Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide (NOP) receptor-independent mechanism

Miwa, Masaya; Uchida, Shogo; Horiba, Fumika; Takeshima, Hiroshi; Nabeshima, Toshitaka; Hiramatsu, Masayuki

doi:10.1016/j.nlm.2009.12.006

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…350 At a very low dose (10 fmol), nociceptin attenuates pharmacologically induced memory impairment. 351 An inhibitory effect has also been observed with a nociceptin receptor agonist, Ro 64-6198. 345,352 Impairment of learning and memory have been also observed in other behavioral tests, such as the Y maze and the step-down passive avoidance test, with doses of 1.5-5 nmol.…”

Section: Miscellaneous Peptidesmentioning

confidence: 95%

“…When injected into the CA3 region, nociceptin dramatically impairs spatial learning in the Morris water maze at high doses (10 nmol/animal) but improves it at lower doses (1 nmol) . At a very low dose (10 fmol), nociceptin attenuates pharmacologically induced memory impairment . An inhibitory effect has also been observed with a nociceptin receptor agonist, Ro 64‐6198 .…”

Section: Other Peptidesmentioning

confidence: 98%

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Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck

Pourié

2013

Nutr Rev

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The hippocampus is a brain region of primary importance for neurogenesis, which occurs during early developmental states as well as during adulthood. Increases in neuronal proliferation and in neuronal death with age have been associated with drastic changes in memory and learning. Numerous neurotransmitters are involved in these processes, and some neuropeptides that mediate neurogenesis also modulate feeding behavior. Concomitantly, feeding peptides, which act primarily in the hypothalamus, are also present in the hippocampus. This review aims to ascertain the role of several important feeding peptides in cognitive functions, either through their local synthesis in the hippocampus or through their actions via specific receptors in the hippocampus. A link between neurogenesis and the orexigenic or anorexigenic properties of feeding peptides is discussed.

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Section: Miscellaneous Peptidesmentioning

confidence: 95%

Section: Other Peptidesmentioning

confidence: 98%

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck

Pourié

2013

Nutr Rev

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“…Such promnesic effects have even been reported for doses as low as 1 fmol after intra-HPC injection (Miwa et al 2009). However, it has since been shown that these properties were not mediated by the NOP receptor as they persisted in receptor KO mice, and the involvement of a metabolite of the peptide has been suggested (Miwa et al 2010).…”

Section: Promnesic Effects Of Nop Agonistsmentioning

confidence: 99%

“…If it remembers receiving the electric shock the step-through or step-down latency should increase. (Adem et al 2017;Hiramatsu and Inoue 1999;Hiramatsu et al 2008;Liu et al 2007;Manabe et al 1998;Miwa et al 2009;Miwa et al 2010;Roozendaal et al 2007) Object Recognition (OR)…”

Section: Conclusion -Future Directionsmentioning

confidence: 99%

The Nociceptin/Orphanin FQ System and the Regulation of Memory

Moulédous

2018

Handbook of Experimental Pharmacology

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Nociceptin/Orphanin FQ (N/OFQ) is an endogenous neuropeptide of 17 amino acids, related to opioid peptides but with its own receptor, distinct from conventional opioid receptors, the ORL1 or NOP receptor. The NOP receptor is a G protein-coupled receptor which activates Gi/o proteins and thus induces an inhibition of neuronal activity. The peptide and its receptor are widely expressed in the central nervous system with a high density of receptors in regions involved in learning and memory. This review describes the consequences of the pharmacological manipulation of the N/OFQ system by NOP receptor ligands on learning processes and on the consolidation of various types of long term memory. We also discuss the role of endogenous N/OFQ release in the modulation of learning and memory. Finally we propose several putative neuronal mechanisms taking place at the level of the hippocampus and amygdala and possibly underlying the behavioral amnestic or promnesic effects of NOP ligands.

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Nociceptin/Orphanin-FQ Modulation of Learning and Memory

Ouagazzal

2015

Nociceptin Opioid

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Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide (NOP) receptor-independent mechanism

Cited by 5 publications

References 47 publications

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

The Nociceptin/Orphanin FQ System and the Regulation of Memory

Nociceptin/Orphanin-FQ Modulation of Learning and Memory

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