Dissociation between albuminuria and insulinaemia in hypertensive and atherosclerotic men

Abstract

To better understand the links between circulating insulin and albuminuria in essential hypertension, the plasma insulin response to a 75 gram glucose load and albuminuria were evaluated in 53 glucose-tolerant essential hypertensives and 12 controls. To allow any direct pressure-independent albuminuric effect of insulin to emerge more clearly, those same parameters were also evaluated in 20 glucose-tolerant normotensive patients with stable atherosclerotic peripheral vascular disease, a condition in which hyperinsulinaemia could be anticipated on the basis of previous reports. In response to glucose ingestion, hyperinsulinaemia was evident in both hypertensive and normotensive atherosclerotic patients, while, on average, urine albumin was elevated only in the former. When plasma insulin, systolic and diastolic blood pressure (BP) (by 24-h ambulatory BP monitoring), plasma glucose, triglycerides and

Abdominal obesity, systolic blood pressure, and microalbuminuria in normotensive and euglycemic Korean men

“…Similarly, several studies have suggested a differential effect according to body morphology. [15][16][17][18][19][20] The prevalence of MA among the study subjects was lower than that reported for a study of the general population. [5][6][7] This is expected following the selection criteria for the study.…”

“…On the other hand, contradictory results derived from apparently healthy, glucose-tolerant subjects suggest that MA is not necessarily related to IR. [12][13][14][15] In the present study, apparently healthy subjects were carefully selected based on a fasting plasma glucose o100 mg/dl and having a normal blood pressure. The data supports a lack of relationship between MA and IR as assessed from the HOMA model.…”

“…[9][10][11] Studies of glucose-tolerant subjects suggested that IR is not always associated with MA. [12][13][14] Some studies suggested that abdominal obesity is independently associated with MA, [15][16][17][18][19][20] whereas others showed that abdominal obesity is not related to the albuminuria level. 12,13 The latter studies may have been biased by factors such as a small sample size and the former studies did not exclude subjects with high-normal blood pressure or hypertension.…”

Peripheral vascular disease is associated with abnormal arteriolar diameter relationships at bifurcations in the human retina

“…All subjects underwent a glucose tolerance test [18] and measurements of fasting plasma lipids [17] as described previously.…”