Distinct processing of social and monetary rewards in late adolescents with trait anhedonia.

Chan, Raymond C. K.; Li, Zhi; Li, Ke; Zeng, Yonghu; Xie, Weizhen; Yan, Chao; Cheung, Eric F.C.; Zhou, Jin

doi:10.1037/neu0000233

Cited by 51 publications

(43 citation statements)

References 30 publications

(62 reference statements)

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“…We found that interpersonal features were negatively correlated with social anticipatory pleasure, suggesting that participants with more interpersonal SP features experienced less anticipatory pleasure, especially in social‐related conditions. This is consistent with previous studies, which found that individuals with SP traits report diminished anticipatory pleasure (Li et al, ), and that people with social anhedonia anticipated less positive emotions in tasks containing more social information (Chan, Li, et al, ; Xie et al, ) and tasks including social conditions (Engel, Fritzsche, & Lincoln, ) than people without social anhedonia. This finding is corroborated by a recent network study, which reported that social anhedonia was one of the subdimensions of negative schizotypy (Christensen et al, ).…”

Section: Discussionsupporting

confidence: 92%

Network structure of anticipatory pleasure and risk features: Evidence from a large college sample

et al. 2019

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Investigating the relationship between anticipatory pleasure deficits and risk features of mental disorders not only theoretically benefits the understanding of anhedonia, but could also facilitate early detection and intervention of mental disorders. Using network analysis, the present study examined the pattern of relationship between anticipatory pleasure and risk features of schizophrenia spectrum, depressive, anxiety, autism spectrum, and obsessive-compulsive disorders in a large sample of college students (n = 2152). It was found that interpersonal features of schizotypal personality traits and poor social skills of autistic traits showed strong correlation with low social anticipatory pleasure. Depressive symptoms severity was weakly associated with reduced abstract anticipatory pleasure, while obsessive-compulsive traits were weakly associated with high contextual anticipatory pleasure. No significant correlation was found between anxiety symptoms severity and anticipatory pleasure.Social anticipatory pleasure had the highest strength centrality among all anticipatory pleasure components, while interpersonal features of schizotypal personality traits had the highest strength centrality in the whole network. Our findings suggest that impaired anticipatory pleasure, especially social anticipatory pleasure, is a particular feature of schizotypal personality traits and autistic traits. Our findings may have implications for intervention in that the social component may be a target to improve anhedonia in individuals with schizotypal and autistic traits, while interpersonal features may be a key treatment target given that it was central to the relationship between anticipatory pleasure and risk features.High incidence of comorbidity between diagnostic categories and heterogeneity in presentation within disorders (Kotov et al., 2017) suggest that discrete divisions between diagnostic categories may be less well-defined than previously assumed and evidence suggests that symptom expression is continuous between disorders (Lambert et al., 2018;

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Section: Discussionsupporting

confidence: 92%

Network structure of anticipatory pleasure and risk features: Evidence from a large college sample

et al. 2019

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“…For example, behavioral studies have shown performance impairments on tasks known to be supported by frontostriatal networks [Ettinger et al, ; O'Driscoll et al, ]. Studies using fMRI have shown more directly that schizotypy is associated with alterations in BOLD signal in striatum during task performance [Aichert et al, ; Chan et al, ; Ettinger et al, ; Li et al, ; Yan et al, ].…”

Section: Discussionmentioning

confidence: 99%

Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults

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Ettinger

Meindl³

et al. 2017

Human Brain Mapping

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Altered striatocortical functional connectivity has been suggested to be a trait marker of schizophrenia spectrum disorders, including schizotypal personality. In the present study, we examined the association between schizotypal personality traits and striatocortical functional connectivity in a sample of healthy adults. The German version of the Schizotypal Personality Questionnaire was obtained from N 5 111 participants recruited from the general public. Resting-state functional magnetic resonance imaging scans were acquired at 3T. Six striatal seed regions in each hemisphere were defined and striatocortical resting-state functional connectivity (rsFC) as well as its lateralization indices was calculated. Regression analysis showed that schizotypy scores, especially from the positive dimension, were positively correlated with rsFC between ventral striatum and frontal cortex and negatively associated with rsFC between dorsal striatum and posterior cingulate. No significant associations were found between negative dimension schizotypy and striatocortical rsFC. We also found positive correlations between schizotypy total scores and lateralization index of right dorsal caudate and right rostral putamen. In conclusion, the present study extends previous evidence of altered striatocortical rsFC in the schizophrenia spectrum. The observed associations resemble in part the alterations observed in psychotic patients and their relatives, providing support for dimensionality Additional Supporting Information may be found in the online version of this article.

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“…These three structures are known to be interconnected [33, 57, 63], and involved with processing visual information for emotional [50] and reward salience [11, 74]. Nucleus accumbens and amygdala are both involved with fear conditioning [52], and nucleus accumbens volume has been correlated with trait anxiety [39].…”

Section: Discussionmentioning

confidence: 99%

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

et al. 2016

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Mild traumatic brain injury (mTBI) is a significant health concern. The majority who sustain mTBI recover, although ~20 % continue to experience symptoms that can interfere with quality of life. Accordingly, there is a critical need to improve diagnosis, prognostic accuracy, and monitoring (recovery trajectory over time) of mTBI. Volumetric magnetic resonance imaging (MRI) has been successfully utilized to examine TBI. One promising improvement over standard volumetric approaches is to analyze high-dimensional shape characteristics of brain structures. In this study, subcortical shape and volume in 76 Service Members with mTBI was compared to 59 Service Members with orthopedic injury (OI) and 17 with post-traumatic stress disorder (PTSD) only. FreeSurfer was used to quantify structures from T1-weighted 3 T MRI data. Radial distance (RD) and Jacobian determinant (JD) were defined vertex-wise on parametric mesh-representations of subcortical structures. Linear regression was used to model associations between morphometry (volume and shape), TBI status, and time since injury (TSI) correcting for age, sex, intracranial volume, and level of education. Volumetric data was not significantly different between the groups. JD was significantly increased in the accumbens and caudate and significantly reduced in the thalamus of mTBI participants. Additional significant associations were noted between RD of the amygdala and TSI. Positive trendlevel associations between TSI and the amygdala and accumbens were observed, while a negative association was observed for third ventricle. Our findings may aid in the initial diagnosis of mTBI, provide biological targets for functional examination, and elucidate regions that may continue remodeling after injury.

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Distinct processing of social and monetary rewards in late adolescents with trait anhedonia.

Abstract: The results suggest that the AID and the MID tasks have unique activation patterns. Our findings also suggest that the AID task may be more sensitive in detecting anhedonia in people with trait anhedonia.

Cited by 51 publications

References 30 publications

Network structure of anticipatory pleasure and risk features: Evidence from a large college sample

Network structure of anticipatory pleasure and risk features: Evidence from a large college sample

Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

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