 2 patients in the control group that was categorized as idiopathic interstitial pneumonia. 10 In addition, a study by Suda et al 25 showed different prognoses in patients with NSIP associated with UCTD and patients with NSIP without criteria for UCTD. In their study, among 47 patients diagnosed with idiopathic NSIP who did not meet the criteria for a specific CTD, 22 had diagnostic parameters for UCTD.…”

Section: Characterization and Impact Of Morphologic Patterns In Ipaf mentioning

confidence: 99%

Morphologic Aspects of Interstitial Pneumonia With Autoimmune Features

Nascimento

Baldi

Sawamura

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Interstitial lung disease, a common complication observed in several connective tissue diseases, causes significant morbidity and mortality. Similar to individuals with connective tissue diseases, a significant subgroup of patients with clinical and serologic characteristics suggestive of autoimmunity but without confirmed specific connective tissue disease presents with associated interstitial lung disease. These patients have been classified using different controversial nomenclatures, such as undifferentiated connective tissue disease–associated interstitial lung disease, lung-dominant connective tissue disease, and autoimmune featured interstitial lung disease. The need for a better understanding and standardization of this entity, interstitial lung disease with autoimmune features, and the need for an adequate management protocol for patients resulted in the introduction of a new terminology in 2015: interstitial pneumonia with autoimmune features. This new classification requires a better comprehension of its diagnostic impact and the influence of its morphologic aspects on the prognosis of patients. Objective.— To review the diagnostic criteria for interstitial pneumonia with autoimmune features, with an emphasis on morphologic aspects. Data Sources.— The review is based on the available literature, and on pathologic, radiologic, and clinical experience. Conclusions.— The interstitial pneumonia with autoimmune features classification seems to identify a distinct subgroup of patients with different prognoses. Studies show that nonspecific interstitial pneumonia and usual interstitial pneumonia are the most prevalent morphologic patterns and show discrepant results on the impact of the usual interstitial pneumonia pattern on survival. Prospective investigations are necessary to better define this subgroup and to determine the prognosis and appropriate clinical management of these patients.

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“…IIP, die kein UIP-Muster aufweisen, sowie undifferenzierte Kollagenosen mit NSIPMuster weisen eine bessere Prognose als eine IPF auf [39]. Die systemische Sklerose und speziell die RA können neben einem NSIP-Muster auch mit einem radiologischen bzw.…”

Section: Prognose Von Nicht-ipf-fibrosierungen Und Ihren Exazerbationenunclassified

Acute on chronic respiratory failure in interstitial pneumonias

Westhoff

2014

Med Klin Intensivmed Notfmed

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Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD)

Cited by 52 publications

References 18 publications

Autoimmune-Featured Interstitial Lung Disease

Autoimmune-Featured Interstitial Lung Disease

Morphologic Aspects of Interstitial Pneumonia With Autoimmune Features

Acute on chronic respiratory failure in interstitial pneumonias

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