Dissemination of Panton-Valentine leukocidin–positive methicillin-resistant Staphylococcus aureus USA300 clone in multiple hospitals in Tokyo, Japan

Takadama, Shunsuke; Nakaminami, Hidemasa; Sato, Ayumu; Shoshi, Manami; Fujii, Takeshi; Noguchi, Norihisa

doi:10.1016/j.cmi.2018.02.012

Cited by 59 publications

(63 citation statements)

References 30 publications

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“…The prevalence of PVL‐positive CA‐MRSA strains was increasing during the study period. Three of them were the CC59‐V Taiwan clone, which is frequent among Asian PVL‐positive CA‐MRSA strains . The PVL‐positive CC59‐V strains found in this study were negative for et genes despite being derived from patients with impetigo.…”

Section: Discussionmentioning

confidence: 68%

“…Three of them were the CC59-V Taiwan clone, which is frequent among Asian PVLpositive CA-MRSA strains. 20,23 The PVL-positive CC59-V strains found in this study were negative for et genes despite being derived from patients with impetigo. CC59-V strains carry not only PVL genes but also seb.…”

Section: Discussionmentioning

confidence: 77%

“…Polymerase chain reaction assays for the detection of mecA, ET genes (eta, etb and etd), SE genes (sea, seb, sec, sed, see, seg, seh, sei and sej), TSST-1 gene (tst), PVL genes (lukS/F-PV), ACME genes (arcA and opp-3C), macrolide-resistance genes (ermA and ermC) and aminoglycoside-resistance gene (aacA-aphD) were carried out as described previously. 6,23 SCCmec typing was conducted as described elsewhere. 8 Isolates not identified as SCCmec types I-V were classified as non-typeable.…”

Section: Pcr Amplificationmentioning

confidence: 99%

“…Recently, PVL‐positive CA‐MRSA such as the USA300 clone emerged in both community and hospital settings in Japan . Hence, clonal types of CA‐MRSA strains are predicted to be changing.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20][21] Recently, PVL-positive CA-MRSA such as the USA300 clone emerged in both community and hospital settings in Japan. 15,20,22,23 Hence, clonal types of CA-MRSA strains are predicted to be changing. Nevertheless, long-term surveillance of CA-MRSA has not been conducted in Japan.…”

Section: Introductionmentioning

confidence: 99%

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Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Sasai

Nakaminami

Iwasaki

et al. 2019

The Journal of Dermatology

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Recently, the USA300 clone, which is a Panton–Valentine leukocidin (PVL)‐positive clonal complex 8‐staphylococcal cassette chromosome mec type IV (CC8‐IV) community‐acquired methicillin‐resistant Staphylococcus aureus (CA‐MRSA) strain, emerged in community and hospital settings in Japan. Hence, clonal types of CA‐MRSA strains are predicted to be changing. Nonetheless, long‐term surveillance of CA‐MRSA has not been conducted in Japan. Here, we investigated the transition and current status of CA‐MRSA strains isolated from outpatients with impetigo; the samples were collected between 2007 and 2016 in Kagawa, Japan. The detection rate (22.8%, 488/2139 strains) of MRSA slightly decreased in these 10 years. Molecular epidemiological analyses showed that the prevalence of the CC89‐II clone, which is a typical CA‐MRSA genotype of causative agents of impetigo, significantly decreased from 48.0% (48/100 strains) in 2007–2009 to 21.9% (16/73 strains) in 2013–2016. By contrast, a non‐USA300 CC8‐IV clone, which is a highly pathogenic CA‐MRSA/J clone, significantly increased in prevalence from 9.0% (9/100 strains) to 32.9% (24/73 strains). The prevalence of PVL‐positive CA‐MRSA strains increased annually from 2012 (0%) to 2015 (6.7%), whereas only one of these strains turned out to be the USA300 clone. Antibiotic susceptibility data revealed that the rates of resistance to gentamicin and clindamycin among CA‐MRSA strains decreased along with the decreased prevalence of the CC89‐II clone and increased prevalence of the CA‐MRSA/J clone. Our data strongly suggest that the clonal types and antibiotic susceptibility of CA‐MRSA isolated from patients with impetigo dramatically changed during the last 10 years in Japan.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 77%

Section: Pcr Amplificationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Sasai

Nakaminami

Iwasaki

et al. 2019

The Journal of Dermatology

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Severity and intractableness of skin infections caused by Panton–Valentine leukocidin‐positive methicillin‐resistant Staphylococcus aureus

Kawakami

Yokoyama

Ikeda

et al. 2023

J Cutaneous Imm & Allergy

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Cases of skin infections caused by Panton–Valentine leukocidin (PVL)‐positive methicillin‐resistant Staphylococcus aureus (MRSA), particularly USA300 clone, have been increasing in Japan. We report that clinical findings of 5 patients with PVL‐positive MRSA and compared to those of four patients with PVL‐negative MRSA. Severities of patients with PVL‐positive MRSA were significantly higher than those of patients with PVL‐negative MRSA. Average durations of antimicrobial therapy for patients with PVL‐positive MRSA were 3.4‐fold longer than those for patients with PVL‐negative MRSA. Our data suggest that PVL‐positive MRSA should be deal with a causative agent for intractable skin infections in Japan likewise other countries.

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Nanomaterial-based optical and electrochemical techniques for detection of methicillin-resistant Staphylococcus aureus: a review

Gill

Singh

Thapliyal³

et al. 2019

Microchim Acta

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Dissemination of Panton-Valentine leukocidin–positive methicillin-resistant Staphylococcus aureus USA300 clone in multiple hospitals in Tokyo, Japan

Abstract: This is the first report on dissemination of the USA300 clone and PVL-positive MRSA in multiple Japanese hospitals. Our data strongly suggest that the USA300 clone may become epidemic in Japanese hospitals.

Cited by 59 publications

References 30 publications

Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Clonal change of methicillin‐resistant Staphylococcus aureus isolated from patients with impetigo in Kagawa, Japan

Severity and intractableness of skin infections caused by Panton–Valentine leukocidin‐positive methicillin‐resistant Staphylococcus aureus

Nanomaterial-based optical and electrochemical techniques for detection of methicillin-resistant Staphylococcus aureus: a review

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