Dissolution Apparatus for Gels

Weng, Ho-Lun; Parrott, Eugene L.

doi:10.1002/jps.2600720223

Cited by 9 publications

(5 citation statements)

References 1 publication

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“…For assessing in vitro drug release, 1 g ADP gel (ACX3) was placed on the glass slide of the modified USP-II dissolution apparatus ( Weng and Parrott, 1983 ). Subsequent replenishment of buffer after each sample withdrawal was carried out.…”

Section: Resultsmentioning

confidence: 99%

“…In pursuit of predicting the pharmacokinetic properties of ADP delivered through the developed formulation, the release profile was determined in citrate buffer medium using a modified type-II USP dissolution apparatus ( Weng and Parrott, 1983 ). Since, the intended route of application is intravaginal, citrate buffer was used which mimics the simulated vaginal fluid ( Boyd and Hilas, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…For assessing in vitro drug release, 1 g ADP gel (ACX3) was placed on the glass slide of the modified USP-II dissolution apparatus (Weng and Parrott, 1983). Subsequent replenishment Graphical representation of the in vitro dissolution study for the assessment of the release of adapalene from the mucoadhesive vaginal gel (n = 3).…”

Section: In Vitro Dissolution Studymentioning

confidence: 99%

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Development of mucoadhesive adapalene gel for biotherapeutic delivery to vaginal tissue

Afzaal

Shahiq-uz-Zaman²,

Saeed³

et al. 2022

Front. Pharmacol.

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Purpose: Alternate formulation strategies need to be devised for improving the absorption and bioavailability of drug molecules administered through the intravaginal route. Enhancing the coating of vaginal mucosa can aid the achievement of this goal. The aim of the current study is to develop a mucoadhesive formulation having adequate adhesiveness, spreading, and viscosity profiles that can ensure good tissue absorption of adapalene upon intravaginal application.Method: A combination of mucoadhesive agents has been employed, including Carbopol-934, HPMC K-15M, and xanthan gum, in varying ratios to formulate five different gels. Furthermore, a cost-effective UV-spectroscopic analytical method was developed to quantify the amount of adapalene in tested samples, both of in vitro and in vivo origin. The analytical method was validated for different parameters, including specificity, linearity, range, accuracy, precision, and ruggedness. The modified USP-II apparatus was used for dissolution studies, while in vivo pharmacokinetic validation was performed in a murine model.Result: Of all the tested formulations, on the basis of the rheo-mechanical attributes, ACX3 performed better than the rest, including the commercially available intravaginal reference product. ACX3 had an average adhesion time of 12 min and a spread diameter of 37 mm. It showed 35 mm as average distance travelled by the diluted sample for leakage assessment. The analytical method developed for the adapalene muco-adhesive gel was within the range for all the validation parameters. For further evaluating the performance of the formulation, dissolution studies were conducted in simulated vaginal conditions which showed 94.83% of drug release within 5 minutes, while on completion of 30 min, it was measured to be 92.90%. Moreover, approximately 67% of the administered drug was recovered after 5 min of administration as evaluated through tissue recovery procedures in mice.Conclusion: The study aided in development of a formulation which can enhance the muco-adhesion of the drug molecule, resulting in an improved pharmacokinetic profile. Moreover, it established an efficient assay method which can be employed for in vitro and in vivo quantification of adapalene in simulated and physiological fluids.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…For assessing in vitro drug release, 1 g ADP gel (ACX3) was placed on the glass slide of the modified USP-II dissolution apparatus (Weng and Parrott, 1983). Subsequent replenishment Graphical representation of the in vitro dissolution study for the assessment of the release of adapalene from the mucoadhesive vaginal gel (n = 3).…”

Section: In Vitro Dissolution Studymentioning

confidence: 99%

See 1 more Smart Citation

Development of mucoadhesive adapalene gel for biotherapeutic delivery to vaginal tissue

Afzaal

Shahiq-uz-Zaman²,

Saeed³

et al. 2022

Front. Pharmacol.

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show abstract

“…A circular, 2.38-mm mesh stainless steel net of 8.0 cm diameter was placed at the bottom of the dissolution vessel. A stainless steel plate of 5.5 cm internal diameter and 5 mm height, with 5 g gel, was placed on the wire net (15). The paddle was set at the height of 2.5 cm from the gel surface.…”

Section: Modified Dissolution Apparatusmentioning

confidence: 99%

Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Ahmad¹,

Alam²,

Khan³

et al. 2008

Acta Pharmaceutica

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Development andin vitroevaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infectionsAn acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Monosodium citrate was used as an acid buffering agent to provide acidic pH (4.4). The drugs clotrimazole (antifungal) and metronidazole (antiprotozoal as well as antibacterial) were used in the formulation along withLactobacillusspores to treat mixed vaginal infections. Theex vivoretention study showed that the bioadhesive polymers hold the gel for 12-13 hours inside the vaginal tube. Results of thein vitroantimicrobial study indicated that the ABBV gel had better antimicrobial action than the commercial intravaginal drug delivery systems and retention was prolonged in anex vivoretention experiment.

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“…One of the simplest and most frequently used technique for the determination of the diffusion coefficient of a solute in a solid matrix is based on the transitory mass transfer analysis of solute release or uptake kinetics in a constant volume batch cell (Cussler, 1997;Crank and Park, 1968;Weng and Parrott, 1983). Providing that diffusion in the matrix is the controlling phenomenon (this point being obviously necessary to be checked, Favre et al, 2001), and that the batch cell is perfectly mixed, the intrinsic or effective diffusion coefficient D of the solute can be determined from the curve fit of the experimental data of uptake or release kinetics.…”

Section: Introduction: Fundamentals Of Diffusion Kineticsmentioning

confidence: 99%

Determination of diffusion coefficient from transitory uptake or release kinetics: Incidence of a recirculation loop

Castel¹,

Mazens²,

Favre³

et al. 2008

Chemical Engineering Science

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Dissolution Apparatus for Gels

Cited by 9 publications

References 1 publication

Development of mucoadhesive adapalene gel for biotherapeutic delivery to vaginal tissue

Development of mucoadhesive adapalene gel for biotherapeutic delivery to vaginal tissue

Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Determination of diffusion coefficient from transitory uptake or release kinetics: Incidence of a recirculation loop

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