Dissolving Microneedle Arrays with Optimized Needle Geometry for Transcutaneous Immunization

Li, Yingying; Xia, Hu; Dong, Zhiyong; Chen, Yuanzheng; Zhao, Weiman; Wang, Yushuai; Zhang, Lu; Chen, Minglong; Wu, Chuanbin; Wang, Qingqing

doi:10.1016/j.ejps.2020.105361

Cited by 51 publications

(29 citation statements)

References 36 publications

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“…In addition to drug delivery, MNs have been used for transcutaneous immunization and the effects of MN geometries on the feasibility of transcutaneous immunization have been investigated [ 142 ]. In one study, the geometry of dissolving MNs was investigated for the delivery of ovalbumin [ 143 ]. The results of this study indicated that the needle morphology of dissolving MNs influenced their mechanical properties, dissolution and insertion capacity, which in turn affected the immune response.…”

Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

“…The results of this study indicated that the needle morphology of dissolving MNs influenced their mechanical properties, dissolution and insertion capacity, which in turn affected the immune response. In this study, cone-shaped MNs were found to be the optimal shape for ovalbumin delivery and transcutaneous immunization [ 143 ]. This was due to the relationship between apex angles and length-diameter ratios—cone-cylinder MNs used in this study had an increasing apex angle with a decreasing diameter, which increased the risk of needle fracture when force was applied.…”

Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.

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Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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“…Superior capacity to insert into the skin was observed for the sharper edges of the triangular and square MNs compared to the hexagonal MNs. In a recent study, cone-shaped MNs were discovered to possess the ideal geometry for the delivery of ovalbumin and transcutaneous immunisation, with both greater needle insertion and a fast dismantling time for a more potent immune response obtained [64]. A further improvement has been proposed recently to reduce the risk of insufficient drug delivery, wherein an array of hemispherical convexities was positioned in the lower half of the cone-shaped dissolving MNs to increase drug flux [65].…”

Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

Microneedles in Drug Delivery: Progress and Challenges

Avcil¹,

Çelik²

2021

Micromachines

104

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In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals for several applications, including vaccines, drugs, and biomolecules for skin-related problems. The advantages of microneedle patch technology have been extensively evaluated in the latest literature; hence, the academic publications in this area are rising exponentially. Like all new technologies, the microneedle patch application has great potential but is not without limitations. In this review, we will discuss the possible limitations by highlighting the areas where a great deal of improvements are required. Emphasising these concerns early on should help scientists and technologists to address the matters in a timely fashion and to use their resources wisely.

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“…Previous studies have shown that the geometry of microneedles is significantly related to the skin penetration function, which is a critical factor for successful transdermal drug delivery [ 36 , 37 ]. The sharpness of the HMP-DMN tips and various configurations of the PLGA mixture and HA in the HMP-DMN patches could be controlled by optimizing the centrifugation and dispensing times, respectively, as shown in Figure 2 and Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)

Lee

Kim

et al. 2021

Pharmaceutics

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Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the use of potentially harmful organic solvents. The drug-loaded PLGA mixture, which consisted of a middle layer of the DMN, was optimized and successfully implanted into ex vivo porcine skin. Implanted HMP-DMNs separated from the patch within 10 min, enhancing user compliance, and the encapsulated molecules were released for nearly 4 weeks thereafter. In conclusion, the geometry of HMP-DMNs was successfully optimized for safe and effective transdermal sustained drug delivery without the use of organic solvents. This study provides a strategy for the innovative utilization of PLGA as a material for transdermal drug delivery systems.

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Dissolving Microneedle Arrays with Optimized Needle Geometry for Transcutaneous Immunization

Cited by 51 publications

References 36 publications

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Microneedles in Drug Delivery: Progress and Challenges

Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)

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