Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis

Afford, Simon C.; Fisher, Neil; Neil, Desley; Fear, Janine; Brun, P.; Hübscher, Stefan G.; Adams, David H.

doi:10.1002/(sici)1096-9896(199809)186:1<82::aid-path151>3.0.co;2-d

Cited by 132 publications

(95 citation statements)

References 37 publications

(39 reference statements)

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“…CCL3 and CCL5 are important chemokines of airway hyperresponsiveness; in contrast, the role of CCL4 in asthma is uncertain. However, there are some reports of higher levels of this cytokine in several pulmonary conditions, such as chronic bronchitis [9], pulmonary fibrosis [14], and cystic fibrosis [15].…”

Section: Discussionmentioning

confidence: 99%

“…CCL4 signals through CCR5 receptor, this receptor is expressed at high levels in Th1, and almost absent in Th2 cells. Levels of CCL4 are increased in alcoholic liver disease [9], glomerulonephritis, acute renal transplant rejection [10], human sepsis [11], and advanced atherosclerosis lesions [12]. There are no reports regarding the role of CCL4 in asthma disease but there are some observations of higher levels of this cytokine in several pulmonary conditions such as chronic bronchitis [13], pulmonary fibrosis [14], and cystic fibrosis [15].…”

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confidence: 99%

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CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

Velázquez¹,

Soid-Raggi²,

Terán³

et al. 2017

Health

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Aspirin-exacerbated respiratory disease (AERD) is an asthma phenotype characterized by nasal polyps, chronic hypertrophic eosinophilic sinusitis, asthma, and sensitivity to aspirin. Unawareness of this disease by patients and their physicians may have serious consequences because of the risk of near-fatal asthma. Its confirmative diagnosis can be established only by provocative aspirin challenge, which represents a potential risk for patient health. Purpose: Because CCL4 plays an important role in several pulmonary conditions, we tested its immunoreactivity in nasal lavages and sera from control subjects, and from aspirin-sensitive and non-aspirin-sensitive patients. Method: Immunoreactivity of CCL4 was measured in serum and nasal lavages from 30 healthy controls (HC), 23 patients with AERD, and 20 patients with aspirin-tolerant asthma (ATA). Additionally, a serum biobank contained sera from 90 HC, 83 patients with AERD, and 69 patients with ATA was employed. Results: The serum immunoreactivity of CCL4 could distinguish both types of asthma phenotypes. Conclusion: CCL4 may play an unexpected role in thephysiopathology of AERD.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

Velázquez¹,

Soid-Raggi²,

Terán³

et al. 2017

Health

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“…18 Ligands for CCR5, including MIP-1a and MIP-1b, are constitutively expressed on portal vessels, thus allowing recruitment of CCR5-positive lymphocytes to these areas as part of an immunosurveillance role. This expression may be enhanced during the development of inflammatory liver diseases such as chronic hepatitis C and alcoholic hepatitis, 18,48 and may also be increased in both acute and chronic liver allograft rejection. 49 The results of the current study suggest that the immunosurveillance role played by CCR5-positive lymphocytes may be compromised under special circumstances.…”

Section: Discussionmentioning

confidence: 99%

CCR5-Δ32 mutation is strongly associated with primary sclerosing cholangitis

et al. 2004

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“…Secretion of MCP1 may contribute to the formation and maintenance of the inflammatory infiltrate observed during chronic liver disease (Marra et al, 1998). Alcoholic hepatitis and alcoholic cirrhosis are associated with distinct patterns of chemokine expression that are likely to be important factors in determining whether a patient develops acute parenchymal inflammation and alcoholic hepatitis, or chronic septal inflammation and alcoholic cirrhosis (Afford et al, 1998).…”

Section: Association Of Common Promoter Polymorphisms Of Mcp1 With Hementioning

confidence: 99%

Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Park

Kim²,

Cheong³

et al. 2006

Exp Mol Med

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Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including angiotensinogen (AGT), cadherin 1 (CDH1), cyclooxygenase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n = 1,095) recruited from the Korean population. In addition, three polymorphisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis controlling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P = 0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.

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Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis

Cited by 132 publications

References 37 publications

CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

CCR5-Δ32 mutation is strongly associated with primary sclerosing cholangitis

Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

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