The role of the left anterior temporal lobe in the semantic processing of famous faces

Brambati, Simona Maria; Benoit, Sophie; Monetta, Laura; Belleville, Sylvie; Joubert, Sven

doi:10.1016/j.neuroimage.2010.06.045

Cited by 50 publications

(40 citation statements)

References 43 publications

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“…The areas that underwent major atrophic changes in svPPA, ventral and lateral temporal lobes, are part of a network involved in semantic memory (Butler et al, 2009; Mummery et al, 1999; Williams et al, 2005), exception word reading (Brambati et al, 2009b; Wilson et al, 2012a), identification of visual attributes (D'Esposito et al, 1997; Vandenbulcke et al, 2006), famous faces (Brambati et al, 2010; Gesierich et al, 2012; Gorno-Tempini et al, 1998; Kanwisher et al, 1997), buildings and landscapes (Epstein and Kanwisher, 1998). The progressive volume contraction in these areas is clinically associated with worsened single word comprehension abilities.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study

Brambati

Amici

Racine

et al. 2015

NeuroImage: Clinical

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The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period.Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.

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Section: Discussionmentioning

confidence: 99%

Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study

Brambati

Amici

Racine

et al. 2015

NeuroImage: Clinical

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“…Cluster 4 included the least heterogeneous grouping and was primarily dominated by experiments involving face naming. Recollection of semantic knowledge of famous faces is known to recruit middle temporal cortex, especially the anterior middle temporal gyrus (Gorno Tempini et al, 1998; Brambati et al, 2010). Cluster 4 demonstrated correspondence to lexical knowledge and retrieval, relying on temporal pole, inferotemporal cortex, and middle temporal gyrus (Damasio et al, 1996; Price et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Neural architecture underlying classification of face perception paradigms

et al. 2015

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We present a novel strategy for deriving a classification system of functional neuroimaging paradigms that relies on hierarchical clustering of experiments archived in the BrainMap database. The goal of our proof-of-concept application was to examine the underlying neural architecture of the face perception literature from a meta-analytic perspective, as these studies include a wide range of tasks. Task-based results exhibiting similar activation patterns were grouped as similar, while tasks activating different brain networks were classified as functionally distinct. We identified four sub-classes of face tasks: (1) Visuospatial Attention and Visuomotor Coordination to Faces, (2) Perception and Recognition of Faces, (3) Social Processing and Episodic Recall of Faces, and (4) Face Naming and Lexical Retrieval. Interpretation of these sub-classes supports an extension of a well-known model of face perception to include a core system for visual analysis and extended systems for personal information, emotion, and salience processing. Overall, these results demonstrate that a large-scale data mining approach can inform the evolution of theoretical cognitive models by probing the range of behavioral manipulations across experimental tasks.

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“…While we can assume that regions implicated in semantic control system may be amodal, specific subregions within this network may be recruited differently, depending on the type of conceptual knowledge required to be processed, on the nature of the input or on the nature of the task demands (Brambati, Benoit, Monetta, Belleville, & Joubert, 2010).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

et al. 2015

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Semantic memory recruits an extensive neural network including the left inferior prefrontal cortex (IPC) and the left temporoparietal region, which are involved in semantic control processes, as well as the anterior temporal lobe region (ATL) which is considered to be involved in processing semantic information at a central level. However, little is known about the underlying neuronal integrity of the semantic network in normal aging. Young and older healthy adults carried out a semantic judgment task while their cortical activity was recorded using magnetoencephalography (MEG). Despite equivalent behavioral performance, young adults activated the left IPC to a greater extent than older adults, while the latter group recruited the temporoparietal region bilaterally and the left ATL to a greater extent than younger adults. Results indicate that significant neuronal changes occur in normal aging, mainly in regions underlying semantic control processes, despite an apparent stability in performance at the behavioral level.

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The role of the left anterior temporal lobe in the semantic processing of famous faces

Cited by 50 publications

References 43 publications

Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study

Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study

Neural architecture underlying classification of face perception paradigms

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

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