Dissociation of Delayed-Hypersensitivity and Antibody-Synthesising Capacities in Man

Fulginiti, VincentA.; Hathaway, W. E.; Pearlman, DavidS.; Blackburn, WillR.; Reiquam, C. W.; Githens, John H.; Claman, H N; Kempe, C. Henry

doi:10.1016/s0140-6736(66)91742-9

Cited by 78 publications

(10 citation statements)

References 6 publications

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“…The situation is likely to be more complex in other conditions of thymic failure whether or not they are associated with agamma globulinemia. Lymphocytes may be present in the thymus in either situation (16,17) and there is no evidence of a general stem cell deficiency as in reticular dysgenesia. Although the thymic anlage is formed, it is possible that it is functionally defective and fails to influence the differentiation of inflowing stem cells in a lymphoid direction.…”

Section: Chick Thymicmentioning

confidence: 99%

Tissue Interaction in the Development of Thymus Lymphocytes

Owen

Ritter

1969

The Journal of Experimental Medicine

266

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Thymic rudiments from chick and mouse embryos have been cultured in diffusion chambers on the chick chorioallantois. In this situation their supply of blood-borne stem cells is cut off. Although rudiments from older embryos become fully lymphoid under these circumstances, primordia from early embryos fail to develop any lymphoid cells. Early chick rudiments will however develop completely if they are grafted directly to the chorioallantois where they receive a vascular supply. It is concluded that stem cells first enter the chick thymic anlage at between 6 and 7 days' incubation and the mouse thymic rudiment between 10 and 11 days' gestation. During the following few days of development there is a rapid inflow of stem cells to the rudiments. Since it is likely that stem cells, once they have entered the thymic primordium, are capable of only limited proliferation, it must be concluded that an inflow of stem cells continues once full lymphopoiesis has begun, although perhaps at a reduced rate. Finally, the importance of the interaction between stem cell and organ rudiment to normal thymic development is discussed in relation to the pathogenesis of thymic anomalies.

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Section: Chick Thymicmentioning

confidence: 99%

Tissue Interaction in the Development of Thymus Lymphocytes

Owen

Ritter

1969

The Journal of Experimental Medicine

266

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“…It is likely that the lack of lymphocyte immune response to HBsAg in such patients permits persistence of antigenaemia and continued progressive liver cell damage. An analogous situation is seen in patients with generalized necrotic vaccinia after smallpox immunization, in whom there may be a failure to develop delayed hypersensitivity to the virus, dissociated from antibody synthesizing capacity and cellular response to other agents (Fulginiti, et al, 1966).…”

Section: Discussionmentioning

confidence: 87%

Lymphocyte response to hepatitis B surface antigen. Findings in hepatitis and Indian childhood cirrhosis.

Chandra¹

1975

Archives of Disease in Childhood

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“…Other infants with apparent isolated T cell deficiency have been observed in whom thymic dysplasia rather than thymic aplasia exists (Nezelof et al 1964, Fulginiti et al 1966. The thymus in these patients has the same appearance as that seen in many of the patients with congenital CID; it is small, consists almost entirely of epithelial cells, and has no Hassall's corpuscles.…”

Section: Congenital Thymic Dysplasiamentioning

confidence: 97%