Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis

Zella, Garrett C.; Hait, Elizabeth J.; Glavan, Tiffany; Gevers, Dirk; Ward, Doyle V.; Kitts, Christopher L.; Korzenik, Joshua R.

doi:10.1002/ibd.21460

Cited by 73 publications

(60 citation statements)

References 44 publications

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“…242 The other study analyzed the FAM and MAM of UC patients with and without pouchitis compared with Familial Adenomatous Polyposis pouches and found that UC pouchitis patients had substantially fewer Bacteroidetes and more Clostridia compared to the healthy UC pouch and Familial Adenomatous Polyposis groups. 243 …”

Section: Pouchitismentioning

confidence: 97%

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Cruz

Prideaux

Wagner

et al. 2012

Inflammatory Bowel Diseases

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The enteric bacterial flora play a key role in maintaining health. Inflammatory bowel disease is associated with quantitative and qualitative alterations in the microbiota. Early characterization of the microbiota involved culture-dependent techniques. The advent of metagenomic techniques, however, allows for structural and functional characterization using culture-independent methods. Changes in diversity, together with quantitative alterations in specific bacterial species, have been identified. The functional significance of these changes, and their pathogenic role, remain to be elucidated.

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Section: Pouchitismentioning

confidence: 97%

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Cruz

Prideaux

Wagner

et al. 2012

Inflammatory Bowel Diseases

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“…Although created from small intestinal tissue, the microbiota of the pouch frequently resembles that of the colon. 122 Like UC itself, however, patients with pouchitis may have a pouch microbiota that is distinct from that of patients without active inflammation. 122,123 Although this suggests that FMT may also be a treatment of pouchitis, small studies have failed to demonstrate remission following FMT.…”

Section: Pouchitismentioning

confidence: 99%

“…122 Like UC itself, however, patients with pouchitis may have a pouch microbiota that is distinct from that of patients without active inflammation. 122,123 Although this suggests that FMT may also be a treatment of pouchitis, small studies have failed to demonstrate remission following FMT. 124 One key limitation in FMT for pouchitis is the size of the pouch, which may limit engraftment of a donor microbiota.…”

Section: Pouchitismentioning

confidence: 99%

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

2017

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Inflammatory bowel disease (IBD) is a complex set of diseases that lead to chronic inflammation in the gastrointestinal tract. Although the etiology of IBD is not fully understood, it is well-known that the intestinal microbiota is associated with the development and maintenance of IBD. Manipulation of the gut microbiota, therefore, may represent a target for IBD therapy. Fecal microbiota transplantation (FMT), where fecal microbiota from a healthy donor is transplanted into a patient's GI tract, is already a successful therapy for Clostridium difficile infection. FMT is currently being explored as a potential therapy for IBD as well. In this review, the associations between the gut microbiota and IBD and the emerging data on FMT for IBD will be discussed.

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“…Only now, with the increasing number of animal microbiome data available, are we beginning to understand the nature of microbiome plasticity in animals [85,170]. With recent studies on the relative contributions of factors such as host genetics [128,170], diet [171], environmental exposure [87] and health [172], we are now poised to venture toward a quantified understanding of microbiome evolution. It is clear that a multifaceted approach is the only way we can hope to understand how a microbiome evolves and adapts along inter-and intra-specific axes, along with the varying contributions of polygenic traits on the abundance and interactions of individual microbial species, related taxa, and groups of distantly related organisms.…”

Section: Perspectivementioning

confidence: 99%

Towards an Evolutionary Model of Animal-Associated Microbiomes

Yeoman

Chia

Yıldırım

et al. 2011

Entropy

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Second-generation sequencing technologies have granted us greater access to the diversity and genetics of microbial communities that naturally reside endo-and ecto-symbiotically with animal hosts. Substantial research has emerged describing the diversity and broader trends that exist within and between host species and their associated microbial ecosystems, yet the application of these data to our evolutionary understanding of microbiomes appears fragmented. For the most part biological perspectives are based on limited observations of oversimplified communities, while mathematical and/or computational modeling of these concepts often lack biological precedence. In recognition of this disconnect, both fields have attempted to incorporate ecological theories, although their applicability is currently a subject of debate because most ecological theories were developed based on observations of macro-organisms and their ecosystems. For the OPEN ACCESSEntropy 2011, 13 571 purposes of this review, we attempt to transcend the biological, ecological and computational realms, drawing on extensive literature, to forge a useful framework that can, at a minimum be built upon, but ideally will shape the hypotheses of each field as they move forward. In evaluating the top-down selection pressures that are exerted on a microbiome we find cause to warrant reconsideration of the much-maligned theory of multi-level selection and reason that complexity must be underscored by modularity.

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Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis

Abstract: The pouch microbial environment appears to be distinctly different in the settings of UC pouchitis, healthy UC, and FAP. These findings suggest that a dysbiosis may exist in pouchitis which may be central to understanding the disease.

Cited by 73 publications

References 44 publications

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Towards an Evolutionary Model of Animal-Associated Microbiomes

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