Abdominal obesity, systolic blood pressure, and microalbuminuria in normotensive and euglycemic Korean men

Abstract

Objectives: To evaluate the relationship between abdominal obesity and microalbuminuria (MA) in normotensive, euglycemic Korean men. Design: A cross-sectional study at a health screening center. Subjects: A total of 1321 healthy, normotensive Korean men, aged 20-78 years, with a fasting plasma glucose level o100 mg/dl. Measurements: Height, weight, and waist; systolic blood pressure (SBP); diastolic blood pressures (DBP); urinary albumin to creatinine ratio (ACR); fasting glucose, insulin, lipids, C-reactive protein (CRP), and white blood cell count. Waist circumference (WC) was used to indicate abdominal obesity and a single measurement of ACR was used to estimate MA. We also calculated body mass index (BMI) based on weight and height. Results: Mean BMI, WC, and SBP were significantly higher in subjects with MA than in those without (24.874.1 vs 23.872.7 kg/m 2 , 8679 vs 8378 cm, and 11575 vs 11277 mmHg, respectively). Multiple logistic regression analyses showed that only WC and SBP were independent predictors of MA. Conclusion: WC and SBP were positively associated with MA in normotensive and euglycemic Korean men.

Low-grade albuminuria and incidence of cardiovascular disease and all-cause mortality in nondiabetic and normotensive individuals

“…This theory is based on previous studies which have been conducted among populations with different proportions of hypertension, diabetes, and renal dysfunction, which are linked with a risk of CVD. Cross-sectional studies for individuals with neither hypertension nor diabetes have demonstrated that microalbuminuria was associated with waist circumference [31], SBP [31], serum CRP levels [32]. Our findings suggest that, in normotensive individuals with no diabetes, the association between albuminuria and a risk of CVD was unlikely to be through blood pressure and inflammation, as this association remained significant after adjustment for SBP and hsCRP levels.…”

Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men

“…However, there might be several explanations underlying the effects of NAFLD on CKD. There is increasing evidence that obesity (visceral adiposity) may damage the kidney in otherwise healthy subjects [21][22][23]. Nonalcoholic fatty liver disease as a phenotype of excessive adiposity beyond normal liporegulation might be associated with CKD.…”

Obesity indices and adipokines in non-diabetic obese patients with early stages of chronic kidney disease

“…Ferris et al also found an association between MA and BMI, but only in patients with BMI ≥35 kg/m 2 [29]. In contrast, Chang et al did not find any significant relationship between BMI and MA in healthy, normotensive, euglycemic Korean men and suggested that only WC and systolic blood pressure (SBP) were independent predictors of MA [30]. These observations were supported by results from the multinational, multicenter large population study conducted by Thoenes et al on over 20 000 hypertensive out-patients from 26 countries [31].…”