Distinct genetic forms of frontotemporal dementia

Abstract

Future genetic studies need to identify genetic defects in at least two distinct familial forms of frontotemporal dementia (FTD) with unknown genetic defects: frontotemporal lobe degeneration with ubiquitin-positive inclusions with hippocampal sclerosis and frontotemporal lobe degeneration with motor neuron disease.

Manifestaciones neuropsiquiátricas y cognitivas en demencia frontotemporal y esclerosis lateral amiotrófica: dos polos de una entidad común

“…La exacta relación entre genes y hallazgos patológicos todavía no está clara. Una historia familiar prominente se observa en alrededor de 5-10% de los pacientes con ELA 5 y en 10-27% de pacientes con DFT 124 . Los genes relacionados con DFT y ELA se describen en la Tabla 4.…”

Frontotemporal Lobar Degeneration

“…30-50 % of patients with bvFTLD have a positive family history. Patients presenting clinically with SD or PNFA show a lower frequency (Seelaar, Kamphorst et al 2008;Chow, Miller et al 1999; (Stevens, van Duijn et al 1998;Rohrer, Guerreiro et al 2009 …”

The topography of cortical microbleeds in frontotemporal lobar degeneration: a post-mortem 7.0-tesla magnetic resonance study

“…FTLD is the second most common cause of presenile dementia with different genetic subtypes [20]. Despite the fact that most cases have a presenile onset, FTLD is not rare amongst elderly patients [3].…”