Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model

Bhatnagar, Shubhmita; Bankar, Neha Gajanan; Kulkarni, M V; Venuganti, Venkata Vamsi Krishna

doi:10.1016/j.ijpharm.2018.12.022

Cited by 100 publications

(53 citation statements)

References 38 publications

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“…The in vivo study revealed that dissolving MN system promoted the insulin absorption to reduce the blood glucose levels to 29% of initial level at 5 hours. Bhatnagar et al 20 fabricated the dissolvable MNs made of the mixture of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) for the codelivery of doxorubicin and docetaxel. It was concluded that the pyramidal-shaped MNs fully dissolved within 1 hour after inserted into the excised skin, reduced the tumor volume and tumor weight in 4T1 tumor-bearing athymic nude mice, and indicated greater survival compared with intratumoral injection.…”

Section: Classified By Drug Delivery Methodsmentioning

confidence: 99%

“…Since the first concept of MN was proposed as a drug delivery device in a US patent in 1971 by Gerstel and Place, 16 the MNs have been developed for delivery of drugs over several decades. Now, MN has been explored into various structures (out-of-plane MNs and in-plane MNs), materials (silicon, ceramic, glass, metal, and polymer), geometries (octagonal, 15 cylindrical, 17 rectangular, 18 pyramidal, 11,19–21 conical, 22,23,24 and quadrangular 25 ), and morphologies, that is, solid MN (first reported in 1971 by Gerstel and Place 16 ), hollow MN (first reported in 1971 by Gerstel and Place 16 ), dissolving MN (first reported in 2005 by Miyano et al 26 ), and coated MN (first reported in a patent in 1975 by Pistor 27 ). Meanwhile, a variety of manufacturing techniques (such as etching, micromolding techniques, and lithography) for any MNs mentioned above, comprehensively considering the factors, including materials, structures, morphologies, geometry, and size, have also been reported in numbers of literatures.…”

Section: Introductionmentioning

confidence: 99%

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Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Sun

Zhuang

et al. 2019

Dose-Response

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Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

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Section: Classified By Drug Delivery Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Sun

Zhuang

et al. 2019

Dose-Response

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“…In contrast, when DOX and DTX were delivered by MNs, 100% of the animals survived following the administration of four doses until 16 days. The significantly lower magnitude of systemic toxicity after MNs-based transdermal delivery may be attributed to the slow release of DOX [133]. Carvalho et al [137] evaluated the anticancer efficacy of colloidal-polysaccharide-drug nanocomplexes, made of carboxymethylcellulose (CMC)-DOX crosslinked with citric acid in a hydrogel-based formulation, using melanoma cell line (A375).…”

Section: Doxorubicin Hydrochloride (Dox)mentioning

confidence: 99%

“…Due to the high hydrophilicity of DOX, skin permeation is negligible. Therefore, MN-based transdermal systems of doxorubicin are gaining interest [ 133 , 134 , 135 ]. Unlike other physical techniques, such as ultrasound and thermal ablation, which are used to enhance permeation, MN does not require sophisticated instruments [ 32 , 136 ].…”

Section: Transdermal Permeation Study Using Selected Chemotherapeutic Agentsmentioning

confidence: 99%

Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities

et al. 2021

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Chemotherapeutic drugs are primarily administered to cancer patients via oral or parenteral routes. The use of transdermal drug delivery could potentially be a better alternative to decrease the dose frequency and severity of adverse or toxic effects associated with oral or parenteral administration of chemotherapeutic drugs. The transdermal delivery of drugs has shown to be advantageous for the treatment of highly localized tumors in certain types of breast and skin cancers. In addition, the transdermal route can be used to deliver low-dose chemotherapeutics in a sustained manner. The transdermal route can also be utilized for vaccine design in cancer management, for example, vaccines against cervical cancer. However, the design of transdermal formulations may be challenging in terms of the conjugation chemistry of the molecules and the sustained and reproducible delivery of therapeutically efficacious doses. In this review, we discuss the nano-carrier systems, such as nanoparticles, liposomes, etc., used in recent literature to deliver chemotherapeutic agents. The advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs are summarized. Furthermore, we also discuss a possible in silico approach, Formulating for Efficacy™, to design transdermal formulations that would probably be economical, robust, and more efficacious.

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“…Composites of PVA and PVP provide good plasticity and dissolvability to MNs. 114 These polymers are a choice for preparation of MNs for ocular use due to their quick disintegration and compatibility with tear fluid. 115 Collagen and its derivatives, silk, gelatin and zein are few protein-based materials that have been used for MN fabrication.…”

Section: Established Materials For Mn Constructionmentioning

confidence: 99%

Microneedle-based drug delivery: materials of construction

et al. 2019

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Microneedle-based drug delivery has attracted researchers' attention over the last decade. The material of construction of microneedles has emerged as a critical factor influencing clinical usage, manufacture, drug loading and drug stability. Initially, microneedles were fabricated using glass, silicon and metals. The development of sophisticated machining tools and advances in the polymer science allowed for a major shift in materials of construction of microneedles towards polymeric systems. Delivery of difficult to formulate therapeutics, including proteins, peptides, vaccines and genetic material has been established using microneedles. There is a constant search for newer materials, which can easily form microneedles with sufficient strength to penetrate biological barriers, can be easily manufactured, and are compatible with drug molecules and biological systems. While several reviews have discussed microneedle-based cosmetic and drug delivery applications, there is a gap in understanding the effect of material of construction of microneedles on drug stability and potential for large-scale manufacture. This review is an attempt to present microneedles as a function of the material used for its construction. Since microneedle commercialization is now a realistic possibility, we believe that improved understanding of materials and their chemistry will allow for improved decision making, especially for industries looking towards bringing microneedle technology to manufacturing setups.

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Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model

Cited by 100 publications

References 38 publications

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities

Microneedle-based drug delivery: materials of construction

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