Dissociable roles of the medial prefrontal cortex, the anterior cingulate cortex, and the hippocampus in behavioural flexibility revealed by serial reversal of three-choice discrimination in rats

Kosaki, Yutaka; Watanabe, Shigeru

doi:10.1016/j.bbr.2011.10.039

Cited by 36 publications

(39 citation statements)

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“…Birell and Brown, 2000;Davidson and Jarrard, 2004;Floresco et al, 2008b;Jarrard and Davidson, 1991;Jung et al, 1998;Kosaki and Watanabe, 2012;Mogensen et al, 2003aMogensen et al, , 2003bRagozzino et al, 1999b]. However, studies examining the role of these two structures within a single behavioural paradigm are less frequent [Floresco et al, 1997;Kosaki and Watanabe, 2012;Lee and Solivan, 2008;Mogensen et al, 2004aMogensen et al, , 2005Mogensen et al, , 2007. Posttraumatic functional recovery studies from our laboratory indicate that the hippocampus contributes to the neural substrate for the functional recovery after prefrontal lesions and vice versa in a number of different tasks [Mogensen et al, 2004a[Mogensen et al, , 2005[Mogensen et al, , 2007.…”

Section: Interaction Between the Prefrontal Cortex And The Hippocampumentioning

confidence: 89%

“…Reversal tasks have provided a useful testing paradigm and several studies report clear hippocampal involvement, i.e. impairment of reversal conditioning and contextual reversal learning after hippocampal lesions [Berger and Orr, 1983;Jarrard et al, 2012;Kosaki and Watanabe, 2012;Silveira and Kimble, 1968;Winocur and Olds, 1978].…”

Section: The Hippocampus In Flexible Behavioural Switchingmentioning

confidence: 99%

“…Numerous studies have investigated the contribution of either the PFC or the hippocampus to task acquisition [e.g. Birell and Brown, 2000;Davidson and Jarrard, 2004;Floresco et al, 2008b;Jarrard and Davidson, 1991;Jung et al, 1998;Kosaki and Watanabe, 2012;Mogensen et al, 2003aMogensen et al, , 2003bRagozzino et al, 1999b]. However, studies examining the role of these two structures within a single behavioural paradigm are less frequent [Floresco et al, 1997;Kosaki and Watanabe, 2012;Lee and Solivan, 2008;Mogensen et al, 2004aMogensen et al, , 2005Mogensen et al, , 2007.…”

Section: Interaction Between the Prefrontal Cortex And The Hippocampumentioning

confidence: 99%

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Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery: Reversal learning and set-shifting in rats

Malá

Andersen

Christensen

et al. 2015

Brain Research Bulletin

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Section: Interaction Between the Prefrontal Cortex And The Hippocampumentioning

confidence: 89%

Section: The Hippocampus In Flexible Behavioural Switchingmentioning

confidence: 99%

Section: Interaction Between the Prefrontal Cortex And The Hippocampumentioning

confidence: 99%

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Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery: Reversal learning and set-shifting in rats

Malá

Andersen

Christensen

et al. 2015

Brain Research Bulletin

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“…Furthermore, lesions of the medial prefrontal cortex and hippocampus increased perseverative errors. By contrast, lesions of the anterior cingulate cortex increased random errors (Kosaki and Watanabe 2012). Our model focused on the MS/VDB and its possible influence on many of these areas, such as the hippocampus and the cingulate, including the anterior cingulate, which is part of the mPFC.…”

Section: Role Of the Ms/vdb During Reversal Learningmentioning

confidence: 99%

Learning to ignore: A modeling study of a decremental cholinergic pathway and its influence on attention and learning

et al. 2014

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Learning to ignore irrelevant stimuli is essential to achieving efficient and fluid attention, and serves as the complement to increasing attention to relevant stimuli. The different cholinergic (ACh) subsystems within the basal forebrain regulate attention in distinct but complementary ways. ACh projections from the substantia innominata/nucleus basalis region (SI/ nBM) to the neocortex are necessary to increase attention to relevant stimuli and have been well studied. Lesser known are ACh projections from the medial septum/vertical limb of the diagonal band (MS/VDB) to the hippocampus and the cingulate that are necessary to reduce attention to irrelevant stimuli. We developed a neural simulation to provide insight into how ACh can decrement attention using this distinct pathway from the MS/VDB. We tested the model in behavioral paradigms that require decremental attention. The model exhibits behavioral effects such as associative learning, latent inhibition, and persisting behavior. Lesioning the MS/VDB disrupts latent inhibition, and drastically increases perseverative behavior. Taken together, the model demonstrates that the ACh decremental pathway is necessary for appropriate learning and attention under dynamic circumstances and suggests a canonical neural architecture for decrementing attention.In order to cope with uncertainty in the environment, organisms need to constantly regulate their attentional resources by increasing attention to salient or relevant cues, and also decreasing attention to irrelevant cues. The basal forebrain (BF) has specific and separate pathways for decrementing and incrementing attention. Whereas ACh projections from the medial septum/vertical limb of the diagonal band (MS/VDB) to the hippocampus and cingulate cortex are crucial to reduce attention to irrelevant stimuli (Baxter et al. 1997), ACh projections from the substantia innominata/nucleus basalis region (SI/nBM) to the neocortex are necessary to increase attention to relevant stimuli (Chiba et al. 1995). The importance of disregarding irrelevant information in the environment in support of fluid attention to relevant information is highlighted by learning difficulties in which this function is dysregulated, including various subtypes of attention deficit hyperactivity disorder, a form of mild cognitive impairment that precedes dementia, and schizophrenia (for review, see Lubow and Weiner 2010).The decremental pathway from MS/VDB is necessary for decreasing attention to nonrewarding stimuli. Baxter et al. (1997) and Chiba et al. (1995) performed an experiment designed to test latent inhibition, which is the slower learning of a previously exposed, uninformative stimulus. Lesions of the MS/VDB, but not SI/nBM, disrupted latent inhibition. That is, control rats showed diminished conditioning to a preexposed stimulus, as compared to a novel stimulus. However, conditioning to the novel and preexposed cues occurred at the same level in the MS/VDB lesioned rats. The incremental pathway from SI/nBM is necessary for increasing at...

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“…When tested in a fivechoice reaction time paradigm, hippocampus-lesioned rats persist in responding on the lever rather than collecting the reward, so that a dissipative behavior develops (Chudasama et al 2012). Similarly, a tendency to perseverate on a previously selected response has been observed following hippocampal lesions in the three-choice discrimination task (Kosaki and Watanabe 2012).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole

et al. 2015

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Rationale Compulsive symptoms develop in patients exposed to pramipexole (PPX), a dopaminergic agonist with high selectivity for the D3 receptor. Consistently, we demonstrated that PPX produces an exaggerated increase in contrafreeloading (CFL) for water, a repetitive and highly inflexible behavior that models core aspects of compulsive disorders. Objectives Given the role of the hippocampus in behavioral flexibility, motivational control, and visuospatial working memory, we investigated the role of hippocampus in the expression of PPX-induced CFL. To this aim, rats were subjected to CFL under chronic PPX, and then examined for the electrophysiological, structural, and molecular properties of their hippocampus. Methods We measured long-term potentiation (LTP) at CA1 Schaffer collaterals, dendritic spine density in CA1 pyramidal neurons, and then glutamate release and expression of pre and postsynaptic proteins in hippocampal synaptosomes. The effects of PPX on hippocampal-dependent working memory were assessed through the novel object recognition (NOR) test.Results We found that PPX-treated rats showing CFL exhibited a significant decrease in hippocampal LTP and failed to exhibit the expected increase in hippocampal spine density. Glutamate release and PSD-95 expression were decreased, while pSYN expression was increased in hippocampal synaptosomes of PPX-treated rats showing CFL. Despite a general impairment of hippocampal synaptic function, working memory was unaffected by PPX treatment. Conclusions Our findings demonstrate that chronic PPX affects synaptic function in the hippocampus, an area that is critically involved in the expression of flexible, goalcentered behaviors. We suggest that the hippocampus is a promising target in the pharmacotherapy of compulsive disorders.

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Dissociable roles of the medial prefrontal cortex, the anterior cingulate cortex, and the hippocampus in behavioural flexibility revealed by serial reversal of three-choice discrimination in rats

Cited by 36 publications

References 74 publications

Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery: Reversal learning and set-shifting in rats

Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery: Reversal learning and set-shifting in rats

Learning to ignore: A modeling study of a decremental cholinergic pathway and its influence on attention and learning

Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole

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