Distant metastases in newly diagnosed tongue squamous cell carcinoma

Abstract

Objective To characterize the incidence and survivals of patients with distant metastases in newly diagnosed tongue squamous cell carcinoma. Materials and methods Patients with distant metastases in newly diagnosed tongue squamous cell carcinoma were collected from the Surveillance, Epidemiology, and End Results database. Data were classified by sex, age, race, insurance status, T stage, N stage and grade. Multivariable logistic and Cox regression were used to demonstrate risk factors of the presence of distant metastases and hazards related to mortality, respectively. Results We found 92 patients with distant metastases in newly diagnosed tongue squamous cell carcinoma, including lung, bone, liver, and brain, representing 1.08% of the entire cohort. 69 were male and 23 were female. Median survival among patients with distant metastases was 4.0 months. Conclusion The study describes the incidence and prognosis of patients with distant metastases in newly diagnosed tongue squamous cell carcinoma based on population estimates. The findings lend support to closely monitor the development of distant metastases among patients with predictors at the time of diagnosis of tongue squamous cell carcinoma.

The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells

“…TSCC is the most common oral cancer type, which is characterized by its strong lymph node and distant metastasis capability. 14 – 16 The incidence of the disease is rising in the population, particularly for women and/or young adults. 17 – 19 Despite the recent advances in the therapeutic management of TSCC by combinatory strategy involving surgery, radiation, and chemotherapy, the mortality of TSCC is still at a high level.…”

A case of tongue squamous cell carcinoma with multiple metastases to the gluteal region

“…Distant metastases of OSCC are uncommon but occur at many sites; 70% of distant metastases occur within 1 year after treatment of the primary tumor of OSCC, and their median overall survival is estimated at 4-10 months. 3,4 The most common distant metastatic site is the lung, followed by the bones and liver. [3][4][5] However, Takagi et al…”

“…3,4 The most common distant metastatic site is the lung, followed by the bones and liver. [3][4][5] However, Takagi et al…”

“…Furthermore, 5.3%-19.4% of patients with OSCC experience distant metastases after treatment. 3 Distant metastases of OSCC are common in the lungs and bones. Skin metastasis of OSCC usually occurs in the neck and near the primary site.…”

“…OSCC can metastasize to the cervical lymph nodes. Furthermore, 5.3%–19.4% of patients with OSCC experience distant metastases after treatment 3 . Distant metastases of OSCC are common in the lungs and bones.…”