Distal digital keratoacanthoma: a report of 12 cases and a review of the literature

Baran, Robert; Goettmann, Sophie

doi:10.1046/j.1365-2133.1998.02421.x

Cited by 67 publications

(53 citation statements)

References 13 publications

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“…Therefore, in our patient, the differential diagnosis with a SCC was crucial, even though SCC occurs mainly in men in their sixties and is usually painless [6,7,8]. Distal digit keratoacanthoma can also present with similar clinical findings but is usually very painful and has a characteristic rapid growth, causing a crescent-shaped osteolysis [9,10]. …”

Section: Discussionmentioning

confidence: 99%

Subungual Solitary Angiokeratoma Simulating a Squamous Cell Carcinoma

Cunha

André

Saß

et al. 2017

Skin Appendage Disord

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Subungual angiokeratoma is extremely rare. Only 1 case is reported in the literature, presenting as a longitudinal pigmented band on a toenail. We report a case of a subungual angiokeratoma on a fingernail of a 43-year-old woman, clinically mimicking a squamous cell carcinoma. Medical imaging revealed a soft tissue tumor and erosion of the distal phalanx. Although extremely rare, solitary angiokeratomas may arise in the nail apparatus and should be added to the differential diagnosis of subungual warty tumors.

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Section: Discussionmentioning

confidence: 99%

Subungual Solitary Angiokeratoma Simulating a Squamous Cell Carcinoma

Cunha

André

Saß

et al. 2017

Skin Appendage Disord

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“…To our knowledge the occurrence of an SKA in an HNPCC gene carrier is original and led us to consider an MTS diagnosis. Despite exceptional cases of spontaneous resolutions [9], this rare painful and destructive variant of KA is regarded by some authors as a low-grade carcinoma, capable of local invasion and extension to the bone [10, 11]. SKA effectively differs from typical KA in regard to its occurrence on non-hair-bearing skin, a usual lack of typical histological collarette, and a tendency to deep invasion [12].…”

Section: Discussionmentioning

confidence: 99%

“…It usually clinically presents as a subungual distal horny cap (often preceded by onycholysis) and is associated with a punched-out area of bone destruction in the terminal phalanx that can be identified by X-ray imaging as a well-circumscribed radiological defect without sclerosis or periosteal reaction [11]. When possible, conservative local excision and curettage followed by careful monitoring is the first-line treatment of choice [11]. In our case this therapeutic option allows for a complete healing with a 1-year clinical and X-ray follow-up.…”

Section: Discussionmentioning

confidence: 99%

Solitary Subungual Keratoacanthoma Arising in an MSH2 Germline Mutation Carrier: Confirmation of a Relationship by Immunohistochemical Analysis

Stoebner

Fabre²,

Delfour³

et al. 2009

Dermatology

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Background: Muir-Torre syndrome (MTS) is an autosomal dominant disorder characterized by the concurrent or sequential development of at least 1 sebaceous gland tumor or keratoacanthoma and 1 or more internal malignancies. It is actually considered as a variant of hereditary nonpolyposis colorectal cancer (HNPCC) as both MTS and HNPCC are more often associated with germline mutations in the DNA mismatch repair (MMR) gene. Objective andMethods: We report the case of MTS diagnosed after the occurrence of a solitary subungual keratoacanthoma (SKA) in a man with a well-known family history of HNPCC and who is carrying a constitutional 1–7 deletion in the MSH2 MMR gene. Results: The link between the germline mutation and the skin tumor was reinforced by immunohistochemical staining. MSH2 immunoreactivity was decreased in SKA tumoral cells when compared to normal adjacent epidermis and to 5 cases of sporadic KA used as controls. Conclusion: This observation indicates that a solitary SKA may be the first clinical manifestation of MTS and brings up the relevance for regular dermatological screening for MTS-associated skin lesions among gene carriers (and symptomatic individuals) for HNPCC syndrome.

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“…Rarely, KAs originating from the nailbed in humans can cause local destruction in the form of pressure lysis of the underlying phalanx. They differ from KAs in other sites in that they do not usually regress (Baran & Goettmann, 1998;Lovett et al, 1995;Schwartz, 1979;Sullivan & Colditz, 1979). KAs are also infrequently reported in veterinary literature as arising from the nailbed epithelium of single digits in dogs and cats (Goldschmidt & Hendrick, 2002;Gross et al, 2006).…”

mentioning

confidence: 99%

“…KAs are also infrequently reported in veterinary literature as arising from the nailbed epithelium of single digits in dogs and cats (Goldschmidt & Hendrick, 2002;Gross et al, 2006). Histologically, subungual KAs tend to have more dyskeratotic cells and less associated inflammation and fibrosis in comparison with those in other locations (Baran & Goettmann, 1998).…”

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confidence: 99%