2010
DOI: 10.1002/jbm.a.32813
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Distinct immunohistomorphologic changes in periprosthetic hip tissues from historical and highly crosslinked UHMWPE implant retrievals

Abstract: Assessment of immune response to implant wear debris in periprosthetic tissue following total hip arthroplasty suggests that multiple factors are involved in the loss implant function. The current study investigated wear debris and the associated immunohistomorphologic changes in tissues from nine patients with historical (gamma air-sterilized) and nine highly-crosslinked UHMWPE implant components. Paraffin embedded tissue sections were evaluated for the presence of histiocytes, giant cells, fibrocartilage/bon… Show more

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Cited by 16 publications
(23 citation statements)
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“…We recently reported the presence of histomorphologic changes in HXLPE revision tissues [8]. Specifically, our results showed a prevalence of fibrocartilage in tissues from HXLPE revisions implanted for less than 3 years (four of nine patients), implicating poor osseointegration in the development of loosening [71].…”
Section: Adaptive Immune Response Includes Several Subgroups Of T Lymmentioning
confidence: 53%
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“…We recently reported the presence of histomorphologic changes in HXLPE revision tissues [8]. Specifically, our results showed a prevalence of fibrocartilage in tissues from HXLPE revisions implanted for less than 3 years (four of nine patients), implicating poor osseointegration in the development of loosening [71].…”
Section: Adaptive Immune Response Includes Several Subgroups Of T Lymmentioning
confidence: 53%
“…We collected tissue samples from 18 consenting patients undergoing revision THA of uncemented, metal-on-UHMWPE hip components using a standardized tissue retrieval protocol; these are the same tissues used in the previous study [8]. UHMWPE liners were classified into two cohorts: conventional gamma air-sterilized UHMWPE (n = 9) and gamma inert-sterilized HXLPE (n = 9).…”
Section: Methodsmentioning
confidence: 99%
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