Dissociation between improvement in angina pectoris and myocardial perfusion after transmyocardial revascularization with an excimer laser

Improved quality of life after XeCl excimer transmyocardial laser revascularization: Results of a randomized trial

“…For one of these therapies, transmyocardial laser revascularization (TMLR), significant improvements in QOL have been reported in randomized studies using CO 2 or Ho:YAG lasers [1][2][3][4][5]. For the third clinically used laser, the XeCl excimer laser, uncontrolled studies have also reported promising clinical improvements [6][7][8][9]. In these studies laser parameters were used that were similar to ours (see below) or a shorter pulse (20-40 nanoseconds) with a lower pulse energy (9-15 mJ/pulse) was used at a higher repetition frequency (up to 240 Hz).…”

Cardiac denervation after clinical transmyocardial laser revascularization: short-term and long-term iodine 123–labeled meta-iodobenzylguanide scintigraphic evidence

“…1,2,4,5 Furthermore, nonrandomized xenon chloride (XeCl) excimer TMLR achieves similar anginal relief. 7,8 However, the anginarelieving mechanism is still poorly understood and probably multifactorial, reducing acceptance of TMLR. The original idea that direct perfusion from the left ventricle through the laser channels improves myocardial perfusion 9 currently has little support.…”