Autoimmune-Featured Interstitial Lung Disease

Vij, Rekha; Noth, Imre; Strek, Mary E.

doi:10.1378/chest.10-2662

Cited by 241 publications

(277 citation statements)

References 30 publications

Supporting

Mentioning

232

Contrasting

Unclassified

Order By: Relevance

“…Specifically, it is unclear whether results from a study using any one of the previously published criteria [19][20][21] is comparable to other studies using a different set of criteria. With IPAF, uniform terminology and classification criteria for related but potentially distinct entities (UCTD-ILD, lung-dominant CTD and autoimmune-featured ILD) have been systematically developed and ratified.…”

Section: Discussionmentioning

confidence: 99%

“…Previously published terms describing this patient group, including broad and strict forms of UCTD-ILD, lung-dominant CTD and autoimmune-featured ILD [19][20][21], should be abandoned and replaced with consensus-derived nomenclature.…”

Section: Methods and Processmentioning

confidence: 99%

“…A number of recent studies have shown that many patients diagnosed with an IIP have certain, often subtle, clinical features that suggest an underlying autoimmune process and yet do not meet established diagnostic criteria for any characterisable CTD [19][20][21][22]. In some patients, these features may occur in the absence of serologic abnormalities, while in others, a highly specific serum autoantibody may be present without typical systemic or extrathoracic findings.…”

Section: Introductionmentioning

confidence: 99%

“…Researchers around the world have proposed differing, but overlapping, criteria and terms to describe these patients, including "undifferentiated CTD associated ILD" (UCTD-ILD) [19], "lung-dominant CTD" [20] or "autoimmune-featured ILD" [21]. Each term is controversial, none has been universally accepted, and because of their subtly different diagnostic criteria, each would include many of, but not all, the same patients.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features

et al. 2015

Self Cite

View full text Add to dashboard Cite

Many patients with an idiopathic interstitial pneumonia (IIP) have clinical features that suggest an underlying autoimmune process but do not meet established criteria for a connective tissue disease (CTD). Researchers have proposed differing criteria and terms to describe these patients, and lack of consensus over nomenclature and classification limits the ability to conduct prospective studies of a uniform cohort.The "European Respiratory Society/American Thoracic Society Task Force on Undifferentiated Forms of Connective Tissue Disease-associated Interstitial Lung Disease" was formed to create consensus regarding the nomenclature and classification criteria for patients with IIP and features of autoimmunity.The task force proposes the term "interstitial pneumonia with autoimmune features" (IPAF) and offers classification criteria organised around the presence of a combination of features from three domains: a clinical domain consisting of specific extra-thoracic features, a serologic domain consisting of specific autoantibodies, and a morphologic domain consisting of specific chest imaging, histopathologic or pulmonary physiologic features.A designation of IPAF should be used to identify individuals with IIP and features suggestive of, but not definitive for, a CTD. With IPAF, a sound platform has been provided from which to launch the requisite future research investigations of a more uniform cohort. @ERSpublications ERS/ATS task force provides nomenclature and classification criteria for patients with IIP and autoimmune features

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methods and Processmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Circulating low-level autoantibodies have been reported in patients with IPF who lack clinical findings of CTD. An abnormal ANA is present in 25%-41% of IPF patients at a titre 1:40, and an elevated RF present in 6%-7%; [26][27][28] however, the significance of these autoantibodies is unclear given the similar frequencies seen in healthy age-matched control populations and the similar prognosis of serology-positive and serologynegative patients with IPF. [26][27][28] The mere presence of an autoantibody is therefore insufficient to provide a CTD-ILD diagnosis without additional confirmatory clinical data.…”

Section: High Resolution Computed Tomographymentioning

confidence: 99%