Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage

A behavioural neuroscience perspective on the aetiology and treatment of anxiety disorders

“…A third issue involves the dissociation between mechanisms mediating the behavioural expression of fear from those that mediate the process of reconsolidation (e.g., Balderas, RodriguezOrtiz, & Bermudez-Rattoni, 2013;Ben Mamou, Gamache, & Nader, 2006;Caffaro, Suarez, Blake, & Delorenzi, 2012;Coccoz, Maldonado, & Delorenzi, 2011;Rodriguez-Ortiz, Balderas, GarciaDelatorre, & Bermudez-Rattoni, 2012;Sevenster et al, 2012aSevenster et al, , 2013. We observed that mere retrieval of the fear memory is not sufficient to induce its labilization and subsequent reconsolidation (Sevenster et al, 2012a, in press).…”

Fear reactivation prior to exposure therapy: Does it facilitate the effects of VR exposure in a randomized clinical sample?

“…Consequently, long-term effects (in the 6 months follow-up test) could not be unequivocally attributed to VR exposure (e.g., the reactivation extinction procedure). Further prior research has shown that memory reconsolidation differs from retrieval, as it involves destabilization and restabilization processes (Balderas et al, 2013;Ben Mamou, Gamache, & Nader, 2006;Caffaro, Suarez, Blake, & Delorenzi, 2012;Coccoz, Maldonado, & Delorenzi, 2011;Milton et al, 2013;Rodriguez-Ortiz, Balderas, Garcia-DeLaTorre, & Bermudez-Rattoni, 2012;Sevenster, Beckers, & Kindt, 2012, Sevenster et al, 2013. The different processes involved in the expression, destabilization, and restabilization of conditioned fear memories seem to be mediated by different receptors in the basolateral amygdala (Barreiro, Suarez, Lynch, Molina, & Delorenzi, 2013;Milton et al, 2013).…”

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker

“…There is growing evidence that the mechanisms mediating the behavioral expression of fear are clearly dissociated from the mechanisms mediating the process of reconsolidation 31,32,[56][57][58][59][60] . For instance, recent animal studies uncovered differential and dissociable receptors in the basolateral amygdala mediating the expression, destabilization and restabilization of previously conditioned fear memories 61,62 .…”