Dissociation of tolerance to the analgesic and hypothermic effects of morphine by using thyrotropin releasing hormone

Bhargava, Hemendra N.

doi:10.1016/0024-3205(81)90460-4

Cited by 41 publications

(9 citation statements)

References 14 publications

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“…Perhaps the processes leading to the develop ment of tolerance to the analgesic and hypo thermic effects of morphine involve different mechanisms. Previously, studies from this laboratory have provided evidence for the dis sociation of tolerance to the analgesic and hypothermic effect of morphine in mice by using thyrotropin-releasing hormone [23], Inhibition of tolerance to the analgesic ac tivity of morphine in the rat by MK-801 was however associated with severe toxicity. In the absence of morphine, MK-801, in the doses used, did not display any overt toxic symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Dizocilpine(MK-801) Blocks Tolerance to the Analgesic but Not to the Hyperthermic Effect of Morphine in the Rat

Bhargava

Matwyshyn

1993

Pharmacology

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The effect of dizocilpine (MK-801), an N-methyl-D-aspartate receptor antagonist, on the development of tolerance to the analgesic and hyperthermic effects of morphine was determined in the rat. Tolerance to morphine in male Sprague-Dawley rats was induced by implanting subcutaneously 6 morphine pellets during a 7-day period. Two schedules of intraperitoneal injections of MK-801 were used. In one, the drug was injected once a day, and in the other it was injected twice a day. The doses of MK-801 were 0.03, 0.1 and 0.3 mg/ kg. In the treatment once a day, MK-801 blocked the development of tolerance to the analgesic effect of morphine, but there was no dose-dependent effect. In the treatment twice a day, MK-801 produced a dose-dependent inhibition of tolerance to the analgesic effect of morphine. Higher doses of MK-801 produced high mortality. MK-801 given once a day or twice a day failed to affect the tolerance to the hyperthermic effect of morphine. In both schedules of MK-801 treatment, the highest dose of MK-801 resulted in high mortality. It is concluded that MK-801 is selective in blocking the tolerance to the analgesic effect of morphine in the rat.

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Section: Discussionmentioning

confidence: 99%

“…The analgesic effect was measured by using a tailflick apparatus as described before [20][21][22][23]. The tailflick latencies to thermal stimulation were determined before and at various times up to 300 min after an injection of morphine (8 mg/kg, i.p.).…”

Section: Quantification O F the Analgesic And Hyperthermic Responses mentioning

confidence: 99%

Dizocilpine(MK-801) Blocks Tolerance to the Analgesic but Not to the Hyperthermic Effect of Morphine in the Rat

Bhargava

Matwyshyn

1993

Pharmacology

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“…The results also indicate that NMMA selec tively blocks the tolerance to the analgesic action of U-50,488H and perhaps the pro cesses leading to the development of tolerance to the analgesic and hypothermic actions of kopiate agonist may involve different mecha nisms. Previous studies from this laboratory have provided evidence for the dissociation of tolerance to the analgesic and hpyothermic actions of morphine in the mouse using thyro tropin-releasing hormone [28]. Similarly, tol erance to the analgesic action of morphine can be blocked by MK-801, an inhibitor of NMDA receptor, but the tolerance to the hypothermic action of morphine cannot be blocked by MK-801 [ 10], indicating that the two processes may involve distinct mechanisms.…”

Section: Discussionmentioning

confidence: 98%

Nitric Oxide Synthase Inhibition Blocks Tolerance to the Analgesic Action of k-Opiate Receptor Agonist in the Rat

Bhargava

1994

Pharmacology

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The effect of N^G-monomethyl-L-arginine (NMMA), an inhibitor of nitric oxide synthase, on the development of tolerance to the analgesic and hypothermic actions of U-50,488H, a highly selective ĸ-opiate agonist, was determined in the rat. Male Sprague-Dawley rats were rendered tolerant to the pharmacological actions of U-50,488H by twice daily intraperitoneal injections of the drug (25 mg/kg) for 4 days. To determine the effect of NMMA on tolerance to U-50,488H, NMMA was administered 10 min prior to each injection of U-50,488H. Multiple injections of U-50,488H resulted in the development of tolerance to its analgesic and hypothermic actions. NMMA (2, 4 and 8 mg/kg) inhibited the development of tolerance to the analgesic but not to the hypothermic action of U-50,488H. Multiple injections of U-50,488H resulted in a slower gain in body weight which was not modified by treatment with NMMA. The results indicate that inhibition of nitric oxide synthase can selectively block the tolerance to its analgesic action in the rat.

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“…Such a potentiation has been described by Plotnikoff & Kastin (1976) (Horita et al, 1976;Cox et al, 1976;Holaday et al, 1978;Bhargava et al, 1982), respiratory depression (Horita et al, 1976), locomotor depression or activation (Bhargava et al, 1982) and catalepsy (Holaday et al, 1978) induced by opiates. It also inhibits the development of tolerance to the analgesic effect of opiates (Bhargava, 1981) and inhibits the development of physical dependence on opiates (Bhargava, 1980). Previous studies have shown that naloxone at a non-hyperalgesic dose (1 mg kg' i.p.)…”

Section: Discussionmentioning

confidence: 99%

Potentiation by TRH of the effect of imipramine on the forced‐swimming test

Reny-Palasse

Rips

1985

British J Pharmacology

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Dissociation of tolerance to the analgesic and hypothermic effects of morphine by using thyrotropin releasing hormone

Cited by 41 publications

References 14 publications

Dizocilpine(MK-801) Blocks Tolerance to the Analgesic but Not to the Hyperthermic Effect of Morphine in the Rat

Dizocilpine(MK-801) Blocks Tolerance to the Analgesic but Not to the Hyperthermic Effect of Morphine in the Rat

Nitric Oxide Synthase Inhibition Blocks Tolerance to the Analgesic Action of k-Opiate Receptor Agonist in the Rat

Potentiation by TRH of the effect of imipramine on the forced‐swimming test

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