Dissociated Sensation in Amyloidosis

Microneurographic findings in diabetic polyneuropathy with special reference to sympathetic nerve activity

“…With progression of the disease, more and more individual sympathetic fibres will cease to conduct, and consequently multiunit activity will be reduced successively until it can no longer be recorded. This conclusion is in accordance with previous studies of C-fibre conduction in vitro in polyneuropathy [9,10].…”

Trigeminal neuropathy with nasal ulceration: report of two cases and one necropsy.

“…In his extensive studies on senile amyloidosis of the cardiovascular system, Schwartz (1969) Kernohan and Woltman's (1942) view, represented an ischaemic neuropathy due to obliteration of the vasa nervorum. Doubts on this interpretation were cast when Dyck and Lambert (1969) demonstrated a selective loss of unmyelinated axons and when Coimbra and Andrade (1971b) suggested that fibre degeneration preceded the deposition of amyloid. Similarly, Schwartz's view that amyloidosis was the cause of senile dementia was refuted by Wisniewski and Terry (1973).…”

Hereditary amyloidosis

“…Patients of Portuguese descent found in Brazil, Africa, and France present the same clinical form and progression as seen in the patients living in Portugal even though their food and living habits may be markedly different (18). A family of Greek descent living in the United States has also been observed to present similar clinical and pathologic characteristics (19) . Although women tend to hide the disease so as not to decrease their marriage chances, the sex ratio of affected patients appears to be approximately 1 : 1, and the pedigrees provide good evidence for an autosomal dominant mode of inheritance (20) (Fig 1A) .…”