Distinct gene expression in human Vδ1 and Vδ2 γδ T cells following non-TCR agonist stimulation

Kress, Ellen; Hedges, Jodi F.; Jutila, Mark A.

doi:10.1016/j.molimm.2005.11.011

Cited by 51 publications

(59 citation statements)

References 43 publications

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“…In addition, we provide evidence that peripheral blood Vδ1TCR + T cells from tolerant liver recipients exhibit unique expression and cell-surface traits that distinguish them from those present in either nontolerant recipients or nontransplanted healthy individuals. Vδ1TCR + T cells have been reported to exert immunoregulatory functions in a variety of nontransplantation experimental and clinical settings (14)(15)(16)(17)(18)(19). In liver transplantation, further studies are needed to dissect the functional properties of Vδ1TCR + T cells and to determine whether these cells have direct suppressive abilities on alloaggressive lymphocytes or act by pro- ducing growth factors and repairing tissue damage, as has been shown for the intestinal mucosa (18,(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients

Martínez‐Llordella

Lozano²,

Puig-Pey³

et al. 2008

J. Clin. Invest.

187

253

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A fraction of liver transplant recipients are able to discontinue all immunosuppressive therapies without rejecting their grafts and are said to be operationally tolerant to the transplant. However, accurate identification of these recipients remains a challenge. To design a clinically applicable molecular test of operational tolerance in liver transplantation, we studied transcriptional patterns in the peripheral blood of 80 liver transplant recipients and 16 nontransplanted healthy individuals by employing oligonucleotide microarrays and quantitative real-time PCR. This resulted in the discovery and validation of several gene signatures comprising a modest number of genes capable of identifying tolerant and nontolerant recipients with high accuracy. Multiple peripheral blood lymphocyte subsets contributed to the tolerance-associated transcriptional patterns, although NK and γδTCR + T cells exerted the predominant influence. These data suggest that transcriptional profiling of peripheral blood can be employed to identify liver transplant recipients who can discontinue immunosuppressive therapy and that innate immune cells are likely to play a major role in the maintenance of operational tolerance in liver transplantation.

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Section: Discussionmentioning

confidence: 99%

Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients

Martínez‐Llordella

Lozano²,

Puig-Pey³

et al. 2008

J. Clin. Invest.

187

253

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“…However, Vd1 and Vd2 cells differ functionally from one another when cytokine release and expression profiles of homing receptors are considered. Vd2 cells tend to express more genes involved in promoting inflammation, but Vd1 cells express higher levels of regulatory genes (33,34). Accumulated evidence suggests that the regulatory function exists in the gd T cell population.…”

Section: Discussionmentioning

confidence: 99%

Generation of Human Regulatory γδ T Cells by TCRγδ Stimulation in the Presence of TGF-β and Their Involvement in the Pathogenesis of Systemic Lupus Erythematosus

Kang

Zhang

et al. 2011

The Journal of Immunology

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As a component of the innate immune cell population, γδ T cells are involved in tumor immunosurveillance and host defense against viral invasion. In this study, we demonstrated a novel function of human γδ T cells as regulatory cells by detecting their suppressive effect on the proliferation of autologous naive CD4+ T cells. These regulatory γδ T cells (γδ Tregs) could be generated in vitro by stimulating with anti-TCRγδ in the presence of TGF-β and IL-2. Similar to CD4+Foxp3+ Tregs, γδ Tregs also expressed Foxp3. Additionally, they primarily belonged to the Vδ1 subset with a CD27+CD25high phenotype. Furthermore, these γδ Tregs showed an immunoregulatory activity mainly through cell-to-cell contact. Importantly, this γδ regulatory population decreased in the peripheral blood of systemic lupus erythematosus patients, suggesting a potential mechanism in understanding the pathogenesis of systemic lupus erythematosus.

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“…Frequently, a cellular function is associated with the secretion of a characteristic cytokine pattern. For human, murine, and bovine ␥␦ T-cell subpopulations, the ability to produce different cytokines has already been demonstrated (6,24,29). Especially in infectious processes, however, the cytokine transcription rates or the characteristic cytokine panel may change and, in this way, define the specific functional capacity of a unique cell subset.…”

Section: Discussionmentioning

confidence: 99%

“…Especially in infectious processes, however, the cytokine transcription rates or the characteristic cytokine panel may change and, in this way, define the specific functional capacity of a unique cell subset. Consequently, the cytokine or chemokine secretion level has been utilized to characterize ␥␦ T-cell subsets after stimulation (23,25,26,29). For example, human V␦1 ϩ T cells were triggered to produce IFN-␥ after activation with Gram-negative bacterial products (14).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Avian γδ T-Cell Subsets afterSalmonella entericaSerovar Typhimurium Infection of Chicks

2011

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Distinct gene expression in human Vδ1 and Vδ2 γδ T cells following non-TCR agonist stimulation

Cited by 51 publications

References 43 publications

Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients

Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients

Generation of Human Regulatory γδ T Cells by TCRγδ Stimulation in the Presence of TGF-β and Their Involvement in the Pathogenesis of Systemic Lupus Erythematosus

Characterization of Avian γδ T-Cell Subsets afterSalmonella entericaSerovar Typhimurium Infection of Chicks

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