Dissolution of a Clot Studied by Cinephotomicrography

Robb, Herbert J.; Jacobson, Lyle F.; Jordan, Pamela

doi:10.1001/archsurg.1963.01310110156021

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…hyaliner Kugeln gingen davon aus, dab die auch von ihnen beobachteten, zentral gelegenen Zellen den Kondensationskern der Fibrinprfizipitate darstellten (Apitz 1934;Zinck 1940;Robb et al 1963;Hardaway et al 1965;Sandritter und Lasch 1967). hyaliner Kugeln gingen davon aus, dab die auch von ihnen beobachteten, zentral gelegenen Zellen den Kondensationskern der Fibrinprfizipitate darstellten (Apitz 1934;Zinck 1940;Robb et al 1963;Hardaway et al 1965;Sandritter und Lasch 1967).…”

Section: Diskussionunclassified

Formvarianten kugelf�rmiger hyaliner Mikrothromben

1986

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Globular hyaline microthrombi are characterized by their diameter (2-30 micron), globular form, and positive PAS and PTAH reaction. They are a morphologic indicator of disturbed microcirculation and hemostasis, such as that occurring in shock. In two of our cases, we observed large globular hyaline microthrombi, some with central webbed degradation progressing to the formation of closed or open hollow globules. The electron microscopic findings were similar to those observed by other investigators in typical shock bodies. On the basis of the morphologic findings, the authors conclude that degradation phenomena start at the center of globular hyaline microthrombi and can progress to the surface where accelerated fibrinolysis is possible. The cellular elements that other investigators have described as a possible condensation center for fibrin precipitate proved to be structurally intact cells that are apparently located in niches of open hollow globules or in the center of circular hyaline microthrombi. The diagnostic relevance, vitality, and temporal classification are discussed.

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Section: Diskussionunclassified

Formvarianten kugelf�rmiger hyaliner Mikrothromben

1986

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“…The coagulability of blood increases at first in low output states and later decreases, with depletion of clotting factors and the formation of platelet microthrombi which may obstruct peripheral vascular beds. This tends to occur particularly in irreversible circulatory failure (Robb 1963, Hardaway 1962. A low platelet count with deficiency of other clotting factors may be found in meningococcal septicxmia especially, and the use of platelet transfusion and fresh frozen plasma, with or without fresh blood, may be necessary.…”

Section: Renal Failurementioning

confidence: 99%