Low-grade albuminuria and incidence of cardiovascular disease and all-cause mortality in nondiabetic and normotensive individuals

Tanaka, Fumitaka; Komi, Ryosuke; Makita, Shinji; Onoda, Toshiyuki; Tanno, Kozo; Ohsawa, Masaki; Itai, Kazuyoshi; Sakata, Kiyomi; Omama, Shinichi; Yoshida, Yuki; Ogasawara, Kuniaki; Ishibashi, Yutaka; Kuribayashi, Toru; Okayama, Akira; Nakamura, Motoyuki

doi:10.1097/hjh.0000000000000809

Cited by 66 publications

(58 citation statements)

References 47 publications

(60 reference statements)

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“…Recently, many researchers have focused on the clinical effects of low-grade albuminuria, which is defined as high level within urinary albumin-to-creatinine ratio (UACR) < 30 mg/g (10)(11)(12)(13)(14)(15)(16). Previous studies have shown an association between a high UACR and various cardiometabolic risk factors (10)(11)(12)(13)(14)(15)(16). In addition, some factors, including various cardiometabolic risk factors, have been shown to predict a high UACR; additional studies investigating new markers of a high UACR are on-going.…”

Section: Introductionmentioning

confidence: 99%

Glycated hemoglobin A1c level is associated with high urinary albumin/creatinine ratio in non-diabetic adult population

et al. 2016

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Non-DM participants with relatively high HbA1c levels should be closely monitored for UACR, especially if participants do not have MetS. KEY MESSAGES HbA1c level was positively associated with the proportion of participants with a high UACR and logUACR in participants without DM. For participants without MetS, the proportion of participants with a high UACR was greater in the High group than in the other groups and logUACR was greatest in the High group compared to the other groups. For participants with MetS, there were significant associations between HbA1c and the proportion of participants with a high UACR as a categorical variable or logUACR as a continuous variable, but the statistical significance of this finding was weak. No differences were found for proportions of participants with high UACR and logUACR values in the Low, Middle, and High groups.

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Section: Introductionmentioning

confidence: 99%

Glycated hemoglobin A1c level is associated with high urinary albumin/creatinine ratio in non-diabetic adult population

et al. 2016

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“…Increasing evidence has shown that low-grade albuminuria, defined as UACR as 0 to 30 mg/g, an earlier stage with UACR below the microalbuminuria threshold, is also associated with an increased risk of incident cardiovascular disease and all-cause mortality101112. The Heart Outcomes Prevention Evaluation (HOPE) study found a continuous association between levels of UACR and cardiovascular events6.…”

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confidence: 99%

Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: a cross-sectional analysis from I-Lan Longitudinal Aging Study

Chang

Hsu²,

Chang

et al. 2016

Sci Rep

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Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old). Assessment of frailty was based on the ‘Fried frailty phenotype’ criteria, including weight loss, grip strength, exhaustion, slowness and low physical activity. The study population was stratified into quartiles according to UACR levels. Age, body mass index, hypertension, diabetes, systolic blood pressure, insulin resistance, fasting glucose and high-sensitivity C-reactive protein levels were increased with the increment of UACR (P for trend <0.05). The prevalence of prefrailty/frailty and its components increased across the UACR quartiles. A multivariate stepwise logistic regression analysis revealed that UACR was independently associated with the likelihood of prefrailty/frailty (odds ratio 1.13, 95% CI 1.01–1.27). In conclusion, low-grade albuminuria is associated with the increased prevalence of prefrailty/frailty.

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“…Current data interpret MAU as a reliable marker of renal dysfunction and as a manifestation of total microvascular lesion and general cardiovascular risk [11]. Research of 1-2 degree hypertension showed that MAU rate in these patients is 12-22%, but the combination with obesity increases it to 30-40% [12].…”

Section: Fundingmentioning

confidence: 99%

Interrelation of Adipokines with Functional State of Kidneys in Patients with Metabolic Syndrome

Shulkina¹,

Смирнова²,

Trushin³

2016

Biol Med (Aligarh)

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The aim of this study was to evaluate the effect of adipokines on the formation of kidney disease in patients with obesity and hypertension. The survey included 87 patients with hypertension (stage 1-2): with obesity (n 5 67), without obesity (n 5 20). In control group, there were 25 obese patients without hypertension and metabolic changes and 30 healthy persons (mean age 48.2 6 2.4 years). We investigated the relationship between leptin, resistin, and integral indices of renal damage (glomerular filtration rate [GFR], microalbuminuria [MAU], vascular endothelial growth factor [VEGF]). In obese patients without clinical signs of renal disease, a decrease in GFR was detected in 44.7% of respondents. Levels of leptin and resistin, markers of renal damage (MAU, VEGF), were significantly higher in the group of obesity. Correlation analysis showed the existence of a high degree of direct connection between the level of adipokines and HOMA index, triglycerides (TG), MAU, VEGF in the urine, and a negative correlation with GFR. There was a direct positive relationship between the level of MAU and VEGF in the urine with levels of blood pressure, uric acid, and a negative one with GFR. Levels of MAU and VEGF in urine can be considered as early markers of renal dysfunction in obese patients. The decrease in GFR in patients with obesity was associated with increased levels of leptin and resistin. So, in patients with MS and hypertension, reduction of GFR is linked with the increase in leptin and resistin that is accompanied with the increase of VEGF in urine and MAU. In non-obese patients with hypertension obesity and MS, the increase of VEGF in urine is detected ealier that increase of MAU and reduction of GFR. B io lo g y and M e d ic in e

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Low-grade albuminuria and incidence of cardiovascular disease and all-cause mortality in nondiabetic and normotensive individuals

Abstract: In apparently healthy individuals with optimal blood pressure and no diabetes, LGA independently predicts CVD incidence and all-cause death, particularly with the large contribution to the excessive incidence of CVD.

Cited by 66 publications

References 47 publications

Glycated hemoglobin A1c level is associated with high urinary albumin/creatinine ratio in non-diabetic adult population

Glycated hemoglobin A1c level is associated with high urinary albumin/creatinine ratio in non-diabetic adult population

Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: a cross-sectional analysis from I-Lan Longitudinal Aging Study

Interrelation of Adipokines with Functional State of Kidneys in Patients with Metabolic Syndrome

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