Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including angiotensinogen (AGT), cadherin 1 (CDH1), cyclooxygenase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n = 1,095) recruited from the Korean population. In addition, three polymorphisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis controlling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P = 0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.

CCND2 polymorphisms associated with clearance of HBV Infection

“…3 In addition to that, several previous studies have also reported associations between genetic polymorphisms and the risk of HCC and/or clearance of HBV. [3][4][5][6][7] D-type cyclins are the main integral mediators associating the extracellular signaling environment with cell-cycle progression. They are divided into three subtypes: cyclin D1, D2 and D3.…”

Association between RANTES -403A/G polymorphism and susceptibility to hepatitis B virus infection: A meta-analysis

“…All control individuals were in accordance with Hardy-Weinberg equilibrium. Two studies were of Caucasians [13,14]; the others were focused on Asians [11,12,[17][18][19][20]. However, two studies only presented the allelic data, our attempts of obtaining genotypic data from these two studies have failed.…”

“…Two of them were not performed in humans; seven studies were not focused on RANTES; four studies were vaccine related; eight were not casecontrol studies; one of them used the same dataset with a previous study; six studies did not analyze RANTES -403 polymorphism. According to our search strategy, eight case-control studies were eventually included in this meta-analysis [11][12][13][14][17][18][19][20]. Specific selection process is displayed in the flow chart in Figure 1.…”

RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population

“…Several studies have also verified the correlation of RANTES gene polymorphisms with HBV infection. These studies have invariably found a lack of association between the RANTES gene and HBV infection (Duan et al, 2005;Ahn et al, 2006;Park et al, 2006;Cheong et al, 2007;Thio et al, 2008). Despite the increased prevalence of HBV infections in Saudi Arabia, no information is available regarding RANTES gene polymorphisms and their relationships with viral susceptibility and disease progression.…”

“…The clinical course of HBV infection varies from spontaneous recovery after acute hepatitis to a chronic persistent infection that may progress to cirrhosis or HCC. The mechanisms underlying resolution of acute HBV infection or its progression to chronicity are not clearly understood but are suggested to depend on host immune response and genetic factors (Grakoui et al, 2003;Bowen and Walker, 2005;Park et al, 2006;Durantel and Zoulim, 2009).…”