Distance-of-Flight Mass Spectrometry: What, Why, and How?

Dennis, Elise A.; Gundlach‐Graham, Alexander; Ray, Steven J.; Enke, Christie G.; Hieftje, Gary M.

doi:10.1007/s13361-016-1458-1

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…A technique closely related to TOFMS, which is known as DOFMS, has recently been developed and has been reviewed elsewhere (Enke et al, 2012; Dennis et al, 2016a). In DOFMS, the m / z of an ion is measured based on the distance ( d ) the ion travels during a given time, where d α ( m / z ) −1 .…”

Section: Distance‐of‐flight Mass Spectrometry (Dofms)mentioning

confidence: 99%

Recent Advances in Instrumental Approaches to Time‐of‐flight Mass Spectrometry

Brais

Orejas

Schwartz

et al. 2020

Mass Spectrometry Reviews

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Time-of-flight mass spectrometry (TOFMS) is one of the simplest and most powerful approaches for mass spectrometry. Realization of the advantages inherent in TOFMS requires innovation in the theory and practice of the technique. Instrumental developments, in turn, create new capabilities that enable applications in chemical measurement. This review focuses on the recent advances in TOFMS instrumentation. New strategies for ion acceleration, multiplexed detection, miniaturized TOFMS instruments, approaches to extend the length of ion flight, and novel ion detection technologies are reviewed. Techniques that change the basic paradigm of TOFMS by measuring m/z based on ion flight distance are considered, as are applications at the frontiers of instrumental performance.

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Section: Distance‐of‐flight Mass Spectrometry (Dofms)mentioning

confidence: 99%

Recent Advances in Instrumental Approaches to Time‐of‐flight Mass Spectrometry

Brais

Orejas

Schwartz

et al. 2020

Mass Spectrometry Reviews

Self Cite

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“…Nowadays, many state‐of‐the‐art TOFMS apparatuses have been designed with the help of ion trajectory simulation software (eg, SIMION), which also well cope with the KED issues . Additionally, an up‐to‐date distance‐of‐flight mass spectrometer was also proposed for conquering the initial KED of ions to some extent . Last but not the least, a novel ion funnel interface was installed for conventional ICP‐MS with trouble‐shooting of high KED of ions and low transmission efficiency …”

Section: Introductionmentioning

confidence: 99%

“…[41][42][43][44] Additionally, an up-to-date distance-of-flight mass spectrometer was also proposed for conquering the initial KED of ions to some extent. [45][46][47][48] Last but not the least, a novel ion funnel interface was installed for conventional ICP-MS with trouble-shooting of high KED of ions and low transmission efficiency. 49 Suffering from the issues of the LI source aforementioned, several strategies on the modification of the conventional LI-TOFMS have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Improved detection sensitivity of elements in solids via laser postionization in laser desorption time‐of‐flight mass spectrometry

et al. 2018

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A newly constructed laser desorption (532 nm, 5 ns) and laser postionization (266 nm, 5 ns) time-of-flight mass spectrometer (LD-LPI-TOFMS) has been applied for improving the detection sensitivity of elements in solid samples. This method affords to acquire the information of the elemental impurities in solid standards as well as limit of detection (LOD) down to 10 g/g for some elements. Neutral atoms of solids are generated by low-irradiance laser desorption (< 10 W/cm ), followed by high-irradiance laser postionization (~ 10 W/cm ) of the desorbed atoms, facilitating to decouple the desorption and ionization processes in spatial and temporal domain. This non-interacting feature overcomes the discrimination between deteriorating spectral resolution at high irradiance (10 -10 W/cm ) and limited detectable elemental species and high LOD at low or medium irradiance (below 10 W/cm ). The utilization of originally "wasted" neutral atoms by laser postionization will help improve atom utilization and instrumental sensitivity. In this work, getting the utmost out of the consumed neutral atoms instead of an increment in sampling amounts is given attention with high priority for achieving high sensitivity and low LOD, which is especially useful on the occasions where very low sample consumption is desired.

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Atomic spectrometry update: review of advances in atomic spectrometry and related techniques

Evans

Pisonero

Smith

et al. 2018

J. Anal. At. Spectrom.

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SUMMARY OF CONTENTS This review covers developments in 'Atomic Spectrometry'. It covers atomic emission, absorption, fluorescence and mass spectrometry, but excludes material on speciation and coupled techniques which is included in a separate review. It should be read in conjunctionwith the other related reviews in the series. [1][2][3][4][5][6] Sample introductionThis section covers developments in sample introduction for all instrumental methods. LiquidsLiquid sample introduction relates to methods wherein the sample is introduced into the instrument in the form of a liquid, such as through nebulization or into a thermal vaporizer; whereas in vapour generation the sample is initially in the form of a liquid but is converted to a vapour prior to introduction into the instrument. Sample pre-treatment.A general review of on-line preconcentration for ICP-MS has been published by Das et al. 7 , covering solid phase methods and including 63 references. Several reviews of sample pretreatment methods used for atomic spectrometry are worth noting because they focus on specific areas: Kocurova et al. 8and Jain and Verma 9 have reviewed advances in DLLME (53 references) and SDME (407 references) respectively; Zhao et al. the same authors studied the stability of the labelled complexes at different pH and temperature, and when subject to separation using LC. They reported a significant decrease in stability when LC separation was used, and some degradation at 37 °C compared to 2 °C.Li et al. An immunoassay-linked method using gold nano-particles has been developed by Jarujamrus et al. 33 . In this approach the monoclonal antibody-chloramphenicol was attached to a solid support. Antigen-chloramphenicol was labelled with gold nano-particles (10 nm) at pH 9.5, attached to a bovine serum albumin protein and mixed with unlabelled antigenchloramphenicol, which was then added to the antibody-chloramphenicol. for U and Th respectively in water samples.

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Distance-of-Flight Mass Spectrometry: What, Why, and How?

Cited by 3 publications

References 69 publications

Recent Advances in Instrumental Approaches to Time‐of‐flight Mass Spectrometry

Recent Advances in Instrumental Approaches to Time‐of‐flight Mass Spectrometry

Improved detection sensitivity of elements in solids via laser postionization in laser desorption time‐of‐flight mass spectrometry

Atomic spectrometry update: review of advances in atomic spectrometry and related techniques

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