Distinct effects of nociceptin analogs on scopolamine-induced memory impairment in mice

Miwa, Masaya; Shinki, Chieko; Uchida, Shogo; Hiramatsu, Masayuki

doi:10.1016/j.ejphar.2008.11.027

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…If its spatial working memory is intact an animal is supposed to alternate regularly between the three arms in order to optimize its exploration strategy. (Hiramatsu and Inoue 1999;Mamiya et al 1999;Miwa et al 2009;Ouagazzal 2015)…”

Section: Conclusion -Future Directionsmentioning

confidence: 99%

“…Some studies have shown that very low doses of icv N/OFQ (10-100 fmol) could prevent the deleterious action of scopolamine in models of working memory (spontaneous alternation in Y-maze) and IA (Hiramatsu and Inoue 2000). Such promnesic effects have even been reported for doses as low as 1 fmol after intra-HPC injection (Miwa et al 2009). However, it has since been shown that these properties were not mediated by the NOP receptor as they persisted in receptor KO mice, and the involvement of a metabolite of the peptide has been suggested (Miwa et al 2010).…”

Section: Promnesic Effects Of Nop Agonistsmentioning

confidence: 99%

“…If it remembers receiving the electric shock the step-through or step-down latency should increase. (Adem et al 2017;Hiramatsu and Inoue 1999;Hiramatsu et al 2008;Liu et al 2007;Manabe et al 1998;Miwa et al 2009;Miwa et al 2010;Roozendaal et al 2007) Object Recognition (OR)…”

Section: Conclusion -Future Directionsmentioning

confidence: 99%

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The Nociceptin/Orphanin FQ System and the Regulation of Memory

Moulédous

2018

Handbook of Experimental Pharmacology

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Nociceptin/Orphanin FQ (N/OFQ) is an endogenous neuropeptide of 17 amino acids, related to opioid peptides but with its own receptor, distinct from conventional opioid receptors, the ORL1 or NOP receptor. The NOP receptor is a G protein-coupled receptor which activates Gi/o proteins and thus induces an inhibition of neuronal activity. The peptide and its receptor are widely expressed in the central nervous system with a high density of receptors in regions involved in learning and memory. This review describes the consequences of the pharmacological manipulation of the N/OFQ system by NOP receptor ligands on learning processes and on the consolidation of various types of long term memory. We also discuss the role of endogenous N/OFQ release in the modulation of learning and memory. Finally we propose several putative neuronal mechanisms taking place at the level of the hippocampus and amygdala and possibly underlying the behavioral amnestic or promnesic effects of NOP ligands.

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Section: Conclusion -Future Directionsmentioning

confidence: 99%