Dynamics of the Microcirculation During a Burn

Robb, Herbert J.

doi:10.1001/archsurg.1967.01330120030007

Cited by 28 publications

(6 citation statements)

References 6 publications

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Section: Discussionmentioning

confidence: 99%

“…Inflammatory mediators generated from the inflammatory cells through thermal action can impact adversely on burn wounds (12)(13)(14)(15). Hemodynamic alterations and additional infection may also lead to further progression of burn wound necrosis (14,16). Following burn trauma, the zone of stasis can be supported and progressive tissue necrosis thereby prevented by salvaging this zone using agents with potential beneficial effects on perfusion in the affected area (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

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The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model

2018

Turk J Med Sci

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Background/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis. Materials and methods: Adult female rats were randomly divided two groups: the LMWH group (n = 8) rats received subcutaneous LMWH injections, while the saline group (n = 8) rats were injected with the same volume of saline solution by the same route. The zone of stasis was evaluated macroscopically and histologically, and functional capillary density was evaluated. Results: Histological assessments revealed higher macrophage numbers and PML density, fibroblast proliferation, and angiogenesis in the LMWH group than in the saline group. Functional capillary density measurement in the stasis zones revealed no significant difference between the two groups in the first 4 days, although a significant difference in favor of the LMW group was observed in the last 3 days. Conclusion: The results of this experimental study show that LMWH is effective in saving the zone of stasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model

2018

Turk J Med Sci

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“…it was suggested by him that in septicemia platelet count decreases at very low level of stimulus which is insufficient to induce other inflammatory responses. [5]  Robb HJ7 in 1967 (6) in his study of Dynamics of microcirculation during burn suggested that thrombocytopenia occurs due to huge consumptions of platelets by formation of precipitates and micro thrombi in arterioles and venules. [6]  Scoring system for immediate post traumatic patient evaluation classification and outcome prediction has gained increased acceptance during the past three decades.…”

Section: Discussionmentioning

confidence: 99%

“…[5]  Robb HJ7 in 1967 (6) in his study of Dynamics of microcirculation during burn suggested that thrombocytopenia occurs due to huge consumptions of platelets by formation of precipitates and micro thrombi in arterioles and venules. [6]  Scoring system for immediate post traumatic patient evaluation classification and outcome prediction has gained increased acceptance during the past three decades. The importance of prognostic indices of burn patient not only as a predicting outcome of patient but also as a therapeutic and research purpose.…”

Section: Discussionmentioning

confidence: 99%

Platelet Count, Its Significance in Burn Injury Management

Kujur¹,

Lakra²

2015

jemds

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“…A second-degree burn has thrombi in the venules only, and a third-degree burn has thrombi in the venules and arterioles [55] . Cotran et al [56] have elegantly demonstrated by electron microscopy, in a rat model, that after a mild thermal injury and at the periphery of more severe burns, there is an increase in vascular permeability produced by gaps in the endothelium with no demonstration of endothelial damage [56] .…”

Section: Thrombosis and Thromboembolismmentioning

confidence: 98%

Antithrombin in the treatment of burn trauma

Kowal-Vern

Orkin

2016

WJCCM

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Antithrombin (AT) is a natural anticoagulant with antiinflammatory properties that has demonstrated value in sepsis, disseminated intravascular coagulation and in burn and inhalation injury. With high doses, AT may decrease blood loss during eschar excision, reducing blood transfusion requirements. There are no human randomized, placebo-controlled studies, which have tested the true benefit of this agent in these conditions. Two main forms of AT are either plasma-derived AT (phAT) and recombinant AT (rhAT). Major ovine studies in burn and smoke inhalation injury have utilized rhAT. There have been no studies which have either translated the basic rhAT research in burn trauma, or determined the tolerance and pharmacokinetics of rhAT concentrate infusions in burn patients. Advantages of rhAT infusions are no risk of blood borne diseases and lower cost. However, the majority of human burn patient studies have been conducted utilizing phAT. Recent Japanese clinical trials have started using phAT in abdominal sepsis successfully. This review examines the properties of both phAT and rhAT, and analyzes studies in which they have been utilized. We believe that it is time to embark on a randomized placebo-controlled multi-center trial to establish the role of AT in both civilian and military patients with burn trauma.

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Dynamics of the Microcirculation During a Burn

Cited by 28 publications

References 6 publications

The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model

The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model

Platelet Count, Its Significance in Burn Injury Management

Antithrombin in the treatment of burn trauma

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