Distinct microRNA expression in endometrial lymphocytes, endometrium, and trophoblast during spontaneous porcine fetal loss

Bidarimath, Mallikarjun; Edwards, Andrew K.; Wessels, Jocelyn M.; Khalaj, Kasra; Kridli, Rami T.; Tayade, Chandrakant

doi:10.1016/j.jri.2014.11.004

Cited by 23 publications

(25 citation statements)

References 56 publications

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“…Associated X Protein (BAX) and nuclear factor of kappa light polypeptide gene enhancer in Bcells (NfκB) apoptotic mechanisms are dysregulated during peri-attachment at the maternal side of the M-F interface in arresting CAS [62]. We also observed the TNF family members Fas cell 230 surface death receptor (Fas) and its ligand (FasL) to be significantly up-regulated at gd21 on the maternal side in arresting CAS [17].…”

Section: Cytokines and Their Regulation At The Porcine Maternal-fetalmentioning

confidence: 80%

“…Anti-angiogenic factor [62,106] ↑ in endometrium from arresting CAS DND in endometrium or CAM from healthy & arresting CAS…”

Section: Plgfmentioning

confidence: 99%

“…Connective tissue growth factor [62] ↑ in endometrium from arresting CAS DND DARC Duffy antigen receptor for chemokines [56] DND ↓ in endometrium from arresting CAS…”

Section: Plgfmentioning

confidence: 99%

“…In order to acquire a better understanding of the underlying physiological causes affecting spontaneous porcine conceptus mortality, our laboratory investigated changes encountered by healthy and arresting CAS at specific gestational time points accounting for early and midgestation fetal losses [17]. In much of our research, we addressed disparity between healthy and M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 18 abortive CAS during the peri-attachment (gd20) and mid-gestational (gd50) periods [18,53,56,60,62,79,80] to reflect the two major waves of conceptus loss in pigs. Our model is based on visual and arithmetic distinction between healthy and arresting conceptuses at both gd20 and 50 ( Figure 1).…”

mentioning

confidence: 99%

“…Additionally, through LCM, we are also able to understand some of the roles that immune cells play in 395 angiogenesis during pregnancy [17,18,55,62].…”

mentioning

confidence: 99%

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Placentation, maternal–fetal interface, and conceptus loss in swine

et al. 2016

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Section: Cytokines and Their Regulation At The Porcine Maternal-fetalmentioning

confidence: 80%

“…Anti-angiogenic factor [62,106] ↑ in endometrium from arresting CAS DND in endometrium or CAM from healthy & arresting CAS…”

Section: Plgfmentioning

confidence: 99%

“…Connective tissue growth factor [62] ↑ in endometrium from arresting CAS DND DARC Duffy antigen receptor for chemokines [56] DND ↓ in endometrium from arresting CAS…”

Section: Plgfmentioning

confidence: 99%

mentioning

confidence: 99%

“…Additionally, through LCM, we are also able to understand some of the roles that immune cells play in 395 angiogenesis during pregnancy [17,18,55,62].…”

mentioning

confidence: 99%

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Placentation, maternal–fetal interface, and conceptus loss in swine

et al. 2016

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Maternal lactocrine programming of porcine reproductive tract development

Bagnell

George

et al. 2017

Molecular Reproduction Devel

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The lactocrine hypothesis for maternal programming of female reproductive tract development is based on the idea that non-nutritive, milk-borne bioactive factors (MbFs), delivered from mother to offspring during nursing, play a role in determining the trajectory of development with long-term consequences in the adult. Porcine female reproductive tract development is completed postnatally, and the period during which maternal support of neonatal growth derives exclusively from colostrum/milk defines a window of opportunity for lactocrine programming of reproductive tissues. Beyond nutrition, milk serves as a delivery system for a variety of bioactive factors. Porcine relaxin is a prototypical MbF. Present in colostrum at highest concentrations at birth, relaxin is transmitted into the circulation of nursing piglets where it can act on Relaxin receptors found in neonatal female reproductive tract tissues. This process is facilitated by the physiology of the maternal-neonatal dyad and the fact that the neonatal gastrointestinal tract is open to absorb macromolecules for a period of time postnatally. Age at first nursing and duration of nursing from birth are also important for porcine female reproductive tract development. These parameters affect both the quality and quantity of colostrum consumed. Disruption of lactocrine signaling by feeding milk replacer from birth altered porcine uterine, cervical, and testicular development by postnatal Day 2. Moreover, insufficient colostrum consumption in nursing piglets can impair uterine capacity to support viable litters of optimal size in adulthood. In the pig, lactocrine signaling supports neonatal organizational events associated with normal reproductive development and may program adult uterine capacity.

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MicroRNA regulation of immune events at conception

Robertson

Zhang

Chan

et al. 2017

Molecular Reproduction Devel

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The reproductive tract environment at conception programs the developmental trajectory of the embryo, sets the course of pregnancy, and impacts offspring phenotype and health. Despite the fundamental importance of this stage of reproduction, the rate-limiting regulatory mechanisms operating locally to control fertility and fecundity are incompletely understood. Emerging studies highlight roles for microRNAs (miRNAs) in regulating reproductive and developmental processes and in modulating the quality and strength of the female immune response. Since endometrial receptivity and robust placentation require specific adaptation of the immune response, we hypothesize that miRNAs participate in establishing pregnancy through effects on key gene networks in immune cells. Our recent studies investigated miRNAs that are induced in the peri-conception environment, focusing on miRNAs that have immune-regulatory roles-particularly miR-223, miR-155, and miR-146a. Genetic mouse models deficient in individual miRNAs are proving informative in defining roles for these miRNAs in the generation and stabilization of regulatory T cells (Treg cells) that confer adaptive immune tolerance. Overlapping and redundant functions between miRNAs that target multiple genes, combined with multiple miRNAs targeting individual genes, indicate complex and sensitive regulatory networks. Although to date most data on miRNA regulation of reproductive events are from mice, conserved functions of miRNAs across species imply similar biological pathways operate in all mammals. Understanding the regulation and roles of miRNAs in the peri-conception immune response will advance our knowledge of how environmental determinants act at conception, and could have practical applications for animal breeding as well as human fertility.

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Distinct microRNA expression in endometrial lymphocytes, endometrium, and trophoblast during spontaneous porcine fetal loss

Cited by 23 publications

References 56 publications

Placentation, maternal–fetal interface, and conceptus loss in swine

Placentation, maternal–fetal interface, and conceptus loss in swine

Maternal lactocrine programming of porcine reproductive tract development

MicroRNA regulation of immune events at conception

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