Dissociable Roles of the Anterior Temporal Regions in Successful Encoding of Memory for Person Identity Information

Tsukiura, Takashi; Mano, Yoko; Sekiguchi, Atsushi; Yomogida, Yukihito; Hoshi, Kaori; Kambara, Tomihito; Takeuchi, Hikaru; Sugiura, Motoaki; Kawashima, Ryuta

doi:10.1162/jocn.2009.21349

Cited by 45 publications

(36 citation statements)

References 44 publications

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“…Our finding of left hippocampus-left temporal pole FC during face perception in healthy subjects is consistent with the observation of intrinsic FC between anterior hippocampus and anterior temporal pole in humans and non-human primates (Kahn et al, 2008), and with increased FC between hippocampus and left temporal pole during successful retrieval of memory for face-name associations (Tsukiura et al, 2010). Interestingly, we observed that this FC is reduced in subjects with SAD, particularly during neutral (primary sample) and angry face (replication sample) processing (see Supplementary information for further discussion regarding differences between these samples).…”

Section: Discussionsupporting

confidence: 91%

Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment

Pantazatos

Talati

Schneier

et al. 2013

Neuropsychopharmacol

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Group functional magnetic resonance imaging (fMRI) studies suggest that anxiety disorders are associated with anomalous brain activation and functional connectivity (FC). However, brain-based features sensitive enough to discriminate individual subjects with a specific anxiety disorder and that track symptom severity longitudinally, desirable qualities for putative disorder-specific biomarkers, remain to be identified. Blood oxygen level-dependent (BOLD) fMRI during emotional face perceptual tasks and a new, large-scale and condition-dependent FC and machine learning approach were used to identify features (pair-wise correlations) that discriminated patients with social anxiety disorder (SAD, N ¼ 16) from controls (N ¼ 19). We assessed whether these features discriminated SAD from panic disorder (PD, N ¼ 16), and SAD from controls in an independent replication sample that performed a similar task at baseline (N: SAD ¼ 15, controls ¼ 17) and following 8-weeks paroxetine treatment (N: SAD ¼ 12, untreated controls ¼ 7). High SAD vs HCs discrimination (area under the ROC curve, AUC, arithmetic mean of sensitivity and specificity) was achieved with two FC features during unattended neutral face perception (AUC ¼ 0.88, Po0.05 corrected). These features also discriminated SAD vs PD (AUC ¼ 0.82, P ¼ 0.0001) and SAD vs HCs in the independent replication sample (FC during unattended angry face perception, AUC ¼ 0.71, P ¼ 0.01). The most informative FC was left hippocampus-left temporal pole, which was reduced in both SAD samples (replication sample P ¼ 0.027), and this FC increased following the treatment (post4pre, t (11) ¼ 2.9, P ¼ 0.007). In conclusion, SAD is associated with reduced FC between left temporal pole and left hippocampus during face perception, and results suggest promise for emerging FC-based biomarkers for SAD diagnosis and treatment effects.

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Section: Discussionsupporting

confidence: 91%

Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment

Pantazatos

Talati

Schneier

et al. 2013

Neuropsychopharmacol

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“…A recent report seems to suggest a differential role of the dorsal and ventral portions of the left ATL in the processing of person identity. Specifically, the dorsal portion of the left ATL would be involved in access to the name while the ventral portion would be involved in the processing of person-related semantics (Tsukiura et al, 2010). Further studies specifically addressing this issue and investigating the modulation of connections between left ATL, perceptual and language regions during famous face semantic and naming tasks, will help confirming this hypothesis.…”

Section: Discussionmentioning

confidence: 88%

The role of the left anterior temporal lobe in the semantic processing of famous faces

et al. 2010

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“…Next, we asked whether the ATL acts as a neural switchboard, performing in concert with other brain regions to enable the retrieval of different facets of person knowledge in a flexible and context-appropriate manner (study 2). We focus on the ATL because multiple lines of evidence from neuropsychology, electrophysiology, and neuroimaging have documented the critical role of the ATL in person identification (4, 5, 11-16), person-related learning (10,(17)(18)(19)(20)(21), semantic memory (6-8), and abstract social knowledge (1,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Individuals with ATL damage due to resection or stroke have multimodal person recognition deficits (34), lose access to stored knowledge about familiar people (35,36), and have difficulties learning information about new people (4,22,37,38).…”

mentioning

confidence: 99%

Dynamic neural architecture for social knowledge retrieval

Wang

Collins

Koski

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Social behavior is often shaped by the rich storehouse of biographical information that we hold for other people. In our daily life, we rapidly and flexibly retrieve a host of biographical details about individuals in our social network, which often guide our decisions as we navigate complex social interactions. Even abstract traits associated with an individual, such as their political affiliation, can cue a rich cascade of person-specific knowledge. Here, we asked whether the anterior temporal lobe (ATL) serves as a hub for a distributed neural circuit that represents person knowledge. Fifty participants across two studies learned biographical information about fictitious people in a 2-d training paradigm. On day 3, they retrieved this biographical information while undergoing an fMRI scan. A series of multivariate and connectivity analyses suggest that the ATL stores abstract person identity representations. Moreover, this region coordinates interactions with a distributed network to support the flexible retrieval of person attributes. Together, our results suggest that the ATL is a central hub for representing and retrieving person knowledge.person knowledge | anterior temporal lobe | person identity node | semantic memory | social neuroscience A s social creatures, it is essential that we develop a rich storehouse of knowledge about other members of our social network, such as who they are, how they look and sound, where they live, and what they do for a living. However, little is known about how and where such "person knowledge" is represented, stored, and retrieved in the brain. This inquiry is challenging because person knowledge is highly multimodal and multifaceted, being linked to both abstract features such as personality and social status as well as more concrete features such as eye color; in addition, familiar individuals are associated with detailed episodic and semantic memories (e.g., memories of shared experiences and biographic information) (1, 2). The neural circuit for person knowledge must therefore have the ability to combine multiple sources of information into an abstract representation accessible from multiplicative cues.An influential theory by Burton and Bruce (3) proposes that person recognition is achieved through a hierarchical process that begins with the activation of modality-specific recognition units that selectively respond to the presence of a known face, name, or voice. This information is then sent to an amodal person identity node (PIN) that integrates information from the modality-specific recognition units into a multimodal representation for that individual. Excitation of the PIN ultimately allows the retrieval of personspecific semantic information independently of stimulus modality (4, 5). A similar design is embedded in the "hub-and-spoke" theory of semantic knowledge, which proposes that different features of a concept (such as its color or taste) are distributed throughout the brain (the "spokes") and that a centralized "hub" integrates these features into a cohe...

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Dissociable Roles of the Anterior Temporal Regions in Successful Encoding of Memory for Person Identity Information

Cited by 45 publications

References 44 publications

Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment

Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment

The role of the left anterior temporal lobe in the semantic processing of famous faces

Dynamic neural architecture for social knowledge retrieval

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